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FLT4

  • Official Full Name

    Fms-related tyrosine kinase 4

  • Overview

    Fms-related tyrosine kinase 4, also known as FLT4, is a protein which in humans is encoded by the FLT4 gene. This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA.
  • Synonyms

    Fms-Related Tyrosine Kinase 4; Flt-4; PCL; FLT41; LMPH1A; VEGFR3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Human
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293 cells
  • Human Cell
  • Human Cells
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • hFc
  • His
  • DDK|His
  • DYKDDDDK
  • Fc
  • Fc|His
  • His(C
  • ter)
  • GST
  • GST|His
  • His (Fc)
  • Avi
  • His|S
  • His|T7
  • human|IgG1|Fc
  • mFc
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FLT4-617H Active Recombinant Human FLT4, Fc-tagged, Biotinylated Human Cell Fc
Human FLT4-051H Active Recombinant Human FLT4 protein, Tyr25-Glu775-tagged, Biotinylated HEK293 cells His/Avi Tyr25-Glu775
Human FLT4-88H Active Recombinant Human FLT4(800-end) Protein, N-GST-tagged Sf21 GST 800-end
Human FLT4-889H Recombinant Human FLT4 protein(Met1-Ile776), hFc-tagged HEK293 C-hFc Met1-Ile776
Human FLT4-347H Recombinant Human FLT4 protein, Fc-tagged HEK293 human/IgG1/Fc 752
Human FLT4-1698H Recombinant Human Fms-Related Tyrosine Kinase 4 Mammalian cells N/A
Human FLT4-31720TH Recombinant Human FLT4 N/A
Human FLT4-37H Active Recombinant Human FLT4 protein, His-tagged HEK293 His Met1-Ile776
Human FLT4-587H Recombinant Human Fms-Related Tyrosine Kinase 4 Insect Cell N/A
Human FLT4-86H Recombinant Human Fms-related Tyrosine Kinase 4, 7 Domains, His-tagged Insect Cell His
Human FLT4-85H Recombinant Human Fms-related Tyrosine Kinase 4, 7 Domains, Fc-tagged Insect Cell Fc
Human FLT4-31718TH Recombinant Human FLT4, His-tagged His
Human FLT4-161H Recombinant Human Fms-related Tyrosine Kinase 4, His-tagged Insect Cell His
Human FLT4-583H Recombinant Human Fms-Related Tyrosine Kinase 4, Fc Chimera Insect Cell Fc
Human FLT4-31719TH Recombinant Human FLT4 Insect Cell N/A
Human FLT4-720H Recombinant Human Fms-Related Tyrosine Kinase 4, GST-His Sf9 Insect Cell GST
Human FLT4-238H Recombinant Human FLT4 protein, His/S-tagged E.coli His/S
Human FLT4-548H Recombinant Human Fms-Related Tyrosine Kinase 4, GST-tagged Sf9 Insect Cell GST
Human FLT4-940H Recombinant Human FLT4 Protein, DDK/His-tagged HEK293 DDK/His
Human FLT4-2709HCL Recombinant Human FLT4 cell lysate Human Cell N/A
Human FLT4-4377H Active Recombinant Human FLT4 Protein, GST/His-tagged Insect Cell GST/His
Human FLT4-151H Recombinant Human FLT4 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human FLT4-2055H Recombinant Human FLT4 Protein, Fc/His-tagged HEK293 Fc/His Tyr25-Ile776
Human FLT4-8117H Active Recombinant Human FLT4 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Tyr 25 - Ile 776
Human FLT4-4378H Active Recombinant Human FLT4 Protein, GST-tagged Insect Cell GST
Human FLT4-37HAF555 Recombinant Human FLT4 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 763
Human FLT4-4413H Recombinant Human FLT4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human FLT4-478H Recombinant Human FLT4 Protein, Fc-tagged HEK293 Fc 1363
Human FLT4-4379H Recombinant Human FLT4 Protein, GST-tagged Wheat Germ GST
Human FLT4-889HAF555 Recombinant Human FLT4 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 990
Human FLT4-1318H Recombinant Human FLT4 Protein (M800-Y1363), GST tagged Insect Cell GST M800-Y1363
Human FLT4-2654H Active Recombinant Human FLT4 protein, hFc&His-tagged HEK293 hFc&His Tyr25-Ile776
Human FLT4-37HAF488 Recombinant Human FLT4 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 763
Human FLT4-37HAF647 Recombinant Human FLT4 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 763
Human FLT4-4413H-B Recombinant Human FLT4 Protein Pre-coupled Magnetic Beads HEK293
Human FLT4-889HAF647 Recombinant Human FLT4 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 990
Human FLT4-889HAF488 Recombinant Human FLT4 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 990
Human FLT4-37HF Recombinant Human FLT4 Protein, His-tagged, FITC conjugated HEK293 His 763
Human FLT4-0239H Active Recombinant Human FLT4 protein, His-tagged HEK293 His Met1-Asn756
Human FLT4-889HF Recombinant Human FLT4 Protein, Fc-tagged, FITC conjugated HEK293 Fc 990
Human FLT4-1317H Recombinant Human FLT4 Protein (M800-Y1363), Tag Free Insect Cell No tag M800-Y1363
Human FLT4-101H Recombinant Human FLT4 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Tyr25-Ile776
Human FLT4-0830H Active Recombinant Human FLT4 protein, Fc-tagged HEK293 Fc Tyr25-Ile776
Human FLT4-3030H Recombinant Human FLT4 Protein (Ser473-Ile776), N-His tagged E.coli N-His Ser473-Ile776
Human FLT4-3031H Recombinant Human FLT4 Protein (473-776), His tagged E.coli His 473-776
Mouse Flt4-281M Active Recombinant Mouse Flt4 protein(Met1-Glu775), hFc-tagged HEK293 C-hFc Met1-Glu775
Mouse Flt4-239M Recombinant Mouse Flt4 protein, His/S-tagged E.coli His/S
Mouse Flt4-1787M Recombinant Mouse FMS-like Tyrosine Kinase 4 Sf21 Insect Cell N/A
Mouse Flt4-1942M Recombinant Mouse Flt4 protein, His & T7-tagged E.coli His/T7 Pro30~Ile326 (Accession # P35917)
Mouse Flt4-282M Active Recombinant Mouse Flt4 protein(Met1-Glu775), His-tagged HEK293 C-His Met1-Glu775
Mouse FLT4-2016MCL Recombinant Mouse FLT4 cell lysate Human Cell N/A
Mouse FLT4-391M Active Recombinant Mouse FLT4 protein, mFc-tagged HEK293 mFc Tyr 25 - Asp 770
Mouse Flt4-282MAF488 Recombinant Mouse Flt4 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 762
Mouse Flt4-281MAF555 Recombinant Mouse Flt4 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 9922
Mouse Flt4-281MAF488 Recombinant Mouse Flt4 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 9922
Mouse Flt4-282MAF555 Recombinant Mouse Flt4 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 762
Mouse Flt4-281MF Recombinant Mouse Flt4 Protein, Fc-tagged, FITC conjugated HEK293 Fc 9922
Mouse Flt4-282MF Recombinant Mouse Flt4 Protein, His-tagged, FITC conjugated HEK293 His 762
Mouse Flt4-281MAF647 Recombinant Mouse Flt4 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 9922
Mouse Flt4-282MAF647 Recombinant Mouse Flt4 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 762
Rat FLT4-2365R Recombinant Rat FLT4 Protein Mammalian Cell His
Rat Tnf-240R Recombinant Rat Flt4 protein, His-tagged E.coli His
Rat FLT4-2021R Recombinant Rat FLT4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FLT4-2021R-B Recombinant Rat FLT4 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish FLT4-8585Z Recombinant Zebrafish FLT4 Mammalian Cell His
Chicken FLT4-5522C Recombinant Chicken FLT4 Mammalian Cell His
Kit-1594 Flt4 Activity Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

FLT4 involved in several pathways and played different roles in them. We selected most pathways FLT4 participated on our site, such as Ras signaling pathway, Rap signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with FLT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwayANGPT4;GNG5;PDGFRA;RASGRP3;RELA;PLA2G2E;FGF22;MRAS;PLA2G3
Rap signaling pathwayCALM2;FGF5;NGFR;CDC42;RAC3;ITGB1;INSR;FIGF;FGF21
Cytokine-cytokine receptor interactionMPL;IL2RB;GDF5;XCL1;IL7;CXCL8B.3;IL13RA1;CXCR4;PDGFB
PIK-Akt signaling pathwayMAP2K2;GNB2;PPP2R5C;IL4;GNB3;PDGFRB;PDGFRA;LAMB1;ATF4
Focal adhesionVTNB;HGF;MYL5;SEPP1;CAPN2L;PGF;PAK6;MYLK;SOS1

FLT4 has several biochemical functions, for example, ATP binding, growth factor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FLT4 itself. We selected most functions FLT4 had, and list some proteins which have the same functions with FLT4. You can find most of the proteins on our site.

Function Related Protein
ATP bindingCBWD1;NEK10;PIK3CG;STK3;AK5L;LATS1;UBE2H;CLCN7;IKBKE
growth factor bindingA2M;IGFBP2A;KDR;LTBP2;NRP2;GHR;ACVR1C;BMPR2;ACVR2A
protein bindingFAM120B;LATS1;ZNF18;RAD9A;UBR2;PEPD;ZZZ3;EPS15;SRSF3
protein phosphatase bindingMAP3K5;ERBB2;RPA2;DLG4;RPA3;MVP;PARD3;DRD1;ANAPC4
transmembrane receptor protein tyrosine kinase activityEPHB4A;TEK;FLT1;KITB;CSF1RA;KIT;EPHB4B;TIE1;IGF1RA
vascular endothelial growth factor-activated receptor activityNRP1A;NRP2B;NRP1B;KDR;FLT1;NRP2A;FLT3;PDGFRA;FLT4

FLT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FLT4.

KDR; HSP90AB1; PKM; LRRK1; IKBKG; VEGFC; ATF7IP

Research Area

Related articles

Jurisic, G; Sundberg, JP; et al. Blockade of VEGF Receptor-3 Aggravates Inflammatory Bowel Disease and Lymphatic Vessel Enlargement. INFLAMMATORY BOWEL DISEASES 19:1983-1989(2013).
von Kaisenberg, CS; Wilting, J; et al. Lymphatic capillary hypoplasia in the skin of fetuses with increased nuchal translucency and Turner's syndrome: comparison with trisomies and controls. MOLECULAR HUMAN REPRODUCTION 16:778-789(2010).
  • Q&As
  • Reviews

Q&As (6)

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Does FLT4 protein correlate with tumor-related markers? 09/14/2022

FLT4 protein is associated with various tumor-related markers such as malignant lymphoma, breast cancer, and lung cancer.

Is there a relationship between FLT4 protein and lymphedema? 04/16/2022

FLT4 protein is a key regulator of lymphedema and plays an important role in lymphangiogenesis and lymphatic drainage.

Is FLT4 protein associated with congenital lymphedema? 06/01/2021

Yes, mutations in the FLT4 protein can lead to congenital lymphedema, a condition caused by abnormal lymphatic vessel development.

What is the potential of FLT4 protein in cancer treatment? 10/16/2020

The protein is considered an important target in anticancer therapy, and inhibition of its activity may reduce tumor angiogenesis and metastasis.

What is the role of FLT4 protein in pulmonary hypertension? 07/16/2020

FLT4 protein plays an important role in pulmonary hypertension, and upregulation of its activity may lead to pathological changes such as vascular remodeling and pulmonary artery stenosis.

What is the role of FLT4 protein in angiogenesis? 04/21/2019

This is involved in the regulation of angiogenesis and lymphangiogenesis by binding to vascular endothelial growth factor C (VEGF-C) and vascular endothelial growth factor D (VEGF-D).

Customer Reviews (3)

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Reviews
09/05/2022

    The catalytic activity of FLT4 is very strong, which can significantly improve the selectivity and yield of chemical reactions, and its application potential is great.

    09/26/2019

      We were reassured that the quality of FLT4 was consistent.

      03/23/2019

        Using FLT4 for experiments, I can focus more on experimental design and data analysis without worrying about the reproducibility of experimental results.

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