fbxo32

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fbxo32

Official Full Name F-box protein 32
Background This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms FBXO32; F-box protein 32; F box only protein 32; F-box only protein 32; ATROGIN1; Fbx32; MAFbx; 4833442G10Rik; AI430017; Atrogin 1; Atrogin-1; Atrophy gene 1; FBX32_HUMAN; fbxo25; FLJ32424; MGC108443; MGC137646; MGC33610; Muscle atrophy F box; Muscle atrophy F box protein; Muscle atrophy F-box protein
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FBXO32-12796H Recombinant Human FBXO32, GST-tagged E.coli GST
    Human FBXO32-22H Recombinant Human FBXO32 protein, His-tagged E.coli His
    Human FBXO32-237H Recombinant Human FBXO32 Protein, His-tagged E.coli His
    Human FBXO32-28812TH Recombinant Human FBXO32 Wheat Germ N/A
    Human FBXO32-3936H Recombinant Human FBXO32 Protein, GST-tagged Wheat Germ GST
    Human FBXO32-6297HCL Recombinant Human FBXO32 293 Cell Lysate HEK293 N/A
    Mouse FBXO32-5744M Recombinant Mouse FBXO32 Protein Mammalian Cell His
    Rat FBXO32-2295R Recombinant Rat FBXO32 Protein Mammalian Cell His
    Rhesus Macaque FBXO32-1663R Recombinant Rhesus monkey FBXO32 Protein, His-tagged Mammalian Cell His
    Chicken FBXO32-2644C Recombinant Chicken FBXO32 Mammalian Cell His
    Zebrafish FBXO32-11158Z Recombinant Zebrafish FBXO32 Mammalian Cell His

    fbxo32 involved in several pathways and played different roles in them. We selected most pathways fbxo32 participated on our site, such as FoxO family signaling, FoxO signaling pathway, Monoamine Transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with fbxo32 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO family signaling MST1; CSNK1G3; GADD45A; CSNK1G2; ZFAND5; FBXO32
    FoxO signaling pathway HRAS; IGF1R; STK11; CCNB3; PRKAB1A; MAP2K2; RBL2; RAF1B; PRKAB1; FOXO3A
    Monoamine Transport TPH2; SYN1; SCAMP2; TGFB1I1; HRH3; UNC13B; FBXO32; DBH

    fbxo32 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by fbxo32 itself. We selected most functions fbxo32 had, and list some proteins which have the same functions with fbxo32. You can find most of the proteins on our site.

    Function Related Protein
    protein binding PHF15; TOR1AIP2; CDKN2C; INSR; ERBB4; RADIL; CIDEB; EWSR1; HEYL; SERPINB3C

    fbxo32 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with fbxo32 here. Most of them are supplied by our site. Hope this information will be useful for your research of fbxo32.

    EIF3F; MYOG; MLH1; SKP1; KDM2A

    Ma, L; Shen, CA; et al. EXTRACELLULAR SIGNAL-REGULATED KINASE-MAMMALIAN TARGET OF RAPAMYCIN SIGNALING AND FORKHEAD-BOX TRANSCRIPTION FACTOR 3A PHOSPHORYLATION ARE INVOLVED IN TESTOSTERONE'S EFFECT ON SEVERE BURN INJURY IN A RAT MODEL. SHOCK 43:85-91(2015).
    Cappelletti, C; Galbardi, B; et al. Autophagy, Inflammation and Innate Immunity in Inflammatory Myopathies. PLOS ONE 9:-(2014).

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