FLT4
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Official Full Name
Fms-related tyrosine kinase 4
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Overview
Fms-related tyrosine kinase 4, also known as FLT4, is a protein which in humans is encoded by the FLT4 gene. This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. -
Synonyms
Fms-Related Tyrosine Kinase 4; Flt-4; PCL; FLT41; LMPH1A; VEGFR3;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
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- Human
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- Wheat Germ
- Fc
- Flag
- GST
- His
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- T7
- mFc
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
FLT4 involved in several pathways and played different roles in them. We selected most pathways FLT4 participated on our site, such as Ras signaling pathway, Rap signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with FLT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | FGFR3;ZAP70;GNG8;MLLT4;RASGRF2;PLCG2;LAT;NRAS;TBK1 |
| Rap signaling pathway | VEGFA;FIGF;GNAQ;NRAS;FGF18;FGF4;LCP2;KRIT1;RAP1A |
| Cytokine-cytokine receptor interaction | IL2RGA;CXCR3.2;CCR8L;NGFR;IL26;CX3CR1;GM13305;TNFSF8;GM2506 |
| PIK-Akt signaling pathway | ITGB4;PPP2R3C;PPP2R5C;VTN;ITGA10;IFNA5;TNC;PPP2R2B;PDGFRA |
| Focal adhesion | MAPK10;PIK3CA;TNK2;SHC4;SHC2;EGFRA;HRASA;BCAR1;PDGFAB |
FLT4 has several biochemical functions, for example, ATP binding, growth factor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FLT4 itself. We selected most functions FLT4 had, and list some proteins which have the same functions with FLT4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ATP13A5;THRAP3;PRKG2;MARK3;NLRP9C;ITPKB;NLRP2;LYN;KIF23 |
| growth factor binding | HTRA1A;RPL37;SDCBP;NRP2;HTRA1B;ACVR2A;GHR;IGFBP2A;IGFBP2B |
| protein binding | DNAJC19;EED;PARD6A;AP1B1;TGIF2LY;CLIC5;EIF5A;PLK1;MYH7B |
| protein phosphatase binding | STAT3;PIK3R2;PARD3;PPP1R3G;DRD1;STAT6;MAP2K7;PIK3R1;TRAF2 |
| transmembrane receptor protein tyrosine kinase activity | CSF1RA;ERBB3B;KDRL;MUSK;FLT1;ERBB4;NPTN;ALK;ROR1 |
| vascular endothelial growth factor-activated receptor activity | NRP2;KDR;NRP1;NRP1B;NRP2A;PDGFRA;FLT3;FLT1;NRP1A |
FLT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FLT4.
KDR; HSP90AB1; PKM; LRRK1; IKBKG; VEGFC; ATF7IP
Research Area
Related articles
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Customer Reviews (3)
Write a reviewThe catalytic activity of FLT4 is very strong, which can significantly improve the selectivity and yield of chemical reactions, and its application potential is great.
We were reassured that the quality of FLT4 was consistent.
Using FLT4 for experiments, I can focus more on experimental design and data analysis without worrying about the reproducibility of experimental results.
Q&As (6)
Ask a questionFLT4 protein is associated with various tumor-related markers such as malignant lymphoma, breast cancer, and lung cancer.
FLT4 protein is a key regulator of lymphedema and plays an important role in lymphangiogenesis and lymphatic drainage.
Yes, mutations in the FLT4 protein can lead to congenital lymphedema, a condition caused by abnormal lymphatic vessel development.
The protein is considered an important target in anticancer therapy, and inhibition of its activity may reduce tumor angiogenesis and metastasis.
FLT4 protein plays an important role in pulmonary hypertension, and upregulation of its activity may lead to pathological changes such as vascular remodeling and pulmonary artery stenosis.
This is involved in the regulation of angiogenesis and lymphangiogenesis by binding to vascular endothelial growth factor C (VEGF-C) and vascular endothelial growth factor D (VEGF-D).
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