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Official Full Name eukaryotic translation elongation factor 1 epsilon 1
Background This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2.
Synonyms EEF1E1; eukaryotic translation elongation factor 1 epsilon 1; P18; eukaryotic translation elongation factor 1 epsilon-1; AIMP3; aminoacyl tRNA synthetase complex interacting multifunctional protein 3; AIMP 3; Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3; ARS interacting multifunctional protein 3; Cyclin dependent kinase 6 inhibitor; Elongation factor p18; Homolog of rat elongation factor p18; MCA3_HUMAN; Multisynthase complex auxiliary component p18; Multisynthetase complex auxiliary component p18; p18 component of aminoacyl tRNA synthetase complex; p18 INK4c; p18 NK6; ARS-interacting multifunctional protein 3; p18 component of aminoacyl-tRNA synthetase complex
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EEF1E1-12292H Recombinant Human EEF1E1, GST-tagged E.coli GST
    Human EEF1E1-131H Recombinant Human EEF1E1, His tagged E.coli His
    Human EEF1E1-27130TH Recombinant Human EEF1E1, His-tagged E.coli His
    Human EEF1E1-3073H Recombinant Human EEF1E1 Protein, GST-tagged Wheat Germ GST
    Human EEF1E1-3510H Recombinant Human EEF1E1 protein, His-tagged E.coli His
    Human EEF1E1-6713HCL Recombinant Human EEF1E1 293 Cell Lysate HEK293 N/A
    Mouse Eef1e1-1395M Recombinant Mouse Eef1e1 protein, His & T7-tagged E.coli His/T7
    Mouse EEF1E1-5002M Recombinant Mouse EEF1E1 Protein Mammalian Cell His
    Rhesus Macaque EEF1E1-1384R Recombinant Rhesus monkey EEF1E1 Protein, His-tagged Mammalian Cell His

    eef1e1 involved in several pathways and played different roles in them. We selected most pathways eef1e1 participated on our site, such as Cytosolic tRNA aminoacylation, Gene Expression, tRNA Aminoacylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with eef1e1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytosolic tRNA aminoacylation MADD; AARS; DARS; EEF1E1; AIMP2; AIMP1; KARS; FARSB
    Gene Expression SKI; C22orf28; D1BWG0212E; NR2C1; ZNF92; EIF2S1; EARS2; COX16; TYW3; HBXIP
    tRNA Aminoacylation FARSB; FARS2; EARS2; MADD; AIMP1; AARS; KARS; EEF1E1; AIMP2; WARS2

    eef1e1 has several biochemical functions, for example, glutathione transferase activity, protein binding, translation elongation factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by eef1e1 itself. We selected most functions eef1e1 had, and list some proteins which have the same functions with eef1e1. You can find most of the proteins on our site.

    Function Related Protein
    glutathione transferase activity GDAP1; GSTT1; GSTP1; GSTO2; GRX2; GSTM2; GSTZ1; GSTT4; EEF1E1; GSTT1B
    protein binding MYRIP; C22orf29; RNF5; KLF2; PALB2; CARD9; LDHAL6B; EFCAB4A; RAB22A; ARHGEF7
    translation elongation factor activity EEF1A2; EEF1E1; HBS1L; EEF1G; EEF1DA; EEF1A1A; EEF2; EEF2A.2; EIF5A; EEF1D

    eef1e1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with eef1e1 here. Most of them are supplied by our site. Hope this information will be useful for your research of eef1e1.

    NAT9; gag; CALCOCO2; EIF1B; ARF6; Dlgap4; ssrna_ug

    Kaiser, A; et al. Translational control of eIF5A in various diseases. AMINO ACIDS 42:679-684(2012).
    Park, JH; Dias, CAO; et al. Production of active recombinant eIF5A: reconstitution in E.coli of eukaryotic hypusine modification of eIF5A by its coexpression with modifying enzymes. PROTEIN ENGINEERING DESIGN & SELECTION 24:301-309(2011).

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