COX6C Protein


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Official Full Name cytochrome c oxidase subunit VIc
Background Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12.
Synonyms COX6C; cytochrome c oxidase subunit VIc; cytochrome c oxidase subunit 6C; cytochrome c oxidase polypeptide VIc; cytochrome c oxidase subunit VIc preprotein
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human COX6C-11498H Recombinant Human COX6C, GST-tagged E.coli GST
    Human COX6C-1758H Recombinant Human COX6C Protein, GST-tagged Wheat Germ GST
    Human COX6C-5309H Recombinant Human COX6C Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human COX6C-621H Recombinant Human COX6C Protein, His/GST-tagged E.coli His/GST
    Human COX6C-7327HCL Recombinant Human COX6C 293 Cell Lysate HEK293 N/A
    Mouse COX6C-3821M Recombinant Mouse COX6C Protein Mammalian Cell His
    Mouse Cox6c-622M Recombinant Mouse Cox6c Protein, His/GST-tagged E.coli His/GST
    Mouse Cox6c-929M Recombinant Mouse Cox6c Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat COX6C-1556R Recombinant Rat COX6C Protein Mammalian Cell His
    Rhesus Macaque COX6C-994R Recombinant Rhesus monkey COX6C Protein, His-tagged Mammalian Cell His
    Chicken COX6C-4204C Recombinant Chicken COX6C Mammalian Cell His
    Zebrafish COX6C-8002Z Recombinant Zebrafish COX6C Mammalian Cell His

    COX6C involved in several pathways and played different roles in them. We selected most pathways COX6C participated on our site, such as Alzheimers disease, Cardiac muscle contraction, Electron Transport Chain, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX6C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alzheimers disease ERN1; CALM1; PLCB4; ATP5A1; NDUFS4; CALM2; COX5B; APAF1; ADAM10; NDUFB4
    Cardiac muscle contraction COX8A; CACNA1C; ATP1B4; TPM2; TNNT2A; SLC9A1; COX5A; CACNB2; CACNA1SA; COX7A2
    Electron Transport Chain ATP5H; COX5B; COX11; COX7C; SURF1; UCP2; SCO1; COX6B1; COX4I1; COX6A2
    Gene Expression TYW5; SLBP; ZFP2; SUDS3; COBRA1; Txn1; ZNF583; POLR3C; CCNC; MED16
    Generic Transcription Pathway ZNF202; ZNF334; ZNF498; ZNF706; ZNF773; NR1D2A; ZNF200; ZNF671; ZNF490; CTGF
    Huntingtons disease NDUFV2; PLCB1; UQCR11; COX8C; UQCRC1; POLR2C; SDHD; NDUFA11; NDUFA7; NDUFS1
    Metabolic pathways NDUFAB1A; MTHFS; MTMR3; LPIN1; PPT2; FOLH1; MAT2A; NOS2A; POLE2; RRM2
    Metabolism Sult2a6; COX7C; HSD17B11; CSNK1G2; ARL2; KCNG4; HS3ST4; COX18; BCKDK; FAM213B

    COX6C has several biochemical functions, for example, cytochrome-c oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COX6C itself. We selected most functions COX6C had, and list some proteins which have the same functions with COX6C. You can find most of the proteins on our site.

    Function Related Protein
    cytochrome-c oxidase activity COX7A2A; COX5AA; COX6A2; COX7C; CYB5A; COX5A; COA6; COX8C; COX6A1; COX15

    COX6C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX6C here. Most of them are supplied by our site. Hope this information will be useful for your research of COX6C.


    Ren, JC; Rebrin, I; et al. Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 401:64-68(2010).
    Rahman, S; Taanman, JW; et al. A missense mutation of cytochrome oxidase subunit II causes defective assembly and myopathy. AMERICAN JOURNAL OF HUMAN GENETICS 65:1030-1039(1999).

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