Recombinant Rat Flt4 protein, His-tagged
Cat.No. : | Tnf-240R |
Product Overview : | Recombinant Rat Flt4 fused with His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). The VEGFR3 protein is expressed mainly on lymphatic vessels but it is also up-regulated in tumor angiogenesis. Mutations in VEGFR3 have been identified in patients with primary lymphoedema. The VEGF-C/VEGF-D/VEGFR3 signaling pathway may provide a target for antilymphangiogenic therapy in prostate cancer, breast cancer, gastric cancer, lung cancer, non-small cell lung cancer (NSCLC), and so on. |
Source : | E. coli |
Species : | Rat |
Tag : | His |
Form : | Lyophilized from sterile PBS, pH 7.4 |
Purity : | > 95 % as determined by SDS-PAGE |
Storage : | Store at -70 centigrade. Avoid repeated freeze/thaw cycles. |
Gene Name : | Flt4 fms-related tyrosine kinase 4 [ Rattus norvegicus ] |
Official Symbol : | Flt4 |
Synonyms : | FLT4; fms-related tyrosine kinase 4; vascular endothelial growth factor receptor 3; FLT-4; VEGFR-3; FMS-like tyrosine kinase 4; tyrosine-protein kinase receptor FLT4; Vegfr3; |
Gene ID : | 114110 |
mRNA Refseq : | NM_053652 |
Protein Refseq : | NP_446104 |
UniProt ID : | Q91ZT1 |
Chromosome Location : | 10q21 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Focal adhesion, organism-specific biosystem; Focal adhesion, conserved biosystem; Signal Transduction, organism-specific biosystem; Signaling by VEGF, organism-specific biosystem; VEGF binds to VEGFR leading to receptor dimerization, organism-specific biosystem; |
Function : | ATP binding; growth factor binding; growth factor binding; nucleotide binding; protein phosphatase binding; receptor activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor-activated receptor activity; vascular endothelial growth factor-activated receptor activity; vascular endothelial growth factor-activated receptor activity; |
Products Types
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◆ Lysates | ||
FLT4-2016MCL | Recombinant Mouse FLT4 cell lysate | +Inquiry |
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◆ Assay kits | ||
Kit-1594 | Flt4 Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionFLT4 protein is associated with various tumor-related markers such as malignant lymphoma, breast cancer, and lung cancer.
FLT4 protein is a key regulator of lymphedema and plays an important role in lymphangiogenesis and lymphatic drainage.
Yes, mutations in the FLT4 protein can lead to congenital lymphedema, a condition caused by abnormal lymphatic vessel development.
The protein is considered an important target in anticancer therapy, and inhibition of its activity may reduce tumor angiogenesis and metastasis.
FLT4 protein plays an important role in pulmonary hypertension, and upregulation of its activity may lead to pathological changes such as vascular remodeling and pulmonary artery stenosis.
This is involved in the regulation of angiogenesis and lymphangiogenesis by binding to vascular endothelial growth factor C (VEGF-C) and vascular endothelial growth factor D (VEGF-D).
Customer Reviews (3)
Write a reviewThe catalytic activity of FLT4 is very strong, which can significantly improve the selectivity and yield of chemical reactions, and its application potential is great.
We were reassured that the quality of FLT4 was consistent.
Using FLT4 for experiments, I can focus more on experimental design and data analysis without worrying about the reproducibility of experimental results.
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