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Official Full Name eukaryotic translation initiation factor 4 gamma, 1
Background The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
Synonyms EIF4G1; eukaryotic translation initiation factor 4 gamma, 1; P220; EIF4F; EIF4G; EIF4GI; PARK18; EIF-4G1; eukaryotic translation initiation factor 4 gamma 1; EIF4-gamma; eIF-4-gamma 1; eucaryotic translation initiation factor 4G;
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EIF4G1-12383H Recombinant Human EIF4G1, His-tagged E.coli His
    Human EIF4G1-1387H Recombinant Human EIF4G1 Protein (1250-1599 aa), His-tagged Yeast His
    Human EIF4G1-28550TH Recombinant Human EIF4G1, GST-tagged Wheat Germ GST
    Human EIF4G1-477H Recombinant Human EIF4G1 Protein (1250-1599 aa), GST-tagged E.coli GST
    Human EIF4G1-479H Recombinant Human EIF4G1 Mammalian Cell His
    Human EIF4G1-5398H Recombinant Human EIF4G1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human EIF4G1-545HCL Recombinant Human EIF4G1 cell lysate N/A
    Mouse Eif4g1-2789M Recombinant Mouse Eif4g1 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    eif4g1 involved in several pathways and played different roles in them. We selected most pathways eif4g1 participated on our site, such as AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Antiviral mechanism by IFN-stimulated genes, which may be useful for your reference. Also, other proteins which involved in the same pathway with eif4g1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    AUF1 (hnRNP D0) binds and destabilizes mRNA PSMD14; HNRNPD; PSMD10; PSMA8; PSME3; PSMD5; PSMD9; EIF4G1
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S EIF4A1; EIF4E; EIF2S1A; EIF4EBP1; EIF2S3; EIF4G1; EIF1AXA; EIF2S1; EIF4EB; EIF3K
    Antiviral mechanism by IFN-stimulated genes NUP35; EIF4A2; ARIH1; IFIT11; EIF4G2A; IFIT10; EIF4E3; EIF4E; JAK1; ARIH1L
    Cap-dependent Translation Initiation EIF2S1A; RPL35; EIF2S1; FAUB; EIF4H; EIF4G1; EIF1AXA; EIF2B1; EIF4E; EIF3K
    Cytokine Signaling in Immune system DPF1; EIF4E; FGFR1B; TRIM26; KLB; FGF10B; EIF4E3; FRS3; MAP3K8; TRIM10
    Deadenylation of mRNA EIF4B; TNKS1BP1; EIF4A2; EIF4A1; C2orf29; EIF4G1; EIF4EB; D1BWG0212E; EIF4E; PAIP1
    Deadenylation-dependent mRNA decay DCP2; EIF4G1; EXOSC8; DCP1B; NT5C3B; PAIP1; D1BWG0212E; EIF4E; EIF4A2; EIF4B
    Eukaryotic Translation Initiation EIF4H; FAUB; EIF4A1; EIF2S1; EIF2B1; EIF4EB; EIF4B; EIF4G1; EIF1AX; EIF5

    eif4g1 has several biochemical functions, for example, eukaryotic initiation factor 4E binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by eif4g1 itself. We selected most functions eif4g1 had, and list some proteins which have the same functions with eif4g1. You can find most of the proteins on our site.

    Function Related Protein
    eukaryotic initiation factor 4E binding HHEX; GRA; ANGEL1; EIF4G1; EIF4EBP3L; EIF4EBP2; EIF4EBP3; DDX3X; EIF4EBP1; LARP1
    poly(A) RNA binding C3orf26; CLK3; NKRF; RBM47; MRPL27; RPL7L1; RRP8; NUCKS1; DDX39A; SUGP1
    protein binding CATSPERG2; PLSCR1; TSSK3; KIF13B; CDC42EP1; CHTOP; PLEKHO1; Ctsl; HTT; KRT40
    translation factor activity, RNA binding CPEB2; EIF4G1; EEF1D; EEF2K; EIF4A1; EEF1A2; PPP1R2P9; CPEB4; EIF4H; CPEB1A
    translation initiation factor activity EIF2S3; EIF2S2; EIF3BA; EIF4EA; EIF5B; EIF4BB; EIF4E1C; EIF2B5; EIF3B; EIF4EB

    eif4g1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with eif4g1 here. Most of them are supplied by our site. Hope this information will be useful for your research of eif4g1.


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