Recombinant Human ELK1, Member Of ETS Oncogene Family, GST-tagged

• Cat.No.: ELK1-4841H
• Product Overview: Recombinant full-length human ELK1 was expressed in E. coli cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Description: ELK1 is a member of the ETS oncogene family of transcription factors. ELK1 protein interacts with promoter of the c-fos proto-oncogene and has been shown to be involved in the Ras-Raf-MAPK signaling cascade. Immature phosphorylation of transcription factor ELK-1 is implicated in premature aging syndrome and insulin resistance. Expression studies have revealed that elevated expression of ELK1-like protein in human esophageal can result in squamous cell carcinoma.
• Applications: Kinase Assay; Western Blot
• Molecular Weight: 81 kDa
• Expression System: E. coli
• Form: Recombinant protein stored in 50 mM Tris-HCl, ph 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.
• Purity: > 75 %
• Concentration: 0.2 ug/ul
• Sequences: Full length
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: Activated TLR4 signalling; BCR signaling pathway; EGFR1 Signaling Pathway; ERK/MAPK targets; Endometrial cancer; ErbB signaling pathway; ErbB signaling pathway; ErbB signaling pathway; Focal Adhesion; GnRH signaling pathway; HTLV-I infection; IL-4 signaling Pathway; IL-5 Signaling Pathway; Id Signaling Pathway; Insulin Signaling

Gene Information

• Gene Name: ELK1 ELK1, member of ETS oncogene family [ Homo sapiens ]
• Official Symbol: ELK1
• Synonyms: ELK1; ELK1, member of ETS oncogene family; ETS domain-containing protein Elk-1; ETS-like gene 1; OTTHUMP00000023224; OTTHUMP00000023225
• Gene ID: 2002
• mRNA Refseq: NM_005229
• Protein Refseq: NP_005220
• MIM: 311040
• UniProt ID: P19419
• Chromosome Location: Xp11.2
• Function: protein binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity