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FADD

  • Official Full Name

    Fas (TNFRSF6)-associated via death domain

  • Overview

    The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
  • Synonyms

    FADD; Fas (TNFRSF6)-associated via death domain; GIG3; MORT1; FAS-associated death domain protein; growth-inhibiting gene 3 protein; mediator of receptor induced toxicity; mediator of receptor-induced toxicity; Fas-associating protein with death domain; Fas-associating death domain-containing protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • E.coli
  • Escherichia coli (strain K12)
  • Human
  • Mouse
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FADD-4351H Recombinant Human Fas (TNFRSF6)-associated via death domain, His-tagged Human His
Human FADD-3640H Recombinant Human FADD Protein, GST-tagged Wheat Germ GST
Human FADD-28819TH Recombinant Human FADD E.coli N/A
Human FADD-28817TH Recombinant Human FADD, His-tagged E.coli His
Human FADD-381H Recombinant Human Fas (TNFRSF6)-associated Via Death Domain, GST tagged E.coli GST
Human FADD-6473HCL Recombinant Human FADD 293 Cell Lysate HEK293 N/A
Human FADD-885H-B Recombinant Human FADD Protein Pre-coupled Magnetic Beads HEK293
Human FADD-382H Recombinant Human FADD protein, GST-tagged E. coli GST 1-208 aa
Human FADD-1644HFL Recombinant Full Length Human FADD Protein, C-Flag-tagged Mammalian cells Flag
Human FADD-805H Recombinant Human FADD Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FADD-4435HF Recombinant Full Length Human FADD Protein, GST-tagged In Vitro Cell Free System GST 208 amino acids
Human FADD-885H Recombinant Human FADD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human FADD-3217H Recombinant Human FADD Protein (Ser12-Glu206), N-His tagged E.coli N-His Ser12-Glu206
Mouse FADD-5430M Recombinant Mouse FADD Protein Mammalian Cell His
Mouse FADD-2932M-B Recombinant Mouse FADD Protein Pre-coupled Magnetic Beads HEK293
Mouse Fadd-1743M Recombinant Mouse Fadd protein, His & T7-tagged E.coli His/T7 Leu7~Glu178 (Accession # Q61160)
Mouse FADD-2932M Recombinant Mouse FADD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Fadd-1012M Recombinant Mouse Fadd Protein, MYC/DDK-tagged HEK293T MYC/DDK
E.coli FADD-2352E Recombinant Escherichia coli FADD Protein (1-561 aa), His-tagged E.coli His 1-561 aa
Escherichia coli (strain K12) fadD-3693E Recombinant Escherichia coli (strain K12) fadD protein, His-tagged E.coli His 1-561aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FADD Related Articles
  • FADD Related Research Area

FADD involved in several pathways and played different roles in them. We selected most pathways FADD participated on our site, such as Apoptosis, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FADD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ApoptosisIL1RAP;GZMF;IRAK4;PIK3CG;CAPN1B;IRF2A;ENDOG;TP53;CASP3B
Toll-like receptor signaling pathwayRAC1A;TLR9;IFNB;PIK3R3B;IRF5;PIK3CG;CD86;IRF3;PIK3CA
RIG-I-like receptor signaling pathwayMAPK14A;TRADD;IFNA4;IL12A;IL8L2;IL-8;RNF125;IRF7;MAVS
TNF signaling pathwayFAS;TRAF3;MAGI2;CXCL1;PTGS2;MAPK11;CASP8;CREB3L2;CREB3L1
Alzheimers diseaseAPOE;NOS1;AKR1C1;PPP3R1;PPP3CB;COX7A2L;SDHA;SNCA;LPL
Chagas disease (American trypanosomiasis)CXCL8;IL1B2;PLCB3;PIK3CG;MAPK3;AKT2;C1QA;MAPK9;CALR
TuberculosisIL1B;ATP6V0A2;RELA;IL12B;FCGR3B;ATP6V0B;HLA-DRB3;CAMK2A;CORO1A
Hepatitis BMAP2K4;PIK3R3;TNF;NRAS;FOS;Ifna11;VDAC3;MYD88;RB1
Herpes simplex infectionIL12B;PER1B;MAPK8B;IFNA3;H2-AB1;SFRS3B;PILRA;IL15;HLA-DOA
Pathways in cancerFGF16;WNT11;LAMA5;TCF7L2;BID;TCEB1;AGTR1A;PRKACB;PTGER4

FADD has several biochemical functions, for example, caspase binding, death effector domain binding, death receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FADD itself. We selected most functions FADD had, and list some proteins which have the same functions with FADD. You can find most of the proteins on our site.

Function Related Protein
caspase bindingBFAR;MAGEA3;FADD;NOL3
death effector domain bindingCFLAR;CASP8;CASP8L1;NOL3;FADD;CASP10;CFLARA
death receptor bindingTNFSF15;PRDM4;Fasl;TMBIM1;Casp3;FASLG;NOL3;MYD88;FEM1B
identical protein bindingHNRNPC;TOPBP1;MAPK1IP1;NDC80;PSME3;EWSR1;AIM2;CLDN17;MRI1
protease bindingBCL2;Cstb;CD28;MBP;SELL;CSTA;SERPINA1E;SERPINC1;SERPINB3
protein bindingCEACAM1;STK11;DUSP26;SOCS5;ORC3L;SOS1;RAB39A;PDE6H;PAM16
protein complex bindingSLC27A5;OTOF;SKAP1;GRIN2A;CD2AP;NRAS;LEPRE1;ANKRD32;CALY
tumor necrosis factor receptor bindingTNFSF10L;TRAP1;TRIM37;TRAF2;TNF;TRAF1;TNFSF4;Fasl;TNFSF15
tumor necrosis factor receptor superfamily bindingTNFSF18;TNFSF4;TNFSF11;TNFSF9;FADD

FADD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FADD here. Most of them are supplied by our site. Hope this information will be useful for your research of FADD.

FAS

Zhang, T; Wang, XY; et al. Metformin sensitizes human bladder cancer cells to TRAIL-induced apoptosis through mTOR/S6K1-mediated downregulation of c-FLIP. ANTI-CANCER DRUGS 25:887-897(2014).
Belz, K; Schoeneberger, H; et al. Smac mimetic and glucocorticoids synergize to induce apoptosis in childhood ALL by promoting ripoptosome assembly. BLOOD 124:240-250(2014).
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