dcp2 Protein, decapping mRNA 2

dcp2

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dcp2

Official Full Name decapping mRNA 2
Background The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5 end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
Synonyms DCP2; decapping mRNA 2; NUDT20; m7GpppN-mRNA hydrolase; hDpc; mRNA-decapping enzyme 2; DCP2 decapping enzyme homolog; nudix (nucleoside diphosphate linked moiety X)-type motif 20;
    • Species :
    • Human
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DCP2-1690H Recombinant Human DCP2 Protein (1-385 aa), His-tagged Yeast His
    Human DCP2-11861H Recombinant Human DCP2, His-tagged E.coli His
    Human DCP2-1570H Recombinant Human DCP2 protein E.coli N/A
    Human DCP2-2402H Recombinant Human DCP2 Protein, GST-tagged Wheat Germ GST
    Human DCP2-446HCL Recombinant Human DCP2 cell lysate N/A
    Rhesus Macaque DCP2-1193R Recombinant Rhesus monkey DCP2 Protein, His-tagged Mammalian Cell His
    Zebrafish DCP2-10499Z Recombinant Zebrafish DCP2 Mammalian Cell His

    dcp2 involved in several pathways and played different roles in them. We selected most pathways dcp2 participated on our site, such as ATF4 activates genes, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Deadenylation-dependent mRNA decay, which may be useful for your reference. Also, other proteins which involved in the same pathway with dcp2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ATF4 activates genes DDIT3; EXOSC8; KCNA3; DCP2
    Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA ZFP36L1B; ZFP36L1A; MAPKAPK2B; DCP2; EXOSC8; ZFP36L1
    Deadenylation-dependent mRNA decay EIF4A2; PAIP1; EIF4EB; D1BWG0212E; TNKS1BP1; EIF4A1; LSM6; DDX6; EIF4E; EXOSC8
    Gene Expression PUS7; WDR4; CSTF2; TSEN34; ZNF354B; HENMT1; ZNF215; RORAA; EFCAB11; ZNF597
    KSRP (KHSRP) binds and destabilizes mRNA EXOSC8; DCP2; KHSRP
    Metabolism of proteins GFER; DMBT1; EEF1B2; DHPS; DPAGT1; MUCL1; IGFBP2B; ST6GALNAC2; GALNT6; WDR85
    PERK regulates gene expression EXOSC8; DCP2
    RNA degradation LSM2; EXOSC3; EDC3; PATL1; CNOT4; PABPC1A; TOB1B; PFKMA; PABPC4; DCP1B

    dcp2 has several biochemical functions, for example, RNA binding, exoribonuclease activity, producing 5-phosphomonoesters, m7G(5)pppN diphosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by dcp2 itself. We selected most functions dcp2 had, and list some proteins which have the same functions with dcp2. You can find most of the proteins on our site.

    Function Related Protein
    RNA binding TRNAU1APB; NSUN5B; ILF3A; DIS3; NR0B1; HNRPL; OASL2; RPL19; EXOSC7; UBR5
    exoribonuclease activity, producing 5-phosphomonoesters DCP2
    m7G(5)pppN diphosphatase activity DCPS; DCP2; NUDT16
    manganese ion binding GLUL; ME1; DYRK2; TDP2B; PEPD; IMPA1; PPEF2; ENDOU; ARG1; TDP2
    protein binding MAPK7; TMEM41A; DPYSL2; KRT16; BCL2L14; DPYSL4; ARL2BP; AGO2; AQP1; UCP3

    dcp2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with dcp2 here. Most of them are supplied by our site. Hope this information will be useful for your research of dcp2.

    DCP1A; UPF1; EDC4; Edc4; DCP1B

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