| Description : |
This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
140.2 kDa |
| AA Sequence : |
MEPPGGSLGPGRGTRDKKKGRSPDE LPSAGGDGGKSKKFLERFTSMRIKK EKEKPNSAHRNSSASYGDDPTAQSL QDVSDEQVLVLFEQMLLDMNLNEEK QQPLREKDIIIKREMVSQYLYTSKA GMSQKESSKSAMMYIQELRSGLRDM PLLSCLESLRVSLNNNPVSWVQTFG AEGLASLLDILKRLHDEKEETAGSY DSRNKHEIIRCLKAFMNNKFGIKTM LETEEGILLLVRAMDPAVPNMMIDA AKLLSALCILPQPEDMNERVLEAMT ERAEMDEVERFQPLLDGLKSGTTIA LKVGCLQLINALITPAEELDFRVHI RSELMRLGLHQVLQDLREIENEDMR VQLNVFDEQGEEDSYDLKGRLDDIR MEMDDFNEVFQILLNTVKDSKAEPH FLSILQHLLLVRNDYEARPQYYKLI EECISQIVLHKNGADPDFKCRHLQI EIEGLIDQMIDKTKVEKSEAKAAEL EKKLDSELTARHELQVEMKKMESDF EQKLQDLQGEKDALHSEKQQIATEK QDLEAEVSQLTGEVAKLTKELEDAK KEMASLSAAAITVPPSVPSRAPVPP APPLPGDSGTIIPPPPAPGDSTTPP PPPPPPPPPPLPGGVCISSPPSLPG GTAISPPPPLSGDATIPPPPPLPEG VGIPSPSSLPGGTAIPPPPPLPGSA RIPPPPPPLPGSAGIPPPPPPLPGE AGMPPPPPPLPGGPGIPPPPPFPGG PGIPPPPPGMGMPPPPPFGFGVPAA PVLPFGLTPKKLYKPEVQLRRPNWS KLVAEDLSQDCFWTKVKEDRFENNE LFAKLTLTFSAQTKTSKAKKDQEGG EEKKSVQKKKVKELKVLDSKTAQNL SIFLGSFRMPYQEIKNVILEVNEAV LTESMIQNLIKQMPEPEQLKMLSEL KDEYDDLAESEQFGVVMGTVPRLRP RLNAILFKLQFSEQVENIKPEIVSV TAACEELRKSESFSNLLEITLLVGN YMNAGSRNAGAFGFNISFLCKLRDT KSTDQKMTLLHFLAELCENDYPDVL KFPDELAHVEKASRVSAENLQKNLD QMKKQISDVERDVQNFPAATDEKDK FVEKMTSFVKDAQEQYNKLRMMHSN METLYKELGEYFLFDPKKLSVEEFF MDLHNFRNMFLQAVKENQKRRETEE KMRRAKLAKEKAEKERLEKQQKREQ LIDMNAEGDETGVMDSLLEALQSGA AFRRKRGPRQANRKAGCAVTSLLAS ELTKDDAMAAVPAKVSKNSETFPTI LEEAKELVGRASTRTRPLEQKLISE EDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
