EFNA4
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Official Full Name
ephrin-A4
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Background
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified. -
Synonyms
EFNA4; ephrin-A4; EPLG4; LERK4; LERK-4; ligand of eph-related kinase 4; eph-related receptor tyrosine kinase ligand 4; EFL4; FLJ57652; MGC125826;
- Involved Pathway
- Protein Function
- Interacting Protein
- EFNA4 Related Research Area
EFNA4 involved in several pathways and played different roles in them. We selected most pathways EFNA4 participated on our site, such as Axon guidance, Developmental Biology, EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with EFNA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | ARHGEF28;EPHA7;SEMA3D;PLXNC1;RANBP9;MYL9;MYL12B;NRP1A;SEMA3A |
| Developmental Biology | EFNA4;EGR2;CEBPB;COL6A3;COL4A5;DUSP6;CD24;NADL1.1;EVL |
| EPH-Ephrin signaling | ARPC4;EPHA2A;EFNB1;EFNA5;EFNA2A;EPHB4A;CLTC;CFL1;ACTR2B |
| EPH-ephrin mediated repulsion of cells | EPHA10;EPHA4A;EFNB1;EPHA2A;EFNA3B;AP2A2;EFNA1A;EFNB2A;EFNA1 |
| EPHA-mediated growth cone collapse | EFNA3B;KDR;EFNA1A;MYL9;EFNA2;EPHA2;EFNA1;EFNA4;SHB |
| PI3K-Akt signaling pathway | CSF1;CSH1;CSH;CSH2;CSF3R;PRP2;CSF1R;CHAD;LOC608458 |
| Rap1 signaling pathway | LOC608458;CSF1;EFNA2;PFN4;RGS14;EFNA4 |
| Ras signaling pathway | RAP1B;PLA2G6;TEK;GNGT1;VEGFC;PLA2G12A;GRIN2A;PLA2G4A;PAK2 |
EFNA4 has several biochemical functions, for example, ephrin receptor binding, protein binding, transmembrane-ephrin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EFNA4 itself. We selected most functions EFNA4 had, and list some proteins which have the same functions with EFNA4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ephrin receptor binding | PTPN1;EFNA3B;EFNA2;EFNA5B;SDCBP;CBL;EFNA1;SIPA1L1;EPHA7 |
| protein binding | SDPR;FAM9B;CACNG2;MEF2C;IRS4;USF2;MRAS;SEPT3;LDB3 |
| transmembrane-ephrin receptor activity | EPHA10;EPHB1;EFNA4;EPHB2;EFNA3;EFNB3;EPHA4;EPHA1;EPHA5 |
EFNA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EFNA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of EFNA4.
EPHA7
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