COX6C

  • Official Full Name

    cytochrome c oxidase subunit VIc

  • Overview

    Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12.
  • Synonyms

    COX6C; cytochrome c oxidase subunit VIc; cytochrome c oxidase subunit 6C; cytochrome c oxidase polypeptide VIc; cytochrome c oxidase subunit VIc preprotein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Macaca silenus (Lion-tailed macaque)
  • Mouse
  • Mus musculus (Mouse)
  • Nycticebus coucang (Slow loris)
  • Plecturocebus donacophilus (Bolivian gray titi monkey) (Callicebus donacophilus)
  • Pongo pygmaeus (Bornean orangutan)
  • Rat
  • Rhesus Macaque
  • Saimiri sciureus (Common squirrel monkey)
  • Sus scrofa (Pig)
  • Tarsius syrichta (Philippine tarsier)
  • Trachypithecus cristatus (Silvered leaf-monkey) (Presbytis cristata)
  • Vicugna pacos (Alpaca) (Lama pacos)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human COX6C-11498H Recombinant Human COX6C, GST-tagged E.coli GST 1-75a.a.
Human COX6C-1758H Recombinant Human COX6C Protein, GST-tagged Wheat Germ GST
Human COX6C-7327HCL Recombinant Human COX6C 293 Cell Lysate HEK293 N/A
Human COX6C-621H Recombinant Human COX6C Protein, His/GST-tagged E.coli His/GST Met1~Lys75
Human COX6C-5309H Recombinant Human COX6C Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human COX6C-2013HF Recombinant Full Length Human COX6C Protein, GST-tagged In Vitro Cell Free System GST 75 amino acids
Mouse COX6C-3821M Recombinant Mouse COX6C Protein Mammalian Cell His
Mouse COX6C-1918M-B Recombinant Mouse COX6C Protein Pre-coupled Magnetic Beads HEK293
Mouse Cox6c-622M Recombinant Mouse Cox6c Protein, His/GST-tagged E.coli His/GST Met1~Lys76
Mouse COX6C-1918M Recombinant Mouse COX6C Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Cox6c-929M Recombinant Mouse Cox6c Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat COX6C-1556R Recombinant Rat COX6C Protein Mammalian Cell His
Rat COX6C-1213R-B Recombinant Rat COX6C Protein Pre-coupled Magnetic Beads HEK293
Rat COX6C-1213R Recombinant Rat COX6C Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bos taurus (Bovine) RFL12218BF Recombinant Full Length Bovine Cytochrome C Oxidase Subunit 6C(Cox6C) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-74)
Homo sapiens (Human) RFL12723HF Recombinant Full Length Human Cytochrome C Oxidase Subunit 6C(Cox6C) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-75)
Macaca silenus (Lion-tailed macaque) RFL23385MF Recombinant Full Length Macaca Silenus Cytochrome C Oxidase Subunit 6C(Cox6C) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-75)
Mus musculus (Mouse) RFL2858MF Recombinant Full Length Mouse Cytochrome C Oxidase Subunit 6C(Cox6C) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-76)
Nycticebus coucang (Slow loris) RFL30834NF Recombinant Full Length Nycticebus Coucang Cytochrome C Oxidase Subunit 6C(Cox6C) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-75)
Plecturocebus donacophilus (Bolivian gray titi monkey) (Callicebus donacophilus) RFL34939PF Recombinant Full Length Callicebus Donacophilus Cytochrome C Oxidase Subunit 6C(Cox6C) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-75)
Pongo pygmaeus (Bornean orangutan) RFL29017PF Recombinant Full Length Pongo Pygmaeus Cytochrome C Oxidase Subunit 6C(Cox6C) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-75)
Rhesus Macaque COX6C-994R Recombinant Rhesus monkey COX6C Protein, His-tagged Mammalian Cell His
Rhesus Macaque COX6C-819R-B Recombinant Rhesus Macaque COX6C Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque COX6C-819R Recombinant Rhesus Macaque COX6C Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Saimiri sciureus (Common squirrel monkey) RFL13798SF Recombinant Full Length Saimiri Sciureus Cytochrome C Oxidase Subunit 6C(Cox6C) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-75)
Sus scrofa (Pig) RFL35127SF Recombinant Full Length Pig Cytochrome C Oxidase Subunit 6C(Cox6C) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-76)
Tarsius syrichta (Philippine tarsier) RFL7248TF Recombinant Full Length Tarsius Syrichta Cytochrome C Oxidase Subunit 6C(Cox6C) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-75)
Trachypithecus cristatus (Silvered leaf-monkey) (Presbytis cristata) RFL25692TF Recombinant Full Length Trachypithecus Cristatus Cytochrome C Oxidase Subunit 6C(Cox6C) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-75)
Vicugna pacos (Alpaca) (Lama pacos) RFL25108VF Recombinant Full Length Lama Guanicoe Pacos Cytochrome C Oxidase Subunit 6C(Cox6C) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-76)
Zebrafish COX6C-8002Z Recombinant Zebrafish COX6C Mammalian Cell His
Chicken COX6C-4204C Recombinant Chicken COX6C Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

COX6C involved in several pathways and played different roles in them. We selected most pathways COX6C participated on our site, such as Alzheimers disease, Cardiac muscle contraction, Electron Transport Chain, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX6C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Alzheimers diseaseUQCRB;SDHC;NDUFB2;GNAQ;PLCB3;GRIN1;NDUFS1;NDUFC2;IL1B
Cardiac muscle contractionCACNA2D3;ATP1A3B;COX7B2;CACNA2D1;COX5B2;SLC9A1;ATP1A1;TNNC1;ATP1B4
Electron Transport ChainCOX5B;COX6C;ATP5S;SCO1;NDUFC2-KCTD14;COX8A;SLC25A14;COX7C;NDUFS7
Gene ExpressionNFIX;ZNF468;EIF2S1A;COX7C;PDCD7;PUS7;DNMT3B;CBX3A;C2orf29
Generic Transcription PathwayNR5A1A;ZNF559;KRBA1;NR2F1A;ZNF550;ZNF670;ZNF10;ZNF571;ZNF285A
Huntingtons diseaseVDAC1;COX7A2;TFAM;TBP;DNAI2;NDUFC2;NDUFA3;NDUFA1;UCP1
Metabolic pathwaysCOX15;ALDH1B1;HSD3B4;AMDHD1;PNPO;ACSM3;NDUFB10;NT5C2B;INPP4A
MetabolismSULT1B1;ABHD3;PNP5B;APOA4B.1;CYP2U1;ARL2;CRAT;COX10;NDUFAF4

COX6C has several biochemical functions, for example, cytochrome-c oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COX6C itself. We selected most functions COX6C had, and list some proteins which have the same functions with COX6C. You can find most of the proteins on our site.

Function Related Protein
cytochrome-c oxidase activityCOX8C;COX6A1;COX15;COX6B1;COX6A2;COX8A;COX5AA;COX11;COA6

COX6C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX6C here. Most of them are supplied by our site. Hope this information will be useful for your research of COX6C.

MT-CO2; GTF2F2; PHB; PTN; RCHY1; NDUFB8; MT-CO1; COX5A; HTT; CRK; CAPZA2; UQCRFS1; RAB2A; COX6A2; SURF1; LRRK2; P; TIMM21

Research Area

Related articles

Ren, JC; Rebrin, I; et al. Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 401:64-68(2010).
Rahman, S; Taanman, JW; et al. A missense mutation of cytochrome oxidase subunit II causes defective assembly and myopathy. AMERICAN JOURNAL OF HUMAN GENETICS 65:1030-1039(1999).
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