DIAPH1
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Official Full Name
diaphanous homolog 1 (Drosophila) -
Overview
This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. -
Synonyms
DIAPH1;diaphanous homolog 1 (Drosophila);DFNA1, diaphanous (Drosophila, homolog) 1;protein diaphanous homolog 1;hDIA1;LFHL1;FLJ25265;Deafness autosomal dominant 1;deafness, autosomal dominant 1;DFNA1;DIAP1;DIAP1_HUMAN;diaphanous homolog 1;Diaphanous protein homolog 1;Diaphanous related formin 1;Diaphanous-related formin-1;DRF1;low frequency hearing loss 1;p140DIA;OTTHUMP00000195047;OTTHUMP00000195048;OTTHUMP00000195049;OTTHUMP00000224777;diaphanous-related formin 1;DIA1
Recombinant Proteins
- Human
- Chicken
- Mouse
- Wheat Germ
- Mammalian Cells
- HEK293
- E.coli
- GST
- His
- Non
- DDK
- Myc
- Flag
- Avi
- Fc
Involved Pathway
DIAPH1 involved in several pathways and played different roles in them. We selected most pathways DIAPH1 participated on our site, such as AGE/RAGE pathway,Focal adhesion,G13 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DIAPH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| G13 Signaling Pathway | RHPN2,CIT,SH3RF1,MYBPH,RTKN,CFL2,GNA13,ARHGEF1A,MYL1,TNK2 |
| RHO GTPase Effectors | ABI2,RHOC,SPC24,CLIP1,SGOL2,RHOAE,RHOGA,KNTC1,SKA2,NSL1 |
| Regulation of Actin Cytoskeleton | BDKRB2,PIP5K1A,CFL2L,ITGAX,PDGFD,ACTN4,PFN1,ACTN3,MYH10,ITGA2B |
| RhoA signaling pathway | MKL1,CYR61,ACTA1 |
| RHO GTPases Activate Formins | SKA1,KNTC1,NUF2,MKL1B,ZW10,ZWINT,RHOAE,CCDC99,SPC25,RHOC |
| Shigellosis | WASF1,ATG5,MAPK11,ACTG1,ROCK1,ACTB,CTTN,WASL,RAC1,IKBKB |
| Focal adhesion | LAMB1,TNN,SOS1,VCL,PIK3CB,CCND3,VTNA,COL27A1B,ELK1,PPP1CA |
| AGE/RAGE pathway | DDOST,TIRAP,LGALS3,EGFR,JAK2,CHUK,JUN,MMP13,AGER,MAPK14 |
Protein Function
DIAPH1 has several biochemical functions, for example, Rho GTPase binding,actin binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DIAPH1 itself. We selected most functions DIAPH1 had, and list some proteins which have the same functions with DIAPH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| profilin binding | PCLO,FMNL1,VASP,CTTN,DIAP1,EVL,HTT,WIPF1,CYFIP1,RHOQ |
| Rho GTPase binding | DIAP3,ROCK2,DAAM1,PARD6A,ROCK2B,CDC42BPB,DAPK3,FLNA,DOCK10,FMNL2 |
| actin binding | INPPL1B,TNS4,NRAP,SPTBN2,CLMN,TPM4,FHOD3,MYRIP,VMHC,MYO10 |
| poly(A) RNA binding | RBM10,HSP90AB1,EIF3E,TRMT1L,DDX18,MBNL1,RPSA,ANP32A,BCLAF1,SCAF4 |
| ion channel binding | GPD1L,YWHAH,PACS2,SUMO1,KCNIP1,CALM,RIMS3,CTNNB1,ACTN1,YES1 |
| protein binding | PSKH1,BAG6,ST13,RAB34,SKA3,TNFAIP8L1,COL13A1,NF1,SGOL2,SYF2 |
| identical protein binding | MBIP,AGER,HAND1,LTBR,AIM2,RBM10,ACADM,ITGA2B,CEACAM5,DPP4 |
| receptor binding | HCST,CALCA,EHHADH,FIS1,DDX54,UTS2,HAND2,ANG,CCL17,LAMA1 |
Interacting Protein
DIAPH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DIAPH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DIAPH1.
RHOA;AGER;PPM1F;PKD2;ORF;RHOD;RHOC;RHOB;RHOF;GAS7;WBP4
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References
- Chang, ALS; Atzmon, G; et al. Identification of Genes Promoting Skin Youthfulness by Genome-Wide Association Study. JOURNAL OF INVESTIGATIVE DERMATOLOGY 134:651-657(2014).
- Schoen, CJ; Burmeister, M; et al. Diaphanous homolog 3 (Diap3) Overexpression Causes Progressive Hearing Loss and Inner Hair Cell Defects in a Transgenic Mouse Model of Human Deafness. PLOS ONE 8:-(2013).
