ELK1
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Official Full Name
ELK1 ELK1, member of ETS oncogene family -
Synonyms
ELK1;ELK1, member of ETS oncogene family;ETS domain-containing protein Elk-1;ETS-like gene 1;tyrosine kinase (ELK1) oncogene
Recombinant Proteins
- Rhesus macaque
- Human
- Cynomolgus
- Mouse
- Mammalian Cells
- E.coli
- Wheat Germ
- Insect Cells
- HEK293
- Sf9 Cells
- His
- Myc
- GST
- Non
- Avi
- Fc
Involved Pathway
ELK1 involved in several pathways and played different roles in them. We selected most pathways ELK1 participated on our site, such as MAPK signaling pathway,ErbB signaling pathway,Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ELK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Prion diseases | MAPK3,C8A,STIP1,IL1A,C5,PRKACB,MAP2K1,NOTCH1,NCAM2,FYN |
| Proteoglycans in cancer | NANOG,LUM,WNT8A,FGFR1,EZR,ERBB4,CTTN,WNT9B,PIK3R2,MAP2K2 |
| MAPK signaling pathway | FGF1A,RPS6KA5,CACNA2D4,TGFBR1A,Pdgfa&Pdgfb,RPS6KA2,KCNA3,TGFBR2,PPM1BA,FGF6A |
| Ras signaling pathway | CALM3,FGFR2,PLA2G12B,PAK6,FGF17,GNG12,PLA2G2E,RASSF1,ARF6,RAB5C |
| Focal adhesion | ITGB5,RAC2,HRAS,COL11A1A,RHOAC,LAMA2,LAMB3,RAP1A,COL5A2,ITGA1 |
| Oxytocin signaling pathway | CACNG6,PRKAB1,CACNB3,PRKAA2,CAMK2B,PLA2G4C,MYLK,NFATC2,CACNA2D3,MYLK2 |
| GnRH signaling pathway | PLA2G4C,GNA15.1,PLA2G4D,PRKCBA,PLA2G4AA,GNRH2,RAF1,CALM4,MAPK12,ATF4 |
| ErbB signaling pathway | PTK2AB,GRB2,PIK3R5,SHC4,CAMK2D2,MAP2K2,PIK3R2,TGFA,PIK3CA,AKT2L |
| Endometrial cancer | FOXO3,PTEN,BRAF,PIK3CB,CTNNA2,BAD,PIK3R5,TRP53,HRAS,PIK3CD |
Protein Function
ELK1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding,core promoter binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ELK1 itself. We selected most functions ELK1 had, and list some proteins which have the same functions with ELK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | PBX1,CTCF,LHX1,NR1D2B,GTF2H3,ESR1,HSFY1,ZNF789,MYCB,PTF1A |
| protein binding | NDUFA13,EN1,ING5,BBS7,MYO5A,LBR,MBD3,TNFSF12,FRMD8,STON2 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | SOX1,RBPJB,ZIC3,RFX1A,KLF5,ZFP536,NFATC4,JUNBA,ARID3B,NR1D1 |
| chromatin binding | TDRD3,PRDM13,SKOR2,TRP63,FANCM,POLE,SP140,HINFP,POU5F3,LDB1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | SRF,MAFA,MEF2B,STAT3,NFIC,PBX1,ZFP750,GABPA,NR4A2,NKX2-5 |
| core promoter binding | CRY1,XBP1,NKX2-1,NEUROG3,SFPI1,EP300,NOTCH1,CLOCK,HDAC6,E2F1 |
Interacting Protein
ELK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ELK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ELK1.
UBE2I;SUMO1;MAPK3;psen1_human_dna_probe;PLCG2;CRK
ELK1 Related Signal Pathway
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References
- Legrand, N; Araud, T; et al. An AUG Codon Conserved for Protein Function Rather than Translational Initiation: The Story of the Protein sElk1. PLOS ONE 9:-(2014).
- Hennenberg, M; Strittmatter, F; et al. Silodosin Inhibits Noradrenaline-Activated Transcription Factors Elk1 and SRF in Human Prostate Smooth Muscle. PLOS ONE 7:-(2012).
