Recombinant Human FK506 Binding Protein 1A, 12kDa, GST-tagged
Cat.No. : | FKBP1A-4845H |
Product Overview : | Recombinant full length human FKBP1A was expressed in E. coli cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | FKBP1A-4845H |
Description : | FKBP1A is a member of the immunophilin protein family which plays a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP1A is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and Rapamycin. FKBP1A interacts with various type I receptors, including the TGF-beta type I receptor and competitive binding assays show that the type I receptor may be a natural ligand for FKBP1A. FKBP1A-deficient mice have normal skeletal muscle but show severe dilated cardiomyopathy and ventricular septal defects that mimick a human congenital heart disorder. |
Applications : | Western Blot |
Molecular Weight : | 38.3 kDa |
Expression System : | E.coli |
Species : | Human |
Form : | Recombinant protein stored in 50 mM Tris-HCl, ph 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol. |
Purity : | > 95 % |
Concentration : | 0.2 ug/ul |
Sequences : | Full length |
Storage : | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Pathways : | ALK1 pathway; ALK2 signaling events; Alpha-synuclein signaling; Calcium Regulation in the Cardiac Cell |
Gene Name : | FKBP1A FK506 binding protein 1A, 12kDa [ Homo sapiens ] |
Official Symbol : | FKBP1A |
Synonyms : | FKBP1A; FK506 binding protein 1A, 12kDa; FKBP1; PKC12; FKBP12; PPIASE; FKBP12C; FK506-binding protein 1A (12kD); Peptidyl-prolyl cis-trans isomerase FKBP1A; PPIase FKBP1A; EC 5.2.1.8; FK506-binding protein 1A; FKBP-1A; Immunophilin FKBP12; 12 kDa FKBP; FKBP-12; OTTHUMP00000029977; OTTHUMP00000029978; OTTHUMP00000029979; OTTHUMP00000029980; Rotamase; rotamase; FK506-binding protein 1; FK506-binding protein 12; FK506-binding protein, T-cell, 12-kD; peptidyl-prolyl cis-trans isomerase; protein kinase C inhibitor 2; EC=5.2.1.8; 12 kDa FK506-binding protein; FK506-binding protein, T-cell, 12-Kd |
Gene ID : | 2280 |
mRNA Refseq : | NM_000801 |
Protein Refseq : | NP_000792 |
MIM : | 186945 |
UniProt ID : | P62942 |
Chromosome Location : | 20p13 |
Function : | FK506 binding; SMAD binding; activin binding; isomerase activity; peptidyl-prolyl cis-trans isomerase activity; ryanodine-sensitive calcium-release channel activity; signal transducer activity; transforming growth factor beta receptor activity; type I transforming growth factor beta receptor binding |
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◆ Lysates | ||
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