| Official Full Name | decapping mRNA 2 |
| Background | The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5 end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011] |
| Synonyms | DCP2; decapping mRNA 2; NUDT20; m7GpppN-mRNA hydrolase; hDpc; mRNA-decapping enzyme 2; DCP2 decapping enzyme homolog; nudix (nucleoside diphosphate linked moiety X)-type motif 20; |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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dcp2 involved in several pathways and played different roles in them. We selected most pathways dcp2 participated on our site, such as ATF4 activates genes, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Deadenylation-dependent mRNA decay, which may be useful for your reference. Also, other proteins which involved in the same pathway with dcp2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ATF4 activates genes | DDIT3; EXOSC8; KCNA3; DCP2 |
| Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | ZFP36L1B; ZFP36L1A; MAPKAPK2B; DCP2; EXOSC8; ZFP36L1 |
| Deadenylation-dependent mRNA decay | EIF4A2; PAIP1; EIF4EB; D1BWG0212E; TNKS1BP1; EIF4A1; LSM6; DDX6; EIF4E; EXOSC8 |
| Gene Expression | PUS7; WDR4; CSTF2; TSEN34; ZNF354B; HENMT1; ZNF215; RORAA; EFCAB11; ZNF597 |
| KSRP (KHSRP) binds and destabilizes mRNA | EXOSC8; DCP2; KHSRP |
| Metabolism of proteins | GFER; DMBT1; EEF1B2; DHPS; DPAGT1; MUCL1; IGFBP2B; ST6GALNAC2; GALNT6; WDR85 |
| PERK regulates gene expression | EXOSC8; DCP2 |
| RNA degradation | LSM2; EXOSC3; EDC3; PATL1; CNOT4; PABPC1A; TOB1B; PFKMA; PABPC4; DCP1B |
dcp2 has several biochemical functions, for example, RNA binding, exoribonuclease activity, producing 5-phosphomonoesters, m7G(5)pppN diphosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by dcp2 itself. We selected most functions dcp2 had, and list some proteins which have the same functions with dcp2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | TRNAU1APB; NSUN5B; ILF3A; DIS3; NR0B1; HNRPL; OASL2; RPL19; EXOSC7; UBR5 |
| exoribonuclease activity, producing 5-phosphomonoesters | DCP2 |
| m7G(5)pppN diphosphatase activity | DCPS; DCP2; NUDT16 |
| manganese ion binding | GLUL; ME1; DYRK2; TDP2B; PEPD; IMPA1; PPEF2; ENDOU; ARG1; TDP2 |
| protein binding | MAPK7; TMEM41A; DPYSL2; KRT16; BCL2L14; DPYSL4; ARL2BP; AGO2; AQP1; UCP3 |
dcp2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with dcp2 here. Most of them are supplied by our site. Hope this information will be useful for your research of dcp2.
DCP1A; UPF1; EDC4; Edc4; DCP1B
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