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Official Full Name eukaryotic translation initiation factor 4E
Background Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.
Synonyms EIF4E; eukaryotic translation initiation factor 4E; CBP; EIF4F; EIF4E1; EIF4EL1; MGC111573; eIF-4E; OTTHUMP00000219701; OTTHUMP00000219702; OTTHUMP00000219703; OTTHUMP00000219704; OTTHUMP00000219705; eIF-4F 25 kDa subunit; mRNA cap-binding protein; eukaryotic translation initiation factor 4E-like 1
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EIF4E-2050H Recombinant Human EIF4E protein E.coli N/A
    Human EIF4E-2373H Recombinant Human Eukaryotic Translation Initiation Factor 4E, GST-tagged E.coli GST
    Human EIF4E-2775H Recombinant Human EIF4E, His-tagged E.coli His
    Human EIF4E-2922H Recombinant Human EIF4E Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human EIF4E-3198H Recombinant Human EIF4E Protein, GST-tagged Wheat Germ GST
    Human EIF4E-6651HCL Recombinant Human EIF4E 293 Cell Lysate HEK293 N/A
    Mouse EIF4E-5106M Recombinant Mouse EIF4E Protein Mammalian Cell His
    Mouse Eif4e-5107M Recombinant Mouse Eif4e Protein, His-tagged E.coli His
    Mouse Eif4e-811M Recombinant Mouse Eif4e Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat EIF4E-2066R Recombinant Rat EIF4E Protein Mammalian Cell His
    Rhesus Macaque EIF4E-1428R Recombinant Rhesus monkey EIF4E Protein, His-tagged Mammalian Cell His

    eif4e involved in several pathways and played different roles in them. We selected most pathways eif4e participated on our site, such as Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Alpha6-Beta4 Integrin Signaling Pathway, Antiviral mechanism by IFN-stimulated genes, which may be useful for your reference. Also, other proteins which involved in the same pathway with eif4e were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S FAUB; EIF3K; EIF2S3; EIF4B; EIF1AXA; EIF2S1A; EIF4A1; EIF4E; EIF4H; EIF4G1
    Alpha6-Beta4 Integrin Signaling Pathway CD151L; PLEC; EIF4E; RTKN; CD151; DSP; EGFR; EIF4EB; EIF4EBP1; SMAD3B
    Antiviral mechanism by IFN-stimulated genes EIF4G2; IFIT12; EIF4G2A; MX2; EIF4A2; DPF1; NUP35; KPNA5; KPNA4; KPNA3
    BDNF signaling pathway CDK5; CDKL5; CNR1; EIF2S1; CSNK2A1; EIF4EBP1; CDH2; DOK5; SIRPA; JAK2
    Cap-dependent Translation Initiation EIF4B; FAUB; EIF4A1; EIF2S1; EIF4A2; EIF3K; EIF4G1; EIF4EB; EIF5; RPL35
    Cytokine Signaling in Immune system NOD1; EIF4E; IRF2; XAF1; BST2; PHB; PEBP1; TNIP2; IL1RN; IRAK3
    Deadenylation of mRNA C2orf29; EIF4G1; EIF4B; EIF4A2; PAIP1; TNKS1BP1; EIF4E; EIF4A1; EIF4EB; D1BWG0212E
    Deadenylation-dependent mRNA decay EIF4A1; EIF4A2; LSM6; TNKS1BP1; D1BWG0212E; EIF4G1; PAIP1; EIF4B; NT5C3B; EIF4E

    eif4e has several biochemical functions, for example, RNA cap binding, enzyme binding, eukaryotic initiation factor 4G binding. Some of the functions are cooperated with other proteins, some of the functions could acted by eif4e itself. We selected most functions eif4e had, and list some proteins which have the same functions with eif4e. You can find most of the proteins on our site.

    Function Related Protein
    RNA cap binding EIF4A1; NCBP1; LARP1; EIF4E; NCBP2; EIF4E2; EIF4G3; SNUPN
    enzyme binding NOTCH1; TTN; TSPAN10; BCR; HSPA2; CD40; UGT1A7; HDAC1; MST1R; KIAA1967
    eukaryotic initiation factor 4G binding EIF4E
    poly(A) RNA binding SCG3; RPSA; GSPT2; NSBP1; NCBP2; DHX34; CPSF6; IFIT2; DHX33; CASC3
    protein binding USP47; Il4ra; MRPL1; SORCS1; IL24; HSPD1; SPTBN1; CUTC; WWC1; TCF3
    repressing transcription factor binding CTBP1; ARNTL; CTNNB1; HDAC5; RELA; NOC2L; HDAC7A; PARK7; HDAC9; TBP
    translation initiation factor activity EIF1; EIF4H; EIF2S3Y; DHX29; COPS5; EIF3JB; EIF3EA; EIF2S3; EIF4E2RS1; EIF2D

    eif4e has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with eif4e here. Most of them are supplied by our site. Hope this information will be useful for your research of eif4e.


    Moodley, V; Naidoo, R; et al. Screening of pepper (Capsicum annuum L.) lines for resistance to an isolate of Potato virus Y (PVY) occurring in KwaZulu-Natal (KZN), Republic of South Africa. CROP PROTECTION 68:36-40(2015).
    Osman, AM; van Loveren, H; et al. The immunosuppressant tributyltin oxide blocks the mTOR pathway, like rapamycin, albeit by a different mechanism. JOURNAL OF APPLIED TOXICOLOGY 34:1361-1367(2014).

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