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Official Full Name FK506 binding protein 1A, 12kDa
Background The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008]
Synonyms FKBP1A; FK506 binding protein 1A, 12kDa; FKBP1; PKC12; PKCI2; FKBP12; PPIASE; FKBP-12; FKBP-1A; peptidyl-prolyl cis-trans isomerase FKBP1A; rotamase; 12 kDa FKBP; calstabin 1; calstabin-1; FKBP12-Exip3; PPIase FKBP1A; immunophilin FKBP12; FK506 binding protein12; FK506-binding protein 1; FK506-binding protein 12; 12 kDa FK506-binding protein; protein kinase C inhibitor 2; FK506-binding protein 1A (12kD); FK506-binding protein, T-cell, 12-kD;
    • Species :
    • Cattle
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • Met
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FKBP1A-057H Recombinant Human FKBP1A Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human FKBP1A-1987H Recombinant Human FKBP1A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human FKBP1A-28908TH Recombinant Human FKBP1A E.coli N/A
    Human FKBP1A-28909TH Recombinant Human FKBP1A protein, His-tagged E.coli His
    Human FKBP1A-4186H Recombinant Human FKBP1A Protein, GST-tagged Wheat Germ GST
    Human FKBP1A-4845H Recombinant Human FK506 Binding Protein 1A, 12kDa, GST-tagged E.coli GST
    Human FKBP1A-503H Recombinant Human FK506 Binding Protein 1A, 12kDa, His-tagged E.coli His
    Human FKBP1A-6210HCL Recombinant Human FKBP1A 293 Cell Lysate HEK293 N/A
    Human FKBP1A-6211HCL Recombinant Human FKBP1A 293 Cell Lysate HEK293 N/A
    Human FKBP1A-621H Recombinant Human FKBP1A, Met&His-tagged E.coli Met/His
    Human FKBP1A-7000H Recombinant Human FKBP1A, GST-tagged E.coli GST
    Mouse Fkbp1a-3023M Recombinant Mouse Fkbp1a Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Fkbp1a-3098M Recombinant Mouse Fkbp1a, His tagged E.coli His
    Mouse Fkbp1a-64M Recombinant Mouse Fkbp1a, His-tagged E.coli His
    Mouse Fkbp1a-7208M Recombinant Mouse Fkbp1a Protein, His-tagged E.coli His
    Rat FKBP1A-2353R Recombinant Rat FKBP1A Protein Mammalian Cell His
    Rhesus Macaque FKBP1A-1718R Recombinant Rhesus monkey FKBP1A Protein, His-tagged Mammalian Cell His
    Chicken FKBP1A-5902C Recombinant Chicken FKBP1A Mammalian Cell His
    Cattle FKBP1A-1265C Recombinant Cattle FKBP1A protein, His-tagged E.coli His

    fkbp1a involved in several pathways and played different roles in them. We selected most pathways fkbp1a participated on our site, such as ALK1 pathway, ALK1 signaling events, ALK2 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with fkbp1a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ALK1 pathway FKBP1A; ACVRL1
    ALK1 signaling events ACVRL1; FKBP1A; GDF2; CSNK2B
    ALK2 signaling events FKBP1A
    Alpha-synuclein signaling TOR1A; PARK7; KLK6; STUB1; BLK; CSNK2A1; FKBP1A
    Calcium Regulation in the Cardiac Cell CHRM3; GJC2; RGS5A; CX30.3; ADRA1D; GJA10; RGS11; CASQ1B; RGS20; RGS6
    Calcium signaling in the CD4+ TCR pathway CHP; RCAN2; POU2F1; BATF3; AKAP5; CSF2; FKBP1A; RCAN1; JUNB
    Diseases of signal transduction JAG2; TRAT1; LRRFIP1; KREMEN2; OPN1SW; TTR; TNKS; CCNC; FGFR1OP; CTBP2

    fkbp1a has several biochemical functions, for example, FK506 binding, SMAD binding, activin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by fkbp1a itself. We selected most functions fkbp1a had, and list some proteins which have the same functions with fkbp1a. You can find most of the proteins on our site.

    Function Related Protein
    activin binding ENG; TGFBR3; SMURF1; SMAD7; FST; ACVR2B; FKBP1A; ACVRL1; FSTL3; ACVR1
    NOT calcium channel inhibitor activity FKBP1A
    ion channel binding PACS1; KCNQ1; ACTN4; VDAC1; SNTA1; KCNE1L; KCNJ11; CAV3; KCND3; SLC14A2
    macrolide binding FKBP1A
    peptidyl-prolyl cis-trans isomerase activity TTC9C; PPIG; FKBP11; FKBP1AB; FKBP1B; PPIE; FKBP14; FKBP9; PPIF; PPIC
    protein binding LIMK1; USHBP1; RABIF; SNX12; ACSS1; MAP2K1; ZNF2; IFT57; RNF144B; ATP5A1
    signal transducer activity TRHRB; OLFR18; PLCD4; OMPB; OPN4A; GNA15.4; GPR34L; CC2D1A; TICAM2; OLFCG1
    transforming growth factor beta receptor binding LFT1; BMP7A; BMP6; LEFTY2; BMP2B; GDF15; MSTNA; BMP5; LEFTY1; NDR2
    type I transforming growth factor beta receptor binding SNX25; SMAD2; ENG; TGFBR2; SMAD7; FKBP1A; TGFB3; SMAD6; TGFB1

    fkbp1a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with fkbp1a here. Most of them are supplied by our site. Hope this information will be useful for your research of fkbp1a.

    MTOR; RYR1; TGFBR1; SMAD7; AHSP; ACVR1B; sirolimus; ryr1_oncmy_protein; ryr1; EPB41; VHL; FKBP1B

    Gant, JC; Blalock, EM; et al. FK506-binding protein 1b/12.6: A key to aging-related hippocampal Ca2+ dysregulation?. EUROPEAN JOURNAL OF PHARMACOLOGY 739:74-82(2014).
    Zhang, YY; Shen, W; et al. Proteomics reveals potential non-neuronal cholinergic receptor-effectors in endothelial cells. ACTA PHARMACOLOGICA SINICA 35:1137-1149(2014).

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