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FKBP1A

  • Official Full Name

    FK506 binding protein 1A, 12kDa

  • Overview

    The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008]
  • Synonyms

    FKBP1A; FK506 binding protein 1A, 12kDa; FKBP1; PKC12; PKCI2; FKBP12; PPIASE; FKBP-12; FKBP-1A; peptidyl-prolyl cis-trans isomerase FKBP1A; rotamase; 12 kDa FKBP; calstabin 1; calstabin-1; FKBP12-Exip3; PPIase FKBP1A; immunophilin FKBP12; FK506 binding protein12; FK506-binding protein 1; FK506-binding protein 12; 12 kDa FK506-binding protein; protein kinase C inhibitor 2; FK506-binding protein 1A (12kD); FK506-binding protein, T-cell, 12-kD;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Met|His
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FKBP1A-621H Active Recombinant Human FKBP1A, Met&His-tagged E.coli Met/His
Human FKBP1A-7000H Recombinant Human FKBP1A, GST-tagged E.coli GST Full length
Human FKBP1A-4845H Recombinant Human FK506 Binding Protein 1A, 12kDa, GST-tagged E.coli GST
Human FKBP1A-28909TH Recombinant Human FKBP12 protein, His-tagged E.coli His Met1-Glu108
Human FKBP1A-28908TH Recombinant Human FKBP1A E.coli N/A
Human FKBP1A-503H Recombinant Human FK506 Binding Protein 1A, 12kDa, His-tagged E.coli His
Human FKBP1A-6210HCL Recombinant Human FKBP1A 293 Cell Lysate HEK293 N/A
Human FKBP1A-6211HCL Recombinant Human FKBP1A 293 Cell Lysate HEK293 N/A
Human FKBP1A-4186H Recombinant Human FKBP1A Protein, GST-tagged Wheat Germ GST
Human FKBP1A-1372HFL Recombinant Full Length Human FKBP1A Protein, C-Flag-tagged Mammalian cells Flag
Human FKBP1A-1987H Recombinant Human FKBP1A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FKBP1A-916H Recombinant Human FKBP1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human FKBP1A-057H Recombinant Human FKBP1A Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human FKBP1A-2920H Recombinant Human FKBP1A protein, GST-tagged E.coli GST 2-103aa
Human FKBP1A-4799HF Recombinant Full Length Human FKBP1A Protein, GST-tagged In Vitro Cell Free System GST 108 amino acids
Human FKBP1A-916H-B Recombinant Human FKBP1A Protein Pre-coupled Magnetic Beads HEK293
Human FKBP1A-2529H Recombinant Human FKBP1A Protein (Gly2-Glu108), N-His tagged E.coli N-His Gly2-Glu108
Mouse Fkbp1a-3098M Recombinant Mouse Fkbp1a, His tagged E.coli His
Mouse Fkbp1a-64M Recombinant Mouse Fkbp1a, His-tagged E.coli His
Mouse Fkbp1a-3023M Recombinant Mouse Fkbp1a Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Fkbp1a-7208M Recombinant Mouse Fkbp1a Protein, His-tagged E.coli His 1-108
Rat FKBP1A-2353R Recombinant Rat FKBP1A Protein Mammalian Cell His
Rat FKBP1A-2009R Recombinant Rat FKBP1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FKBP1A-2009R-B Recombinant Rat FKBP1A Protein Pre-coupled Magnetic Beads HEK293
Cattle FKBP1A-1265C Recombinant Cattle FKBP1A protein, His-tagged E.coli His Gly2~Glu108 (Accession # P68107)
Rhesus Macaque FKBP1A-1718R Recombinant Rhesus monkey FKBP1A Protein, His-tagged Mammalian Cell His
Rhesus Macaque FKBP1A-1540R Recombinant Rhesus Macaque FKBP1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque FKBP1A-1540R-B Recombinant Rhesus Macaque FKBP1A Protein Pre-coupled Magnetic Beads HEK293
Chicken FKBP1A-5902C Recombinant Chicken FKBP1A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FKBP1A Related Articles

FKBP1A involved in several pathways and played different roles in them. We selected most pathways FKBP1A participated on our site, such as ALK1 pathway, ALK1 signaling events, ALK2 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with FKBP1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ALK1 pathwayFKBP1A;ACVRL1
ALK1 signaling eventsCSNK2B;GDF2;ACVRL1;FKBP1A
ALK2 signaling events
Alpha-synuclein signalingFKBP1A;STUB1;PARK7;BLK;CSNK2A1;KLK6;TOR1A
Calcium Regulation in the Cardiac CellADRa1A;CASQ1;GJB5;CASQ1B;YWHAQ;CX44.1;RGS5A;RGS14;RGS17
Calcium signaling in the CD4+ TCR pathwayFKBP1A;AKAP5;RCAN1;POU2F1;JUNB;CSF2;BATF3;CHP;RCAN2
DiseaseRPL35;AP1S1;TLR10;EEF2;CPSF6;CDK8;EPM2A;RDBP;HDAC6
Diseases of signal transductionSTRA6;MYO18A;OPN1SW;OPN1MW;TRAT1;HEY1;JAG2;KREMEN2;CTBP2

FKBP1A has several biochemical functions, for example, FK506 binding, SMAD binding, activin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FKBP1A itself. We selected most functions FKBP1A had, and list some proteins which have the same functions with FKBP1A. You can find most of the proteins on our site.

Function Related Protein
FK506 bindingTTC9C;FKBP1AA;FKBP1B;FKBP8;FKBP5;FKBP14;FKBP1A;FKBP6;FKBP10
SMAD bindingEID2;PURA;SKIL;ACVR1B;EP300;SMAD2;SKOR1B;COL1A2;TGFBR1
activin bindingTGFBR3;FSTL3;ENG;FKBP1A;FST;ACVRL1;ACVR1;SMAD7;ACVR2B
NOT calcium channel inhibitor activity
ion channel bindingFYN;TRPC1;RIMS1;PPP1R9B;KCNE1L;KCNJ11;ID2;FAM115C;RANGRF
macrolide binding
peptidyl-prolyl cis-trans isomerase activityPPIB;FKBP6;RANBP2;PPIFA;FKBP10B;TTC9C;FKBP2;FKBP1A;PPP2R4
protein bindingNOC4L;COA3;IK;TNFRSF13B;SNX10;RSPO2;FOXO3;CSNK1G2;EPHA7
signal transducer activityTAS2R143;GOLT1B;FAS;GNAV1;BST2;STAT6;OMP;MC5RB;TAAR10A
transforming growth factor beta receptor bindingBMP7;LRG1;BMP3;INHBA;INHBC;SMAD2;BMP6;INHBAA;GDF3
type I transforming growth factor beta receptor bindingSMAD6;ENG;FKBP1A;TGFB3;SNX25;TGFB1;SMAD2;SMAD7;TGFBR2

FKBP1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FKBP1A here. Most of them are supplied by our site. Hope this information will be useful for your research of FKBP1A.

MTOR; RYR1; TGFBR1; SMAD7; AHSP; ACVR1B; sirolimus; ryr1_oncmy_protein; ryr1; EPB41; VHL; FKBP1B

Gant, JC; Blalock, EM; et al. FK506-binding protein 1b/12.6: A key to aging-related hippocampal Ca2+ dysregulation?. EUROPEAN JOURNAL OF PHARMACOLOGY 739:74-82(2014).
Zhang, YY; Shen, W; et al. Proteomics reveals potential non-neuronal cholinergic receptor-effectors in endothelial cells. ACTA PHARMACOLOGICA SINICA 35:1137-1149(2014).
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