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COX15

Official Full Name

COX15 homolog, cytochrome c oxidase assembly protein (yeast)
Overview

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3 region.
Synonyms

COX15; COX15 homolog, cytochrome c oxidase assembly protein (yeast); COX15 (yeast) homolog, cytochrome c oxidase assembly protein; cytochrome c oxidase assembly protein COX15 homolog; COX15_HUMAN; cytochrome c oxidase subunit 15;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Mus musculus (Mouse)
Zebrafish

Source

E.coli
E.coli expression system
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	COX15-2395H	Recombinant Human COX15	E.coli	Non		Inquiry
Human	COX15-11486H	Recombinant Human COX15, GST-tagged	E.coli	GST	1-410a.a.	$319 / 25μg
Human	COX15-26362TH	Recombinant Human COX15	Wheat Germ	Non	61 amino acids	Inquiry
Human	COX15-1735H	Recombinant Human COX15 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	COX15-1997HF	Recombinant Full Length Human COX15 Protein, GST-tagged	In Vitro Cell Free System	GST	410 amino acids	Inquiry
Mouse	COX15-3808M	Recombinant Mouse COX15 Protein	Mammalian Cell	His		Inquiry
Mouse	COX15-1909M	Recombinant Mouse COX15 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	COX15-1909M-B	Recombinant Mouse COX15 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mus musculus (Mouse)	RFL3335MF	Recombinant Full Length Mouse Cytochrome C Oxidase Assembly Protein Cox15 Homolog(Cox15) Protein, His-Tagged	E.coli expression system	His	Full Length (1-413)	Inquiry
Zebrafish	COX15-11422Z	Recombinant Zebrafish COX15	Mammalian Cell	His		Inquiry
Chicken	COX15-3815C	Recombinant Chicken COX15	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

COX15 involved in several pathways and played different roles in them. We selected most pathways COX15 participated on our site, such as Electron Transport Chain, Heme biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Electron Transport Chain	ATPIF1;COX6A2;COX6C;SLC25A27;ATP5H;UCP2;SLC25A14;UCP3;NDUFC2-KCTD14
Heme biosynthesis	COX15;COX10;CPOX
Metabolic pathways	NADK2;MAT2AA;COX6C;LPCAT2;MVDA;STT3B;B4GALT2;P4HA1;DSE
Metabolism	CTHL;AK7;SLC25A13;SLC25A20;CLPS;CYP4B1;CYP2K8;DAO;ELA2L
Metabolism of porphyrins	COX15;UGT1B3;UGT1B7;COX10;CPOX;UGT1B2;UGT1B4;UGT1B1;UGT1B5
Oxidative phosphorylation	COX7A3;Atp5g2;PPA1;NDUFB9;SDHA;NDUFS2;ATP5H;NDUFA9;ATP4B
Porphyrin and chlorophyll metabolism	HMBSA;UGT1AB;COX15;UGT1A6;UGT1A9;HMOX1A;UGT1A3;HEPH;ALAD

COX15 has several biochemical functions, for example, contributes_to cytochrome-c oxidase activity, cytochrome-c oxidase activity, oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by COX15 itself. We selected most functions COX15 had, and list some proteins which have the same functions with COX15. You can find most of the proteins on our site.

Function	Related Protein
contributes_to cytochrome-c oxidase activity	COX10;COX15;NDUFA4
cytochrome-c oxidase activity	COX8C;CYB5A;COX7A2L;COX7B2;COX15;COX6B2;COX7C;COX4I1;COX6A1
oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	CYB5R4;COX15
oxidoreductase activity, acting on the CH-CH group of donors	SRD5A2B;TECR;PPP1R2;TM7SF2;TECRL;SRD5A2A;SRD5A3;TECRL2B;DPYDB

COX15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX15 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX15.

CLN3; SLC25A3; SLC25A11; TIMM50; SLC25A24; MRPL14; SFXN4; TMEM65; SFXN1; SLC25A19; COA3