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CYP7A1

  • Official Full Name

    cytochrome P450, family 7, subfamily A, polypeptide 1

  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010]
  • Synonyms

    CYP7A1; cytochrome P450, family 7, subfamily A, polypeptide 1; CP7A; CYP7; CYPVII; cholesterol 7-alpha-monooxygenase; cytochrome P450 7A1; cholesterol 7-alpha-hydroxylase; cytochrome P450, subfamily VIIA polypeptide 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CYP7A1-2291H Recombinant Human CYP7A1 Protein, GST-tagged Wheat Germ GST
Human CYP7A1-7099HCL Recombinant Human CYP7A1 293 Cell Lysate HEK293 N/A
Human CYP7A1-2425H Recombinant Human CYP7A1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human CYP7A1-2872H Recombinant Human CYP7A1 protein, His-tagged E.coli His 188-387 aa
Human CYP7A1-708H-B Recombinant Human CYP7A1 Protein Pre-coupled Magnetic Beads HEK293
Human CYP7A1-552HFL Recombinant Full Length Human CYP7A1 Protein, C-Flag-tagged Mammalian cells Flag
Human CYP7A1-708H Recombinant Human CYP7A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CYP7A1-4232M Recombinant Mouse CYP7A1 Protein Mammalian Cell His
Mouse Cyp7a1-1440M Recombinant Mouse Cyp7a1 protein, His & T7-tagged E.coli His/T7 Leu227~Leu467 (Accession # Q64505)
Mouse Cyp7a1-2425M Recombinant Mouse Cyp7a1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse CYP7A1-2163M-B Recombinant Mouse CYP7A1 Protein Pre-coupled Magnetic Beads HEK293
Mouse CYP7A1-2163M Recombinant Mouse CYP7A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Cyp7a1-1441R Recombinant Rat Cyp7a1 protein, His & T7-tagged E.coli His/T7 Phe109~Lys383 (Accession # P18125)
Rat CYP7A1-1757R Recombinant Rat CYP7A1 Protein Mammalian Cell His
Rat CYP7A1-1416R-B Recombinant Rat CYP7A1 Protein Pre-coupled Magnetic Beads HEK293
Rat CYP7A1-1416R Recombinant Rat CYP7A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CYP7A1-1166R Recombinant Rhesus monkey CYP7A1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CYP7A1-991R-B Recombinant Rhesus Macaque CYP7A1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CYP7A1-991R Recombinant Rhesus Macaque CYP7A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken CYP7A1-1149C Recombinant Chicken CYP7A1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CYP7A1 Related Articles

CYP7A1 involved in several pathways and played different roles in them. We selected most pathways CYP7A1 participated on our site, such as Bile acid and bile salt metabolism, Bile secretion, Biological oxidations, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP7A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Bile acid and bile salt metabolismAKR1C2;NCOA2;SLC27A2;CYP7A1;Alb;CYP46A1;AKR1C4;SCP2B;BRSK2
Bile secretionSLC22A7;ADCY9;AQP8;ADCY6;SULT2A1;PRKACB;ABCB1;BAAT;SLC4A4
Biological oxidationsCYP3A7;CYP2W1;CYP2E1;UGT1B3;CYP3C4;NCOA2;ADH7;SULT1C4;CYP2A6
Cytochrome P450 - arranged by substrate typeCYP2E1;CYP3A5;CYP11B2;CYP2B6;CYP27A1;CYP4F12;POMCB;CYP21A2;CYP2C19
Drug Induction of Bile Acid PathwaySLC51B;ABCC2;NR1I3;SLCO1B1;CYP7A1;NR1I2
Endogenous sterolsCYP11B2;CYP17A1;FDX1L;CYP46A1;CYP27A1;CYP8B2;CYP21A2;FDX1;CYP51A1
Fatty acid, triacylglycerol, and ketone body metabolismACSF3;ANKRD1;CPT1B;ACOT7;YAP1;CTGF;AGPAT1;SLC25A20;CDK19
Metabolic pathwaysPLCB4;CSGALNACT2;HMGCR;HPDB;CKMT2;CSAD;PIP5K1AA;IMPA1;NDUFV2

CYP7A1 has several biochemical functions, for example, cholesterol 7-alpha-monooxygenase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP7A1 itself. We selected most functions CYP7A1 had, and list some proteins which have the same functions with CYP7A1. You can find most of the proteins on our site.

Function Related Protein
cholesterol 7-alpha-monooxygenase activityCYP7A1A;CYP7A1
heme bindingCYP3A4;PTGS1;HBA1;CYP46A1.1;CYP2J6;MB;HBD;CYP4F3;HBBE2
iron ion bindingCYP4A11;ALOX15B;ACO2;CYP2K22;CYP2A6;SC5DL;CYP2D26;CYP2S1;JHDM1D

CYP7A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP7A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP7A1.

Reiner, Z; et al. Resistance and intolerance to statins. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES 24:1057-1066(2014).
Kong, B; Guo, GL; et al. Soluble Expression of Disulfide Bond Containing Proteins FGF15 and FGF19 in the Cytoplasm of Escherichia coli. PLOS ONE 9:-(2014).
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