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  • Official Full Name
  • cartilage oligomeric matrix protein
  • Background
  • Cartilage oligomeric matrix protein is a protein that in humans is encoded by the COMP gene. The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfide bonds. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED)
  • Synonyms
  • COMP; cartilage oligomeric matrix protein; cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple) , EDM1, EPD1, PSACH; MED; THBS5; thrombospondin 5; TSP5; thrombospondin-5; pseudoachondroplasia (epiphyseal dysplasia 1
Cat.#:COMP-1687HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human COMP Protein, GST-tagged
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Cat.#:COMP-11451HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COMP, GST-tagged
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Cat.#:COMP-26251THTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human COMP, FLAG-tagged
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Cat.#:COMP-3658HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human COMP, His-tagged
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Cat.#:COMP-3659HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human COMP protein, FLAG-tagged
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Cat.#:COMP-5794HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COMP protein, His & T7-tagged
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Cat.#:COMP-674HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human COMP, His tagged
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Cat.#:COMP-675HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human COMP protein, His-tagged
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Cat.#:COMP-3770MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse COMP Protein
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Cat.#:Comp-5795MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Comp protein, His-tagged
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Cat.#:COMP-1528RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat COMP Protein
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Cat.#:Comp-5796RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Comp protein, His-tagged
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Cat.#:Comp-5797RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Comp protein, His-tagged
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Cat.#:COMP-0393BTag:His
Source (Host):E. coli or YeastSpecies:Bacillus subtilis
Product nameRecombinant Bacillus subtilis COMP protein, His-tagged
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Cat.#:COMP-3031HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human COMP cell lysate
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Involved Pathway

COMP involved in several pathways and played different roles in them. We selected most pathways COMP participated on our site, such as ECM proteoglycans, ECM-receptor interaction, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with COMP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ECM proteoglycans
MATN4; BGNA; LRP4; HAPLN1; FMOD; BGNB; COMP; COL9A3; MATN1; DAG1
ECM-receptor interaction
LAMA3; HMMR; THBS4; ITGA10; COL3A1; COL6A1; COL4A5; LAMB1; ITGB3; COL5A1
Extracellular matrix organization
COL3A1; P3H2; LTBP4; ADAMTS1; TLL1; TLL2; ADAM9; DDR1; LEPREL1; ICAM4
Focal Adhesion
RAF1B; PDGFC; XIAP; MYLK3; PAK1; PDPK1B; PPP1CAA; RAC1B; THBS3A; FLNA
Integrin cell surface interactions
LOC100514666; JAM2B; COL9A1B; COL9A1A; COMP; FBN1; ICAM4; COL23A1; BSG; F11R.2
Malaria
CSF3; SDC2; GYPB; HBA2; CCL2; DARC; TGFB3; THBS3; Ccl12; TLR2
PI3K-Akt signaling pathway
EFNA2; PRP2; LAMC3; CSF1R; LOC608458; COMP; CSH2; CSF3; CDC37; EFNA4

Protein Function

COMP has several biochemical functions, for example, calcium ion binding, collagen binding, extracellular matrix structural constituent. Some of the functions are cooperated with other proteins, some of the functions could acted by COMP itself. We selected most functions COMP had, and list some proteins which have the same functions with COMP. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein CDH15; S100A1; CD69; CDH17; MBL1; ACTN3; MEX3B; SNCB; KCNIP3; MELK
Function collagen binding
Related Protein SERPINH2; CCBE1; MRC2; DDR1; TGFBI; PDGFB; DDR2; ADAM9; ITGA2; PCOLCE2
Function extracellular matrix structural constituent
Related Protein IMPG2; CD4; CHI3L1; BGN; LAMA4; ELN; LAMB1; IMPG1; COL11A2; FBLN1
Function heparan sulfate proteoglycan binding
Related Protein AZU1; GPC1A; SLIT2; SEMA5A; HRG; HPSE2; FST; UBE4A; Itgam&Itgb2; GPC1B
Function heparin binding
Related Protein APOB; EPYC; MMP7; CCL5; VEGFA; MDK; SELP; SELL; CCL8; CYR61L1
Function protease binding
Related Protein BCL10; Serpina1c; Cstb; TP53; TNF; VWF; LDLR; TIMP4; ELANE; SERPINB3
Function protein binding
Related Protein FAM19A1; IL7R; EIF5A; TMEM123; KLF15; KLHL7; HRK; CST2; PITX1; PTPN11A

Interacting Protein

COMP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COMP here. Most of them are supplied by our site. Hope this information will be useful for your research of COMP.
ADAMTS12; OTX1; MATN3; ACAN; ADAMTS7

COMP Related Articles

Stanton, GB; Kohler, SJ; et al. Cytogenesis in the Adult Monkey Motor Cortex: Perivascular NG2 Cells Are the Major Adult Born Cell Type. JOURNAL OF COMPARATIVE NEUROLOGY 523:849-868(2015).
Butz, E; Peichl, L; et al. Cone Bipolar Cells in the Retina of the Microbat Carollia perspicillata. JOURNAL OF COMPARATIVE NEUROLOGY 523:963-981(2015).