|Official Full Name||COX15 homolog, cytochrome c oxidase assembly protein (yeast)|
|Background||Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3 region.|
|Synonyms||COX15; COX15 homolog, cytochrome c oxidase assembly protein (yeast); COX15 (yeast) homolog, cytochrome c oxidase assembly protein; cytochrome c oxidase assembly protein COX15 homolog; COX15_HUMAN; cytochrome c oxidase subunit 15|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
COX15 involved in several pathways and played different roles in them. We selected most pathways COX15 participated on our site, such as Electron Transport Chain, Heme biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Electron Transport Chain||ATP5S; SLC25A27; COX7C; COX8A; COX6A1; UCP3; COX11; COX6B1; COX6A2; SCO1|
|Heme biosynthesis||COX10; CPOX; COX15|
|Metabolic pathways||HDC; PKLR; PPCDC; TPI1; MAT2AL; OAT; GNSA; PLA2G1B; SQLEA; SLC33A1|
|Metabolism||NFYBA; AQP1A.2; G0S2; MOCOS; MPC1; NAALAD2; ATP5S; LYVE1; B3GNT2; DECR1|
|Metabolism of porphyrins||UGT1B2; UGT1B4; UGT1B7; CPOX; UGT1B3; COX15; COX10; UGT1B5; UGT1B1|
|Oxidative phosphorylation||COX8C; ATP5IB; NDUFV2; NDUFB10; mt-Atp8; NDUFA11; NDUFV3; NDUFA3; NDUFS6; NDUFA9|
|Porphyrin and chlorophyll metabolism||UGT1A6B; UGT1A1; UGT1A7; HMOX1; HEPH; UGT1A7C; HMBSA; ALAS1; UGT2B15; P22|
COX15 has several biochemical functions, for example, contributes_to cytochrome-c oxidase activity, cytochrome-c oxidase activity, oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by COX15 itself. We selected most functions COX15 had, and list some proteins which have the same functions with COX15. You can find most of the proteins on our site.
|contributes_to cytochrome-c oxidase activity||COX15; COX10; NDUFA4|
|cytochrome-c oxidase activity||COX6A1; COX5B; COX15; CYB5A; COX5AA; COX8A; COX6B2; COX7A2; COX7C; COX6A2|
|oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor||CYB5R4; COX15|
|oxidoreductase activity, acting on the CH-CH group of donors||TECRL2B; ACOXL; COX15; SRD5A2A; PPP1R2; GCDHB; SRD5A3; DPYDB; TECR; GCDHA|
COX15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX15 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX15.
CLN3; SLC25A3; SLC25A11; TIMM50; SLC25A24; MRPL14; SFXN4; TMEM65; SFXN1; SLC25A19; COA3