COX15

  • Official Full Name

    COX15 homolog, cytochrome c oxidase assembly protein (yeast)

  • Overview

    Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3 region.

  • Synonyms

    COX15;COX15 homolog, cytochrome c oxidase assembly protein (yeast);COX15 (yeast) homolog, cytochrome c oxidase assembly protein;cytochrome c oxidase assembly protein COX15 homolog;COX15_HUMAN;cytochrome c oxidase subunit 15

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • Chicken
  • Mus musculus
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
COX15-11486H Recombinant Human COX15, GST-tagged E.coli Human GST 1-410a.a.
COX15-11422Z Recombinant Zebrafish COX15 Mammalian Cells Zebrafish His
COX15-1735H Recombinant Human COX15 Protein, GST-tagged Wheat Germ Human GST
COX15-2395H Recombinant Human COX15 E.coli Human Non 448-568 a.a.
COX15-26362TH Recombinant Human COX15 Wheat Germ Human Non 61 amino acids
COX15-3808M Recombinant Mouse COX15 Protein Mammalian Cells Mouse His
COX15-3815C Recombinant Chicken COX15 Mammalian Cells Chicken His
COX15-1909M Recombinant Mouse COX15 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
COX15-1909M-B Recombinant Mouse COX15 Protein Pre-coupled Magnetic Beads HEK293 Mouse
COX15-1997HF Recombinant Full Length Human COX15 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 410 amino acids
RFL3335MF Recombinant Full Length Mouse Cytochrome C Oxidase Assembly Protein Cox15 Homolog(Cox15) Protein, His-Tagged E.coli Mus musculus His Full L. Full Length (1-413)

    Involved Pathway

    COX15 involved in several pathways and played different roles in them. We selected most pathways COX15 participated on our site, such as Electron Transport Chain,Heme biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Heme biosynthesis CPOX,COX10
    Metabolism of porphyrins UGT1B4,UGT1B7,UGT1B3,UGT1B5,CPOX,UGT1B1,COX10,UGT1B2
    Porphyrin and chlorophyll metabolism HCCS,PPOX,CP,FECH,UGT5G1,HMOX1A,UGT2A2,HMOX1,UGT1A6A,HCCSB
    Electron Transport Chain COX8A,SURF1,COX4I1,COX6C,ATP5S,COX11,COX7C,SCO1,COX5B,COX6A2
    Oxidative phosphorylation ATP6V1E2,ATP5O,ATP5G3,NDUFB8,ATP6V1H,ATP6V0A4,UQCRC2B,ATP6V0E2,UQCRC2,UQCR10
    Metabolism APOF,DDAH1,PCBD1,SLC44A5B,CYP2K18,CYP27B1,FTCD,APOBB.1,CYP2V1,CPOX
    Metabolic pathways ABO,EXT2,URAD,H6PD,NDUFC2-KCTD14,ATP6V0C,NDUFB5,ATP6V1E2,GCNT2,ATP6V0A2

    Protein Function

    COX15 has several biochemical functions, for example, contributes_to cytochrome-c oxidase activity,cytochrome-c oxidase activity,oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by COX15 itself. We selected most functions COX15 had, and list some proteins which have the same functions with COX15. You can find most of the proteins on our site.

    Function Related Protein
    oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor CYB5R4
    oxidoreductase activity, acting on the CH-CH group of donors TM7SF2,SRD5A2A,SRD5A3,GCDHB,DPYDB,ACOXL,TECRL,SRD5A2B,TECR,GCDHA
    contributes_to cytochrome-c oxidase activity NDUFA4,COX10
    cytochrome-c oxidase activity COX5B2,COX6A1,COX5AA,CYB5A,COX8C,COX11,COX7A2L,COX7A1,SURF1,COX8A

    Interacting Protein

    COX15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX15 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX15.

    CLN3;SLC25A3;SLC25A11;TIMM50;SLC25A24;MRPL14;SFXN4;TMEM65;SFXN1;SLC25A19;COA3

    Resources

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