EIF4G1
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Official Full Name
eukaryotic translation initiation factor 4 gamma, 1 -
Overview
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010] -
Synonyms
EIF4G1;eukaryotic translation initiation factor 4 gamma, 1;P220;EIF4F;EIF4G;EIF4GI;PARK18;EIF-4G1;eukaryotic translation initiation factor 4 gamma 1;EIF4-gamma;eIF-4-gamma 1;eucaryotic translation initiation factor 4G
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- HEK293
- Mammalian Cells
- Yeast
- In Vitro Cell Free System
- His
- GST
- DDK
- Myc
- Non
- Flag
- Twin Strep
- B2M
- Trx
- Avi
- Fc
Involved Pathway
EIF4G1 involved in several pathways and played different roles in them. We selected most pathways EIF4G1 participated on our site, such as AUF1 (hnRNP D0) binds and destabilizes mRNA,Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,Antiviral mechanism by IFN-stimulated genes, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4G1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cap-dependent Translation Initiation | EIF2S1A,EIF1AX,EIF2B1,EIF1AXA,EIF2S3,EIF3K,EIF4EB,FAUB,EIF4H,RPL35 |
| Eukaryotic Translation Initiation | EIF1AX,EIF2S1A,EIF1AXA,EIF2S3,EIF3K,EIF4B,EIF4A1,EIF5,EIF4H,EIF4A2 |
| Deadenylation of mRNA | EIF4B,EIF4A1,PAIP1,EIF4E,EIF4EB,TNKS1BP1,D1BWG0212E,EIF4A2,C2orf29 |
| Antiviral mechanism by IFN-stimulated genes | EIF4E,NUPL2,IFIT11,EIF4EB,MX2,NUP50,ARIH1,JAK1,IFIT10,EIF4G2A |
| Deadenylation-dependent mRNA decay | PAIP1,LSM6,DCP1B,EIF4E,DDX6,EIF4B,NT5C3B,EIF4A2,EIF4A1,EIF4EB |
| Cytokine Signaling in Immune system | SAMHD1,TRIM2,GBP5,DAB2IPB,KLB,CSH1,CRK,PELI3,PTPRA,FGF20A |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | PSMD9,PSMD10,PSME3,PSMD14,HNRNPD,PSMD5,PSMA8 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | EIF1AXA,EIF1AX,EIF2S1,EIF2S1A,EIF4E,EIF2S3,FAUB,EIF4A2,EIF3K,EIF4H |
Protein Function
EIF4G1 has several biochemical functions, for example, eukaryotic initiation factor 4E binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4G1 itself. We selected most functions EIF4G1 had, and list some proteins which have the same functions with EIF4G1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | GATA6,KPNA1,GFM1,SH2B1,HSPA14,RAB9B,ZNF131,HMOX2,RBPMS2B,CDK5R2 |
| translation factor activity, RNA binding | CPEB4,EIF1AX,EIF1,SOX11,GTF2H2,PPP1R2P9,CPEB1A,EIF2S2,EIF2S3,EIF4H |
| eukaryotic initiation factor 4E binding | OTX2,GRA,EIF4EBP2,EIF4EBP3,ANGEL1,EIF4EBP1,LARP1,DDX3X,EIF4EBP3L,HHEX |
| poly(A) RNA binding | FAM103A1,ATP5A1,STAU2,CDC42EP4,FSCN1,DEK,RBM3,REXO4,HIST1H47,FLNA |
| translation initiation factor activity | MCTS1,EIF4BB,GTPBP1,EIF2S1,DENR,BRF1A,EIF4A1A,EIF2S3,EIF4G2,EIF2S1B |
Interacting Protein
EIF4G1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4G1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4G1.
EIF4A1;PABPC1;EIF4A2;EIF4E
EIF4G1 Related Signal Pathway
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