DEFB4A

  • Official Full Name

    defensin, beta 4A

  • Overview

    Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation.
  • Synonyms

    DEFB4A; DEFB-2; DEFB102; DEFB2; DEFB4; HBD-2; SAP1; BD-2; beta-defensin 4A; defensin, beta 2; defensin, beta 4; skin-antimicrobial peptide 1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Human
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DEFB4A-037H Active Recombinant Human Defensin, Beta 4A Human N/A
Human DEFB4A-5192H Active Recombinant Human DEFB4A protein E.coli N/A 50 amino acids
Human DEFB4A-133D Active Recombinant Human DEFB4A Protein (50 aa) E.coli 50
Human DEFB4A-5190H Recombinant Human Defensin, Beta 4A Human N/A
Human DEFB4A-27476TH Recombinant Human DEFB4A protein E.coli N/A 41
Human DEFB4A-4907H Recombinant Human Defensin, Beta 4A E.coli N/A
Human DEFB4A -5387H Recombinant Human Defensin, Beta 4A E.coli N/A
Human DEFB4A-632H Recombinant Human DEFB4A protein, His & GST-tagged E.coli His/GST Gly24~Pro64
Human DEFB4A-5133H Recombinant Human DEFB4A Protein, GST-tagged Wheat Germ GST
Human DEFB4A-2815H Recombinant Human DEFB4A protein, GST-tagged E.coli GST 1-64aa
Human DEFB4A-1333H Recombinant Human DEFB4A Protein, His-tagged E.coli N-His Gly24-Pro64
Human DEFB4A-1948H Recombinant Human DEFB4A Protein (Gly24-Pro64), N-GST tagged E.coli N-GST Gly24-Pro64
Human DEFB4A-91H Recombinant Human DEFB4A Protein E.coli 41 amino acid
Human DEFB4A-3752HF Recombinant Full Length Human DEFB4A Protein, GST-tagged In Vitro Cell Free System GST 64 amino acids
Human DEFB4A-540H Active Recombinant Human DEFB4A Protein E.coli Tag Free
Rhesus Macaque DEFB4A-1239R Recombinant Rhesus monkey DEFB4A Protein, His-tagged Mammalian Cell His
Rhesus Macaque DEFB4A-1064R Recombinant Rhesus Macaque DEFB4A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DEFB4A-1064R-B Recombinant Rhesus Macaque DEFB4A Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

DEFB4A involved in several pathways and played different roles in them. We selected most pathways DEFB4A participated on our site, such as Beta defensins, Defensins, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with DEFB4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Beta defensinsDEFB125;DEFB106A;DEFB121;CCR6;DEFB103A;DEFB119;DEFB1;DEFB104A;DEFB4B
DefensinsDEFB121;DEFA3;DEFB129;DEFA5;DEFA6;DEFB104A;DEFA1;DEFB4B;DEFB4A
Immune SystemPANX1B;LILRA2;GBP2;LILRB1;TRIM6;LILRB4;TANK;KIF22;IFITM3
Innate Immune SystemDEFA6;CD300LB;DEFB4B;POLR3F;PELI2;AGER;DEFB4A;NCKIPSD;RCA2.1

DEFB4A has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by DEFB4A itself. We selected most functions DEFB4A had, and list some proteins which have the same functions with DEFB4A. You can find most of the proteins on our site.

Function Related Protein

DEFB4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DEFB4A here. Most of them are supplied by our site. Hope this information will be useful for your research of DEFB4A.

  • Q&As
  • Reviews

Q&As (6)

Ask a question
How can the structure of DEFB4A be evaluated? 05/25/2023

DEFB4A has a typical β-defensin structure consisting of a cysteine-rich mature peptide region and a positively charged N-terminal region. This structure allows it to bind and destroy the cell membranes of pathogenic microorganisms.

Which biomolecules can be used as molecular markers for DEFB4A? 03/16/2023

Biomolecules that can be used as molecular markers for DEFB4A include its mRNA and protein expression products in tissues and cells, as well as other biomolecules (e.g., receptors, signal transduction molecules, etc.) that interact with it.

What diseases are associated with the aberrant expression of DEFB4A? 07/26/2022

The abnormal expression of DEFB4A is associated with a variety of inflammatory and infectious diseases, such as psoriasis, atopic dermatitis, chronic sinusitis, etc. In addition, the expression of DEFB4A has also been found to be associated with the occurrence and progression of certain tumors.

What are the treatment strategies for DEFB4A? 03/07/2021

Therapeutic strategies for DEFB4A include modulating its expression levels, enhancing its antimicrobial activity, and developing inhibitors targeting its signaling pathway. Treatment depends on the type and severity of the disease.

How can I detect the expression level of DEFB4A? 11/15/2020

The mRNA and protein expression levels of DEFB4A in tissues and cells can be detected by real-time PCR, immunohistochemistry, and western blotting.

What is the interaction between DEFB4A and other biomolecules? 02/01/2020

There are interactions between DEFB4A and other biomolecules. For example, it can bind to the cell membrane of pathogenic microorganisms and disrupt their integrity to exert antimicrobial effects, and it can also bind to receptors on the surface of epithelial cells to activate signal transduction pathways and regulate cellular immune responses.

Customer Reviews (3)

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Reviews
06/28/2023

    The structure is very stable and not easy to deteriorate.

    06/01/2023

      The cost is low and the activity is strong, which greatly saves our scientific research costs.

      04/09/2020

        The quality of the DEFB4A is very high, which makes my experiments more smooth and accurate.

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