DCD
-
Official Full Name
dermcidin -
Overview
This gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. -
Synonyms
DCD;dermcidin;AIDD;DCD 1;diffusible survival/evasion peptide;DSEP;HCAP;PIF;preproteolysin;proteolysis inducing factor;survival promoting peptide;DCD-1
Recombinant Proteins
- Streptomyces coelicolor A3(2)
- Human
- E.Coli/Yeast
- Wheat Germ
- HEK293
- E.coli
- Yeast
- In Vitro Cell Free System
- Protein Conjugation
- Mammalian Cells
- His
- GST
- Fc
- Non
- B2M
- Flag
- Avi
Involved Pathway
DCD involved in several pathways and played different roles in them. We selected most pathways DCD participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DCD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DCD has several biochemical functions, for example, peptidase activity,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DCD itself. We selected most functions DCD had, and list some proteins which have the same functions with DCD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | C12orf68,EIF1AX,KLC1,CCDC6,MST1,MECP2,MYOCD,PMEPA1,FAM123A,PIK3IP1 |
| poly(A) RNA binding | DDX28,RRP12,HIST1H1C,PATL1,MRPS28,ZC3H14,RC3H2,GRWD1,MAK16,UTP15 |
| peptidase activity | PCSK7,CTSSA,KLK1B26,PSMA6B,SPPL3,PRSS59.2,TMPRSS4A,MASP1,AGA,PSD |
Interacting Protein
DCD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCD here. Most of them are supplied by our site. Hope this information will be useful for your research of DCD.
APPBP2;PPP2R2B;SSSCA1;RAD51D;CD2BP2;FAM107A;VDAC1;YWHAZ;ILK;EIF2B1;TNFRSF14;INPP5K;CDC42BPB;IL24;midostaurin;MED26
Resources
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References
- Bancovik, J; Moreira, DF; et al. Dermcidin exerts its oncogenic effects in breast cancer via modulation of ERBB signaling. BMC CANCER 15:-(2015).
- Sanchez-Escuredo, A; Alsina, A; et al. Polyclonal Versus Monoclonal Induction Therapy in a Calcineurin Inhibitor-Free lmmunosuppressive Therapy in Renal Transplantation: A Comparison of Efficacy and Costs. TRANSPLANTATION PROCEEDINGS 47:45-49(2015).
