EIF4G1

  • Official Full Name

    eukaryotic translation initiation factor 4 gamma, 1
  • Overview

    The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
  • Synonyms

    EIF4G1;eukaryotic translation initiation factor 4 gamma, 1;P220;EIF4F;EIF4G;EIF4GI;PARK18;EIF-4G1;eukaryotic translation initiation factor 4 gamma 1;EIF4-gamma;eIF-4-gamma 1;eucaryotic translation initiation factor 4G

Recombinant Proteins

  • Human
  • Mouse
  • E.coli
  • Wheat Germ
  • HEK293
  • Mammalian Cells
  • Yeast
  • In Vitro Cell Free System
  • His
  • GST
  • DDK
  • Myc
  • Non
  • Flag
  • B2M
  • Trx
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
EIF4G1-12383H Recombinant Human EIF4G1 protein, His-tagged E.coli Human His 296-645 aa
EIF4G1-28550TH Recombinant Human EIF4G1, GST-tagged Wheat Germ Human GST
EIF4G1-01H Active Recombinant Human EIF4G1 protein, Myc/DDK-tagged HEK293 Human DDK&Myc
EIF4G1-479H Recombinant Human EIF4G1 Mammalian Cells Human His
EIF4G1-545HCL Recombinant Human EIF4G1 cell lysate Human Non
EIF4G1-02H Recombinant Human EIF4G1 protein, Myc/DDK-tagged HEK293 Human DDK&Myc
EIF4G1-1009HFL Recombinant Full Length Human EIF4G1 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
EIF4G1-12384H Recombinant Human EIF4G1 protein, GST-tagged E.coli Human GST 296-645 aa
EIF4G1-1387H Recombinant Human EIF4G1 Protein (1250-1599 aa), His-tagged Yeast Human His 1250-1599 aa
EIF4G1-151HF Recombinant Full Length Human EIF4G1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 1500 a.a. - 1599 a.a.
Eif4g1-2789M Recombinant Mouse Eif4g1 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
EIF4G1-2825H Recombinant Human EIF4G1 protein(1061-1180 aa), C-His-tagged E.coli Human His 1061-1180 aa
EIF4G1-2844H Recombinant Human EIF4G1 protein, His-B2M-JD & Myc-tagged E.coli Human B2M&His&Myc 1250-1599aa
EIF4G1-2887H Recombinant Human EIF4G1 Protein (Glu557-Lys646), N-His and Trx tagged E.coli Human His&Trx Glu557-Lys646
EIF4G1-477H Recombinant Human EIF4G1 Protein (1250-1599 aa), GST-tagged E.coli Human GST 1250-1599 aa
EIF4G1-5398H Recombinant Human EIF4G1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
EIF4G1-830H Recombinant Human EIF4G1 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
EIF4G1-830H-B Recombinant Human EIF4G1 Protein Pre-coupled Magnetic Beads HEK293 Human

    Involved Pathway

    EIF4G1 involved in several pathways and played different roles in them. We selected most pathways EIF4G1 participated on our site, such as AUF1 (hnRNP D0) binds and destabilizes mRNA,Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,Antiviral mechanism by IFN-stimulated genes, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4G1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Eukaryotic Translation Initiation FAUB,EIF3K,EIF5,EIF2S3,EIF2S1A,EIF1AX,EIF4A2,EIF4B,EIF4A1,EIF4EB
    Deadenylation of mRNA PAIP1,EIF4B,EIF4A2,TNKS1BP1,EIF4EB,D1BWG0212E,EIF4E,EIF4A1,C2orf29
    Cytokine Signaling in Immune system TRIM2,IFI30,NRG3,EIF4A2,SPTBN2,NUP50,IFIT3,TRIM22,IFIT2,TRIM31
    Cap-dependent Translation Initiation EIF4H,EIF4E,EIF2B1,EIF4A1,EIF4EBP1,EIF5,EIF4A2,EIF2S1,EIF3K,EIF1AXA
    Antiviral mechanism by IFN-stimulated genes JAK1,ARIH1,KPNA3,HERC5,MX2,EIF4G2,EIF4E3,EIF4A2,IFIT14,ARIH1L
    Deadenylation-dependent mRNA decay EIF4A1,DDX6,EIF4A2,DCP2,PAIP1,LSM6,DCP1B,NT5C3B,D1BWG0212E,C2orf29
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S FAUB,EIF4A2,EIF4EBP1,EIF4H,EIF2S1A,EIF4B,EIF3K,EIF1AXA,EIF2S3,EIF4E
    AUF1 (hnRNP D0) binds and destabilizes mRNA PSMD9,PSMD14,PSMD5,PSMD10,PSME3,PSMA8,HNRNPD

    Protein Function

    EIF4G1 has several biochemical functions, for example, eukaryotic initiation factor 4E binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4G1 itself. We selected most functions EIF4G1 had, and list some proteins which have the same functions with EIF4G1. You can find most of the proteins on our site.

    Function Related Protein
    translation initiation factor activity EIF2S1A,EIF3HB,MTIF2,EIF1AY,GTPBP2,EIF2S3Y,EIF3HA,EIF2D,EIF2S1,EIF3S10
    poly(A) RNA binding EMG1,MAZ,MRPL44,CAPRIN1,DDX49,ZNF622,RBMS1,HNRNPDL,PPIG,IFIT2
    eukaryotic initiation factor 4E binding EIF4EBP2,GRA,HHEX,LARP1,DDX3X,ANGEL1,EIF4EBP3L,EIF4EBP3,EIF4EBP1,OTX2
    protein binding GRIP1,RTN4A,XRCC1,FRAS1,CUTA,GNB1B,FAM156A,SLX1B,SETMAR,FGF19
    translation factor activity, RNA binding CPEB1B,EIF4H,EEF2K,CPEB2,EIF5,EIF4A1,EIF2S3,EEF1A2,EIF1,CPEB4

    Interacting Protein

    EIF4G1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4G1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4G1.

    EIF4A1;PABPC1;EIF4A2;EIF4E

    EIF4G1 Related Signal Pathway

    Resources

    References

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