DPP6
-
Official Full Name
dipeptidyl-peptidase 6 -
Overview
This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] -
Synonyms
DPP6;dipeptidyl-peptidase 6;VF2;DPPX;dipeptidyl aminopeptidase-like protein 6;DPP VI;dipeptidylpeptidase 6;dipeptidyl peptidase VI;dipeptidyl peptidase IV-related protein;dipeptidyl aminopeptidase IV-related protein
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293T
- HEK293
- Yeast
- In Vitro Cell Free System
- His
- T7
- GST
- Flag
- Avi
- Fc
- DDK
- Myc
- Non
Involved Pathway
DPP6 involved in several pathways and played different roles in them. We selected most pathways DPP6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DPP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DPP6 has several biochemical functions, for example, NOT dipeptidyl-peptidase activity,potassium channel regulator activity,serine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DPP6 itself. We selected most functions DPP6 had, and list some proteins which have the same functions with DPP6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| potassium channel regulator activity | ADRB2,DRD4,KCNIP2,KCNMB2,AKAP9,SUMO1,PIAS3,SGK3,AMIGO1,CHP |
| serine-type peptidase activity | Reln,PREP,HTRA1B,TMPRSS13A,IMMP2L,HGFA,Gzmd,PRSS42,KLK1B22,C1RA |
| NOT dipeptidyl-peptidase activity | DPP10 |
Interacting Protein
DPP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPP6.
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