• Official Full Name


  • Overview

    This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified.
  • Synonyms

    EFNA4; ephrin-A4; EPLG4; LERK4; LERK-4; ligand of eph-related kinase 4; eph-related receptor tyrosine kinase ligand 4; EFL4; FLJ57652; MGC125826;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Human Cell
  • Mammalian cells
  • C
  • Fc
  • hFc
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • human|IgG1|Fc
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EFNA4-177H Recombinant Human EFNA4 protein, Fc-tagged HEK293 human/IgG1/Fc Leu26-Gly171
Human EFNA4-1610H Recombinant Human Ephrin-A4 Mammalian cells N/A
Human EFNA4-151H Recombinant Human Ephrin-A4 E.coli N/A
Human EFNA4-4336H Recombinant Human Ephrin-A4, GST-Tagged Human GST
Human EFNA4-001HCL Recombinant Human EFNA4 cell lysate Human Cell N/A
Human EFNA4-3461H Recombinant Human EFNA4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human EFNA4-323H Active Recombinant Human EFNA4 protein, His-tagged HEK293 His Met1-Gly171
Human EFNA4-1380H Recombinant Human EFNA4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human EFNA4-4396H Recombinant Human EFNA4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human EFNA4-1408H Active Recombinant Human EFNA4 protein, Fc-tagged HEK293 Fc Leu26-Gly171
Human EFNA4-232H Recombinant Human EFNA4 Protein, His-tagged HEK293 His 201
Human EFNA4-233H Recombinant Human EFNA4 Protein, Fc-tagged HEK293 Fc 201
Human EFNA4-2667H Active Recombinant Human EFNA4 protein, hFc&His-tagged HEK293 hFc&His Leu26-Gly171
Human EFNA4-4396H-B Recombinant Human EFNA4 Protein Pre-coupled Magnetic Beads HEK293
Mouse Efna4-440M Active Recombinant Mouse Ephrin A4 Mammalian cells N/A
Mouse Efna4-4057M Active Recombinant Mouse Efna4 protein, His-tagged HEK293 His Met1-Gly176
Mouse Efna4-4056M Recombinant Mouse Efna4 protein(Met1-Gly176), hFc-tagged HEK293 C-hFc Met1-Gly176
Mouse Efna4-1130M Recombinant Mouse Efna4 protein, His & GST-tagged E.coli His/GST Met1~Leu206 (Accession # O08542)
Mouse EFNA4-2158MCL Recombinant Mouse EFNA4 cell lysate Human Cell N/A
Mouse Efna4-10538M-B Recombinant Mouse Efna4 Protein Pre-coupled Magnetic Beads HEK293
Mouse Efna4-10538M Recombinant Mouse Efna4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Efna4-5644M Recombinant Mouse Efna4 Protein (Arg27-Gly176), C-Fc tagged Mammalian cells C-Fc Arg27-Gly176
Mouse Efna4-050M Recombinant Mouse Efna4 Protein, Fc-tagged HEK293 Fc
Mouse Efna4-051M Recombinant Mouse Efna4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Efna4-1131R Recombinant Rat Efna4 protein, His & T7-tagged E.coli His/T7 Met1~Leu204 (Accession # D3ZEN1)
Rat Efna4-1132R Recombinant Rat Efna4 protein, His & GST-tagged E.coli His/GST Met1~Leu204 (Accession # D3ZEN1)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

EFNA4 involved in several pathways and played different roles in them. We selected most pathways EFNA4 participated on our site, such as Axon guidance, Developmental Biology, EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with EFNA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
EPH-ephrin mediated repulsion of cellsEFNA3;EFNB2A;EFNA1B;CLTB;EFNA2;EPHB3A;EFNA2A;EFNB1;EFNA5
EPHA-mediated growth cone collapseEFNA3;EFNA5;SHB;EPHA10;EPHA4A;EFNA3B;KDR;EFNA4;MYL12B
PI3K-Akt signaling pathwayCSF1R;SGK2;CSF3R;EFNA4;PIK3AP1;CSH;EFNA3;CSF1;CDC37
Rap1 signaling pathwayEFNA2;EFNA4;RGS14;LOC608458;PFN4;CSF1
Ras signaling pathwayPDGFB;GAB1;FLT4;ETS2;FGF12;FGF22;PIK3CD;LAT;RRAS2

EFNA4 has several biochemical functions, for example, ephrin receptor binding, protein binding, transmembrane-ephrin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EFNA4 itself. We selected most functions EFNA4 had, and list some proteins which have the same functions with EFNA4. You can find most of the proteins on our site.

Function Related Protein
ephrin receptor bindingEFNB3B;ANKS1B;EFNA2;PTPN1;CDK5;PIK3CG;SIPA1L1;EFNA3B;EFNA5B
transmembrane-ephrin receptor activityEFNA3;EPHB1;EPHA10;EPHA5;EFNB3;EPHA1;EFNA4;EPHB2;EPHA4

EFNA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EFNA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of EFNA4.


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