|Official Full Name||F-box protein 32|
|Background||This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.|
|Synonyms||FBXO32; F-box protein 32; F box only protein 32; F-box only protein 32; ATROGIN1; Fbx32; MAFbx; 4833442G10Rik; AI430017; Atrogin 1; Atrogin-1; Atrophy gene 1; FBX32_HUMAN; fbxo25; FLJ32424; MGC108443; MGC137646; MGC33610; Muscle atrophy F box; Muscle atrophy F box protein; Muscle atrophy F-box protein|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
fbxo32 involved in several pathways and played different roles in them. We selected most pathways fbxo32 participated on our site, such as FoxO family signaling, FoxO signaling pathway, Monoamine Transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with fbxo32 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|FoxO family signaling||MST1; CSNK1G3; GADD45A; CSNK1G2; ZFAND5; FBXO32|
|FoxO signaling pathway||HRAS; IGF1R; STK11; CCNB3; PRKAB1A; MAP2K2; RBL2; RAF1B; PRKAB1; FOXO3A|
|Monoamine Transport||TPH2; SYN1; SCAMP2; TGFB1I1; HRH3; UNC13B; FBXO32; DBH|
fbxo32 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by fbxo32 itself. We selected most functions fbxo32 had, and list some proteins which have the same functions with fbxo32. You can find most of the proteins on our site.
|protein binding||PHF15; TOR1AIP2; CDKN2C; INSR; ERBB4; RADIL; CIDEB; EWSR1; HEYL; SERPINB3C|
fbxo32 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with fbxo32 here. Most of them are supplied by our site. Hope this information will be useful for your research of fbxo32.
EIF3F; MYOG; MLH1; SKP1; KDM2A