FLT4

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FLT4

Official Full Name Fms-related tyrosine kinase 4
Background Fms-related tyrosine kinase 4, also known as FLT4, is a protein which in humans is encoded by the FLT4 gene. This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA.
Synonyms Fms-Related Tyrosine Kinase 4; Flt-4; PCL; FLT41; LMPH1A; VEGFR3
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293 cells
    • Human Cell
    • Human Cells
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • DDK
    • His
    • DYKDDDDK
    • Fc
    • GST
    • His/Avi
    • Avi
    • S
    • T7
    • human
    • IgG1
    • Mouse
    • IgG2a
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FLT4-051H Recombinant Human FLT4 protein, Tyr25-Glu775-tagged, Biotinylated HEK293 cells His/Avi
    Human FLT4-151H Recombinant Human FLT4 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
    Human FLT4-161H Recombinant Human Fms-related Tyrosine Kinase 4, His-tagged Insect Cell His
    Human FLT4-1698H Recombinant Human Fms-Related Tyrosine Kinase 4 Mammalian cells N/A
    Human FLT4-2055H Recombinant Human FLT4 Protein, Fc/His-tagged HEK293 Fc/His
    Human FLT4-238H Recombinant Human FLT4 protein, His/S-tagged E.coli His/S
    Human FLT4-2709HCL Recombinant Human FLT4 cell lysate Human Cell N/A
    Human FLT4-31718TH Recombinant Human FLT4, His-tagged His
    Human FLT4-31719TH Recombinant Human FLT4 Insect Cell N/A
    Human FLT4-31720TH Recombinant Human FLT4 N/A
    Human FLT4-347H Recombinant Human FLT4 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human FLT4-37H Recombinant Human FLT4, His tagged Human Cell His
    Human FLT4-4377H Recombinant Human FLT4 Protein, GST/His-tagged Insect Cell GST/His
    Human FLT4-4378H Recombinant Human FLT4 Protein, GST-tagged Insect Cell GST
    Human FLT4-4379H Recombinant Human FLT4 Protein, GST-tagged Wheat Germ GST
    Human FLT4-548H Recombinant Human Fms-Related Tyrosine Kinase 4, GST-tagged Sf9 Insect Cell GST
    Human FLT4-583H Recombinant Human Fms-Related Tyrosine Kinase 4, Fc Chimera Insect Cell Fc
    Human FLT4-587H Recombinant Human Fms-Related Tyrosine Kinase 4 Insect Cell N/A
    Human FLT4-617H Recombinant Human FLT4, Fc-tagged, Biotinylated Human Cell Fc
    Human FLT4-720H Recombinant Human Fms-Related Tyrosine Kinase 4, GST-His Sf9 Insect Cell GST
    Human FLT4-8117H Recombinant Human FLT4 protein, His & Avi-tagged, Biotinylated HEK293 His/Avi
    Human FLT4-85H Recombinant Human Fms-related Tyrosine Kinase 4, 7 Domains, Fc-tagged Insect Cell Fc
    Human FLT4-86H Recombinant Human Fms-related Tyrosine Kinase 4, 7 Domains, His-tagged Insect Cell His
    Human FLT4-889H Recombinant Human FLT4, Fc tagged Human Cell Fc
    Human FLT4-940H Recombinant Human FLT4 Protein, DDK/His-tagged HEK293 DDK/His
    Mouse Flt4-1787M Recombinant Mouse FMS-like Tyrosine Kinase 4 Sf21 Insect Cell N/A
    Mouse Flt4-1942M Recombinant Mouse Flt4 protein, His & T7-tagged E.coli His/T7
    Mouse FLT4-2016MCL Recombinant Mouse FLT4 cell lysate Human Cell N/A
    Mouse Flt4-239M Recombinant Mouse Flt4 protein, His/S-tagged E.coli His/S
    Mouse Flt4-281M Recombinant Mouse Flt4, Fc tagged Human Cell Fc
    Mouse Flt4-282M Recombinant Mouse Flt4, His tagged Human Cell His
    Mouse FLT4-391M Recombinant Mouse FLT4 protein, Mouse IgG2a Fc-tagged, low endotoxin HEK293 Mouse/IgG2a/Fc
    Rat FLT4-2365R Recombinant Rat FLT4 Protein Mammalian Cell His
    Rat Tnf-240R Recombinant Rat Flt4 protein, His-tagged E.coli His
    Chicken FLT4-5522C Recombinant Chicken FLT4 Mammalian Cell His
    Zebrafish FLT4-8585Z Recombinant Zebrafish FLT4 Mammalian Cell His
    Kit-1594 Flt4 Activity Assay Kit N/A

    FLT4 involved in several pathways and played different roles in them. We selected most pathways FLT4 participated on our site, such as Ras signaling pathway, Rap signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with FLT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway GRIN1; FGF14; IGF1; ANGPT1; CALM4; ETS2; PLA2G10; PIK3R5; PAK3; Pdgfa&Pdgfb
    Rap signaling pathway FGF18; FGF14; PDGFB; SIPA1L2; PRKD1; PDGFRB; GNAI3; MAP2K1; RAPGEF6; GRIN1
    Cytokine-cytokine receptor interaction IL4; Ccl21a; IL17RB; IFNE; IFNA16; IL15RA; Flt3l; TNFB; CXCR4A; IL22RA1
    PIK-Akt signaling pathway IFNB1; IFNA16; FN1; THBS3; FGF10; PIK3CB; IRS1; FGF22; G6PC2; CCND1
    Focal adhesion Itga10&Itgb1; HRASB; TLN1; SEPP1; PARVAA; DIAPH1; ACTN3B; THBS3A; ITGA3; ARHGAP5

    FLT4 has several biochemical functions, for example, ATP binding, growth factor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FLT4 itself. We selected most functions FLT4 had, and list some proteins which have the same functions with FLT4. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding PTK2AA; PRKCA; RIOK3; RUVBL1; YARS; MAST2; ATAD1; UBE2G1A; KIF3C; KIFC2
    growth factor binding RHBDF2; ACVR2B; NKD2; NRP1; GHR; IL6ST; ACVR2A; HTRA1A; RHBDF1; RPL37
    protein binding SLC38A2; CEP68; CREBBP; TNFSF14; LRSAM1; PDCD4; CA8; TPM3; RAB25; SOX9A
    protein phosphatase binding TRP53; PIK3R1; MET; CDC27; NEK2; PIK3R2; TP53; CDH2; MAPK14; HSF4
    transmembrane receptor protein tyrosine kinase activity EPHA4B; CADM2B; ALK; EK1; KDRL; TRIM27; MUSK; RYK; NTRK2B; FLT3
    vascular endothelial growth factor-activated receptor activity FLT3; NRP2A; NRP1A; NRP1; FLT4; NRP1B; NRP2; PDGFRA; KDR; NRP2B

    FLT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FLT4.

    KDR; HSP90AB1; PKM; LRRK1; IKBKG; VEGFC; ATF7IP

    Jurisic, G; Sundberg, JP; et al. Blockade of VEGF Receptor-3 Aggravates Inflammatory Bowel Disease and Lymphatic Vessel Enlargement. INFLAMMATORY BOWEL DISEASES 19:1983-1989(2013).
    von Kaisenberg, CS; Wilting, J; et al. Lymphatic capillary hypoplasia in the skin of fetuses with increased nuchal translucency and Turner's syndrome: comparison with trisomies and controls. MOLECULAR HUMAN REPRODUCTION 16:778-789(2010).

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