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Official Full Name dual specificity phosphatase 5
Background The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily.These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus.
Synonyms DUSP5; dual specificity phosphatase 5; dual specificity protein phosphatase 5; HVH3; VH1-like phosphatase 3; dual specificity protein phosphatase hVH3; serine/threonine specific protein phosphatase; DUSP
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DUSP5-28378TH Recombinant Human DUSP5 Wheat Germ N/A
    Human DUSP5-2943H Recombinant Human DUSP5 Protein, GST-tagged Wheat Germ GST
    Human DUSP5-330H Recombinant Human DUSP5 Protein, His-tagged E.coli His
    Human DUSP5-382H Recombinant Human DUSP5 Protein, His-tagged E.coli His
    Human DUSP5-6772HCL Recombinant Human DUSP5 293 Cell Lysate HEK293 N/A
    Mouse Dusp5-383M Recombinant Mouse Dusp5 Protein, His-tagged E.coli His
    Rat DUSP5-1977R Recombinant Rat DUSP5 Protein Mammalian Cell His
    Zebrafish DUSP5-11845Z Recombinant Zebrafish DUSP5 Mammalian Cell His

    dusp5 involved in several pathways and played different roles in them. We selected most pathways dusp5 participated on our site, such as ARMS-mediated activation, ATF-2 transcription factor network, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with dusp5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ARMS-mediated activation CSK; SLC14A2; PEBP1; RASGRP4; PHB; FGF20A; NTF7; SPRED3; FRS3; PSME3
    ATF-2 transcription factor network POU2F1; CBFB; CDK4; KAT5; JUN; JUNB; CSRP2; JUND; JDP2; HRK
    Axon guidance ANK2B; RHOB; RHOD; SLIT3; GFRA2; KALRN; AP2B1; GPC1B; SEMA4A; RASA1
    Cytokine Signaling in Immune system EIF4E; TNIP2; IFIT11; GHRB; SPTA1; HERC5; JAK1; CSF2RB; OASL; KPNA3
    DAP12 interactions AHCYL1; FGF8B; DUSP6; CD300E; FRS2B; SPTB; THEM4; KIR2DS2; DUSP1; RASGRP4
    Developmental Biology SEMA4D; EFNB2; EFNB3B; BOC; SPTA1; SCN9A; CDON; PEA15A; ARPC5; SREBF2
    Direct p53 effectors GADD45A; EDN2; PCBP4; CEBPZ; PPM1J; CCNK; SMARCA4; TADA2B; CTSD; EPHA2

    dusp5 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, protein binding, protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by dusp5 itself. We selected most functions dusp5 had, and list some proteins which have the same functions with dusp5. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase tyrosine/serine/threonine phosphatase activity DUSP9; DUSP2; DUSP14; SACM1LA; DUSP18; TENC1; SACM1L; SACM1LB; DUSP6; DUSP5
    protein binding PHYHD1; GBP5; RAB5C; CCDC28A; KCNIP1; DROSHA; NPEPL1; TMEM19; MPG; PSMC2
    protein tyrosine phosphatase activity MTMR1A; PALD1; MTMR1; DUSP9; DUSP22B; DUSP10; DUSP18; RNGTT; LRP8; PTPRF
    protein tyrosine/serine/threonine phosphatase activity DUSP22; DUSP5; CDC14C; DUSP2; DUSP19B; NT5DC3; TENC1; DUSP21; DUSP4; DUSP9

    dusp5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with dusp5 here. Most of them are supplied by our site. Hope this information will be useful for your research of dusp5.


    Boeckx, C; de Beeck, KO; et al. Overcoming cetuximab resistance in HNSCC: The role of AURKB and DUSP proteins. CANCER LETTERS 354:365-377(2014).
    Moon, SJ; Lim, MA; et al. Dual-Specificity Phosphatase 5 Attenuates Autoimmune Arthritis in Mice via Reciprocal Regulation of the Th17/Treg Cell Balance and Inhibition of Osteoclastogenesis. ARTHRITIS & RHEUMATOLOGY 66:3083-3095(2014).

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