Recombinant Human COMP Protein, His-tagged

• Cat.No.: COMP-185H
• Product Overview: Recombinant human COMP protein with His tag was expressed in HEK293.

Specification

• Description: The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).
• Source: HEK293
• Species: Human
• Tag: His
• Form: Lyophilized
• Molecular Mass: 82 kDa
• Protein Length: 757
• AA Sequence: MVPDTACVLLLTLAALGASGQGQSP LGSDLGPQMLRELQETNAALQDVRE LLRQQVREITFLKNTVMECDACGMQ QSVRTGLPSVRPLLHCAPGFCFPGV ACIQTESGARCGPCPAGFTGNGSHC TDVNECNAHPCFPRVRCINTSPGFR CEACPPGYSGPTHQGVGLAFAKANK QVCTDINECETGQHNCVPNSVCINT RGSFQCGPCQPGFVGDQASGCQRRA QRFCPDGSPSECHEHADCVLERDGS RSCVCAVGWAGNGILCGRDTDLDGF PDEKLRCPERQCRKDNCVTVPNSGQ EDVDRDGIGDACDPDADGDGVPNEK DNCPLVRNPDQRNTDEDKWGDACDN CRSQKNDDQKDTDQDGRGDACDDDI DGDRIRNQADNCPRVPNSDQKDSDG DGIGDACDNCPQKSNPDQADVDHDF VGDACDSDQDQDGDGHQDSRDNCPT VPNSAQEDSDHDGQGDACDDDDDND GVPDSRDNCRLVPNPGQEDADRDGV GDVCQDDFDADKVVDKIDVCPENAE VTLTDFRAFQTVVLDPEGDAQIDPN WVVLNQGREIVQTMNSDPGLAVGYT AFNGVDFEGTFHVNTVTDDDYAGFI FGYQDSSSFYVVMWKQMEQTYWQAN PFRAVAEPGIQLKAVKSSTGPGEQL RNALWHTGDTESQVRLLWKDPRNVG WKDKKSYRWFLQHRPQVGYIRVRFY EGPELVADSNVVLDTTMRGGRLGVF CFSQENIIWANLRYRCNDTIPEDYE THQLRQA
• Purity: > 98%
• Applications: WB; ELISA; FACS; FC
• Stability: This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
• Storage: At -20 centigrade.
• Concentration: 1 mg/mL
• Storage Buffer: PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
• Reconstitution: Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.

Gene Information

• Gene Name: COMP cartilage oligomeric matrix protein [ Homo sapiens (human) ]
• Official Symbol: COMP
• Synonyms: COMP; cartilage oligomeric matrix protein; cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple) , EDM1, EPD1, PSACH; MED; THBS5; thrombospondin 5; TSP5; thrombospondin-5; pseudoachondroplasia (epiphyseal dysplasia 1, multiple); cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia 1, multiple); cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple); EDM1; EPD1; PSACH; MGC131819; MGC149768
• Gene ID: 1311
• mRNA Refseq: NM_000095
• Protein Refseq: NP_000086
• MIM: 600310
• UniProt ID: P49747