Recombinant Human COMP Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: COMP-566H
• Product Overview: COMP MS Standard C13 and N15-labeled recombinant protein (NP_000086) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 82.9 kDa
• AA Sequence: MVPDTACVLLLTLAALGASGQGQSP LGSDLGPQMLRELQETNAALQDVRE LLRQQVREITFLKNTVMECDACGMQ QSVRTGLPSVRPLLHCAPGFCFPGV ACIQTESGARCGPCPAGFTGNGSHC TDVNECNAHPCFPRVRCINTSPGFR CEACPPGYSGPTHQGVGLAFAKANK QVCTDINECETGQHNCVPNSVCINT RGSFQCGPCQPGFVGDQASGCQRRA QRFCPDGSPSECHEHADCVLERDGS RSCVCAVGWAGNGILCGRDTDLDGF PDEKLRCPERQCRKDNCVTVPNSGQ EDVDRDGIGDACDPDADGDGVPNEK DNCPLVRNPDQRNTDEDKWGDACDN CRSQKNDDQKDTDQDGRGDACDDDI DGDRIRNQADNCPRVPNSDQKDSDG DGIGDACDNCPQKSNPDQADVDHDF VGDACDSDQDQDGDGHQDSRDNCPT VPNSAQEDSDHDGQGDACDDDDDND GVPDSRDNCRLVPNPGQEDADRDGV GDVCQDDFDADKVVDKIDVCPENAE VTLTDFRAFQTVVLDPEGDAQIDPN WVVLNQGREIVQTMNSDPGLAVGYT AFNGVDFEGTFHVNTVTDDDYAGFI FGYQDSSSFYVVMWKQMEQTYWQAN PFRAVAEPGIQLKAVKSSTGPGEQL RNALWHTGDTESQVRLLWKDPRNVG WKDKKSYRWFLQHRPQVGYIRVRFY EGPELVADSNVVLDTTMRGGRLGVF CFSQENIIWANLRYRCNDTIPEDYE THQLRQASGPTRTRPLEQKLISEED LAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: COMP cartilage oligomeric matrix protein [ Homo sapiens (human) ]
• Official Symbol: COMP
• Synonyms: COMP; cartilage oligomeric matrix protein; cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple), EDM1, EPD1, PSACH; MED; THBS5; thrombospondin 5; TSP5; thrombospondin-5; pseudoachondroplasia (epiphyseal dysplasia 1, multiple); cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia 1, multiple); cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple); EDM1; EPD1; PSACH; MGC131819; MGC149768
• Gene ID: 1311
• mRNA Refseq: NM_000095
• Protein Refseq: NP_000086
• MIM: 600310
• UniProt ID: P49747