CRHR1

  • Official Full Name

    corticotropin releasing hormone receptor 1

  • Overview

    This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants, one of which represents a read-through transcript with the neighboring gene MGC57346. [provided by RefSeq, Jan 2012]
  • Synonyms

    CRHR1; corticotropin releasing hormone receptor 1; CRF1; CRHR; CRF-R; CRFR1; CRF-R1; CRFR-1; CRH-R1; CRHR1L; CRHR1f; CRF-R-1; CRH-R-1; CRH-R1h; corticotropin-releasing factor receptor 1; CRH receptor 1 variant B; seven transmembrane helix receptor; corticotropin-releasing hormone receptor 1; corticotropin-releasing factor type 1 receptor; corticotropin releasing hormone receptor variant 1e; corticotropin releasing hormone receptor variant 1g;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Gallus gallus (Chicken)
  • Human
  • Macaca mulatta (Rhesus macaque)
  • Mouse
  • Mus musculus (Mouse)
  • Ovis aries (Sheep)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Xenopus laevis (African clawed frog)
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • Flag
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CRHR1-27818TH Recombinant Human CRHR1 Wheat Germ N/A 98 amino acids
Human CRHR1-1867H Recombinant Human CRHR1 Protein, GST-tagged Wheat Germ GST
Human CRHR1-185H Recombinant Human CRHR1 protein Wheat Germ N/A
Human CRHR1-184H Recombinant Human CRHR1 Mammalian Cell His
Human CRHR1-2309HF Recombinant Full Length Human CRHR1 Protein, GST-tagged In Vitro Cell Free System GST 415 amino acids
Human CRHR1-1369H Recombinant Human CRHR1 Protein (23-121 aa), His-tagged Yeast His 23-121 aa
Human CRHR1-424H Recombinant Human CRHR1 Protein (24-121 aa), GST-tagged E.coli GST 24-121 aa
Human CRHR1-2731H Recombinant Human CRHR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CRHR1-1122HFL Recombinant Human CRHR1 protein, His&Flag-tagged HEK293 His&Flag 1-444 aa
Human CRHR1-2731H-B Recombinant Human CRHR1 Protein Pre-coupled Magnetic Beads HEK293
Human CRHR1-585HF Recombinant Full Length Human CRHR1 Protein In Vitro Cell Free System 444 amino acids
Mouse Crhr1-842M Recombinant Mouse Crhr1 Protein, His-tagged E.coli N-His Ser24-Cys149
Rat CRHR1-1597R Recombinant Rat CRHR1 Protein Mammalian Cell His
Rat CRHR1-1254R Recombinant Rat CRHR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CRHR1-1254R-B Recombinant Rat CRHR1 Protein Pre-coupled Magnetic Beads HEK293
Rat Crhr1-843R Recombinant Rat Crhr1 Protein, His-tagged E.coli N-His Ser24-Cys149
Gallus gallus (Chicken) RFL34398GF Recombinant Full Length Chicken Corticotropin-Releasing Factor Receptor 1(Crhr1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (29-420)
Macaca mulatta (Rhesus macaque) RFL31327MF Recombinant Full Length Macaca Mulatta Corticotropin-Releasing Factor Receptor 1(Crhr1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (24-415)
Mus musculus (Mouse) RFL29982MF Recombinant Full Length Mouse Corticotropin-Releasing Factor Receptor 1(Crhr1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (24-415)
Ovis aries (Sheep) RFL20126OF Recombinant Full Length Sheep Corticotropin-Releasing Factor Receptor 1(Crhr1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (24-415)
Rattus norvegicus (Rat) RFL12425RF Recombinant Full Length Rat Corticotropin-Releasing Factor Receptor 1(Crhr1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (24-415)
Rhesus Macaque CRHR1-1028R Recombinant Rhesus monkey CRHR1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CRHR1-853R Recombinant Rhesus Macaque CRHR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CRHR1-853R-B Recombinant Rhesus Macaque CRHR1 Protein Pre-coupled Magnetic Beads HEK293
Xenopus laevis (African clawed frog) RFL1875XF Recombinant Full Length Xenopus Laevis Corticotropin-Releasing Factor Receptor 1(Crhr1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (25-415)
Chicken CRHR1-5894C Recombinant Chicken CRHR1 Mammalian Cell His
Kit-0890 TCF/LEF Reporter Kit N/A
Kit-1182 cAMP CRHR1 CHO-K1 GPCR Assay Kit N/A
Kit-1183 CRHR1 CHO-K1 β-Arrestin GPCR Assay Kit N/A
Kit-1033 Urease Activity Assay Kit (Colorimetric) N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CRHR1 involved in several pathways and played different roles in them. We selected most pathways CRHR1 participated on our site, such as Class B/2 (Secretin family receptors), Corticotropin-releasing hormone, G alpha (s) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRHR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Class B/2 (Secretin family receptors)CD97;ADM;GNB5B;PTH;ADCYAP1R1;EMR4;GNB3B;GCGB;ADCYAP1
Corticotropin-releasing hormoneCRH;CRHR2;CYP11A1;TBX19;IVL;JUNB;CASP12;TRIM28;ECE1
G alpha (s) signalling eventsPTHLH;RLN3A;INSL3;GHRH;VIP2;GCGB;CRHR2;SCT;GCGA
GPCR downstream signalingFGD4A;DRD4;RGS6;TAS2R16;CCR6;SOUL3;NPS;EDNRAB;CNR2
GPCR ligand bindingACKR4;GPR120;PTHRP2;NPS;PTGDR2;ADCYAP1R1;FPR-RS6;GRP;GPRC6A
GPCRs, Class B Secretin-likeCRHR2;CRHR1;EMR2;CD97;CALCRL;ELTD1;LPHN1;ADCYAP1R1;EMR1
Long-term depressionGUCY1A3;PPP1R17;GNAI2;PPP2CB;PRKG2;PRKCB;HRAS;GNA13;PLA2G4A
Myometrial Relaxation and Contraction PathwaysRXFP2;IGFBP4;CNN2;PKIB;CORIN;RGS14;GPR182;MAFF;RGS4

CRHR1 has several biochemical functions, for example, G-protein alpha-subunit binding, corticotrophin-releasing factor receptor activity, corticotropin-releasing hormone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CRHR1 itself. We selected most functions CRHR1 had, and list some proteins which have the same functions with CRHR1. You can find most of the proteins on our site.

Function Related Protein
G-protein alpha-subunit bindingRGS19;HTR2B;OPRM1;IGF1R;F2RL1;RIC8;RIC8A;AGTR1A;PPP5C
corticotrophin-releasing factor receptor activityCRHR2;CRHR1
corticotropin-releasing hormone bindingCRHBP;CRHR1
corticotropin-releasing hormone receptor activityCRHR2;CRHR1
protein bindingABCA1;TERF2;EIF3D;TET3;IL23R;MICAL1;WIBG;VPS33B;IL18R1
protein complex bindingDLG4;BAX;MYO7A;ADM2;DRD1;PLK2;MTHFR;VHLL;THRA

CRHR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRHR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CRHR1.

CRH; SRPK1; CALM1

Research Area

Related articles

Liguori, G; Squillacioti, C; et al. Presence and Distribution of Urocortin and its Receptors in the Epididymis of Alpaca (Vicugna pacos). ANATOMIA HISTOLOGIA EMBRYOLOGIA 44:66-71(2015).
Squillacioti, C; De Luca, A; et al. Presence and Distribution of Urocortin and Corticotrophin-Releasing Hormone Receptors in the Bovine Thyroid Gland. ANATOMIA HISTOLOGIA EMBRYOLOGIA 43:429-434(2014).
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