Recombinant Human ERCC3

• Cat.No.: ERCC3-30702TH
• Product Overview: Recombinant full length Human XPB with a N terminal proprietary tag; predicted MW: 112.09 kDa inclusive of tag. P19447,

Specification

• Species: Human
• Source: Wheat Germ
• Tag: Non
• Protein Length: 782 amino acids
• Description: ERCC3 is an ATP-dependent DNA helicase that functions in nucleotide excision repair and complements xeroderma pigmentosum group B mutations. It also is the 89 kDa subunit of basal transcription factor 2 (TFIIH) and thus functions in class II transcription.
• Molecular Weight: 112.090kDa inclusive of tags
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MGKRDRADRDKKKSRKRHYEDEEDDEEDAPGNDPQEAVPS AAGKQVDESGTKVDEYGAKDYRLQMPLKDDHTSRPLWVAP DGHIFLEAFSPVYKYAQDFLVAIAEPVCRPTHVHEYKLTA YSLYAAVSVGLQTSDITEYLRKLSKTGVPDGIMQFIKLCT VSYGKVKLVLKHNRYFVESCHPDVIQHLLQDPVIRECRLR NSEGEATELITETFTSKSAISKTAESSGGPSTSRVTDPQG KSDIPMDLFDFYEQMDKDEEEEEETQTVSFEVKQEMIEEL QKRCIHLEYPLLAEYDFRNDSVNPDINIDLKPTAVLRPYQ EKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKR CLVLGNSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKP IGCSVAISTYSMLGHTTKRSWEAERVMEWLKTQEWGLMIL DEVHTIPAKMFRRVLTIVQAHCKLGLTATLVREDDKIVDL NFLIGPKLYEANWMELQNNGYIAKVQCAEVWCPMSPEFYR EYVAIKTKKRILLYTMNPNKFRACQFLIKFHERRNDKIIV FADNVFALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNP KINTIFISKVGDTSFDLPEANVLIQISSHGGSRRQEAQRL GRVLRAKKGMVAEEYNAFFYSLVSQDTQEMAYSTKRQRFL VDQGYSFKVITKLAGMEEEDLAFSTKEEQQQLLQKVLAAT DLDAEEEVVAGEFGSRSSQASRRFGTMSSMSGADDTVYME YHSSRSKAPSKHVHPLFKRFRK
• Sequence Similarities: Belongs to the helicase family. RAD25/XPB subfamily.Contains 1 helicase ATP-binding domain.Contains 1 helicase C-terminal domain.

Gene Information

• Gene Name: ERCC3 excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) [ Homo sapiens ]
• Official Symbol: ERCC3
• Synonyms: ERCC3; excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing); TFIIH basal transcription factor complex helicase XPB subunit; BTF2; GTF2H; RAD25; TFIIH; XPB
• Gene ID: 2071
• mRNA Refseq: NM_000122
• Protein Refseq: NP_000113
• MIM: 133510
• Uniprot ID: P19447
• Chromosome Location: 2q21
• Pathway: Basal transcription factors, organism-specific biosystem; Basal transcription factors, conserved biosystem; DNA Repair, organism-specific biosystem; Dual incision reaction in GG-NER, organism-specific biosystem; Dual incision reaction in TC-NER, organism-specific biosystem
• Function: 3-5 DNA helicase activity; 3-5 DNA helicase activity; ATP binding; ATP-dependent DNA helicase activity; ATPase activity