DPP9
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Official Full Name
dipeptidyl-peptidase 9 -
Overview
This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008] -
Synonyms
DPP9;dipeptidyl-peptidase 9;DP9;DPLP9;DPRP2;DPRP-2;dipeptidyl peptidase 9;DPP IX;dipeptidylpeptidase 9;dipeptidyl peptidase IX;dipeptidyl peptidase-like protein 9;dipeptidyl peptidase IV-related protein 2;dipeptidyl peptidase IV-related protein-2
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- Sf21 Cells
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
DPP9 involved in several pathways and played different roles in them. We selected most pathways DPP9 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DPP9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DPP9 has several biochemical functions, for example, aminopeptidase activity,identical protein binding,serine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DPP9 itself. We selected most functions DPP9 had, and list some proteins which have the same functions with DPP9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aminopeptidase activity | CTSH,METAP1D,PEPD,NPEPL1,CTSL2,XPNPEP1,ENPEP,Ctsl,LNPEP,NPEPPS |
| identical protein binding | ORAI1,CLDN8,FHOD1,PRPS2,COIL,CLDN16,FXR2,HSPB8,AHCY,RABAC1 |
| serine-type peptidase activity | TPP1,TMPRSS11F,TPSAB1,DPP6,PCSK5B,PRSS40,DPP7,PRSS42,PRSS59.2,PRSS59.1 |
Interacting Protein
DPP9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPP9 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPP9.
CSNK2A2;GRIA2;Bach1;Ppp2r1a;PARD6A
Resources
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References
- Harstad, EB; Rosenblum, JS; et al. DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley rat tissues. REGULATORY PEPTIDES 186:26-35(2013).
- Justa-Schuch, D; Moller, U; et al. The amino terminus extension in the long dipeptidyl peptidase 9 isoform contains a nuclear localization signal targeting the active peptidase to the nucleus. CELLULAR AND MOLECULAR LIFE SCIENCES 71:3611-3626(2014).
