FOLH1

  • Official Full Name

    folate hydrolase (prostate-specific membrane antigen) 1

  • Overview

    This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
  • Synonyms

    FOLH1; folate hydrolase (prostate-specific membrane antigen) 1; PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; NAALAdase; glutamate carboxypeptidase 2; NAALADase I; glutamate carboxylase II; glutamate carboxypeptidase II; membrane glutamate carboxypeptidase; cell growth-inhibiting gene 27 protein; folylpoly-gamma-glutamate carboxypeptidase; prostate specific membrane antigen variant F; pteroylpoly-gamma-glutamate carboxypeptidase; N-acetylated alpha-linked acidic dipeptidase 1; N-acetylated-alpha-linked acidic dipeptidase I;

  • Recombinant Proteins
  • Chromatography Reagents
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Sus scrofa (Pig)
  • Baculovirus-Insect cells
  • CHO
  • CHO cells
  • E. coli
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Human cells
  • In Vitro Cell Free System
  • Insect Cells
  • Insects cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • human IgG1 Fc
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • Strep
  • TwinStrep
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FOLH1-2415H Active Recombinant Human FOLH1, His-tagged CHO His
Human FOLH1-051H Active Recombinant Human FOLH1 protein, His/Avi/N-terminal-tagged, Biotinylated CHO cells His/Avi Lys44-Ala750
Human FOLH1-2416H Active Recombinant Human FOLH1 protein, His-tagged HEK293 His Lys 44 - Ala 750
Human FOLH1-7844H Recombinant Human FOLH1 protein, His-tagged E.coli His Ala274~Leu587
Human FOLH1-2414H Recombinant Human Folate Hydrolase, GST-tagged E.coli GST
Human FOLH1-31003TH Recombinant Human FOLH1 E.coli N/A 150 amino acids
Human FOLH1-744H Recombinant Human FOLH1 protein, His-tagged E. coli His 45-385 aa
Human PSMA-012M FOLH1-coupled magnetic beads
Human FOLH1-2416HAF488 Recombinant Human FOLH1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His Lys44-Ala750, 725
Human FOLH1-931H-B Recombinant Human FOLH1 Protein Pre-coupled Magnetic Beads HEK293
Human FOLH1-784H Recombinant Human FOLH1 protein, His-tagged HEK293 His Lys44-Ala750
Human FOLH1-02H Recombinant Human FOLH1 Protein, His-tagged Insects cell His 44-750aa
Human FOLH1-0534H Recombinant Human FOLH1 Protein (Lys44-Ala750), N-TwinStrep-tagged Baculovirus-Insect cells N-TwinStrep Lys44-Ala750
Human FOLH1-4147H Recombinant Human FOLH1 Protein (Lys44-Ala750), N-Strep tagged Insect Cells N-Strep Lys44-Ala750
Human FOLH1-2416HAF647 Recombinant Human FOLH1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His Lys44-Ala750, 725
Human FOLH1-5274H Recombinant Human FOLH1 protein, His-tagged E.coli His 48-750aa
Human FOLH1-2430H Recombinant Human FOLH1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human FOLH1-6477H Recombinant Human FOLH1 protein, Fc-tagged HEK293 human IgG1 Fc Lys44-Ala750
Human FOLH1-187HFL Recombinant Full Length Human FOLH1 Protein, C-Flag-tagged Mammalian cells Flag
Human FOLH1-2416HAF555 Recombinant Human FOLH1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His Lys44-Ala750, 725
Human FOLH1-4417H Recombinant Human FOLH1 Protein, GST-tagged Wheat Germ GST
Human FOLH1-151H Recombinant Human FOLH1 Protein, His-tagged Human cells His
Human FOLH1-4692H Active Recombinant Human FOLH1 Protein, His-tagged, APC-Labeled HEK293 His Lys 44 - Ala 750
Human FOLH1-5034HF Recombinant Full Length Human FOLH1 Protein, GST-tagged In Vitro Cell Free System GST 719 amino acids
Human FOLH1-2281H Recombinant Human FOLH1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FOLH1-2416HF Recombinant Human FOLH1 Protein, His-tagged, FITC conjugated HEK293 His Lys44-Ala750, 725
Human FOLH1-2416HB Recombinant Human FOLH1 protein, His-tagged, Biotinylated HEK293 His
Human FOLH1-931H Recombinant Human FOLH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Folh1-7845M Recombinant Mouse Folh1 protein, His & T7-tagged E.coli His/T7 Arg536~Ala752 (Accession # O35409)
Mouse Folh1-907M Recombinant Mouse Folh1 protein, His-tagged HEK293 His Ile44-Ala752
Mouse FOLH1-2452MCL Recombinant Mouse FOLH1 cell lysate Human Cell N/A
Mouse Folh1-907MAF647 Recombinant Mouse Folh1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 725
Mouse Folh1-907MAF488 Recombinant Mouse Folh1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 725
Mouse Folh1-907MF Recombinant Mouse Folh1 Protein, His-tagged, FITC conjugated HEK293 His 725
Mouse Folh1-907MAF555 Recombinant Mouse Folh1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 725
Rat FOLH1-2379R Recombinant Rat FOLH1 Protein Mammalian Cell His
Rat FOLH1-2035R-B Recombinant Rat FOLH1 Protein Pre-coupled Magnetic Beads HEK293
Rat FOLH1-2035R Recombinant Rat FOLH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL17311HF Recombinant Full Length Human Glutamate Carboxypeptidase 2(Folh1) Protein, His-Tagged E.coli expression system His Full Length (1-750)
Mus musculus (Mouse) RFL25880MF Recombinant Full Length Mouse Glutamate Carboxypeptidase 2(Folh1) Protein, His-Tagged E.coli expression system His Full Length (1-752)
Rattus norvegicus (Rat) RFL31721RF Recombinant Full Length Rat Glutamate Carboxypeptidase 2(Folh1) Protein, His-Tagged E.coli expression system His Full Length (1-752)
Sus scrofa (Pig) RFL3425SF Recombinant Full Length Pig Glutamate Carboxypeptidase 2(Folh1) Protein, His-Tagged E.coli expression system His Full Length (1-751)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FOLH1 Related Articles
  • FOLH1 Related Research Area

FOLH1 involved in several pathways and played different roles in them. We selected most pathways FOLH1 participated on our site, such as Alanine, aspartate and glutamate metabolism, Metabolic pathways, Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOLH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Alanine, aspartate and glutamate metabolismCAD;ADSSL;GOT2A;AGXT2;IL4I1;ASPA;ABAT;ADSL;GAD1
Metabolic pathwaysNT5C2;UROC1;TPI1A;SI;HSD3B6;HSD17B7;ACOT1;ALG8;ALDH3A1
Vitamin digestion and absorptionSLC19A1;BTD;SLC19A3;PNLIP;MMACHC;APOB;SLC52A3;ABCC1;GIF

FOLH1 has several biochemical functions, for example, Ac-Asp-Glu binding, dipeptidase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOLH1 itself. We selected most functions FOLH1 had, and list some proteins which have the same functions with FOLH1. You can find most of the proteins on our site.

Function Related Protein
Ac-Asp-Glu binding
dipeptidase activityDPEP2;FOLH1;SCRN2;PEPD;SCRN3;DPEP3;CNDP2;SCRN1;NAALADL1
metal ion bindingCECR1A;ZNF577;ZBTB5;SHRPRBCK1R;PRKD2;ZFP692;C2;ELOF1;ZFP516
metallocarboxypeptidase activityCPA1;AGBL5;PEPD;AGBL4;AGBL2;CPM;CPB1;CPD;AGBL1
peptidase activityCAPN11;NAALADL1;Gzmg;DHH;PRSS52;KLK1B24;CASP9;DESI1;ADAM25
tetrahydrofolyl-poly(glutamate) polymer binding

FOLH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOLH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOLH1.

Dlg4; RPS3; MTAP; MME

Haffner, MC; Laimer, J; et al. High expression of prostate-specific membrane antigen in the tumor-associated neo-vasculature is associated with worse prognosis in squamous cell carcinoma of the oral cavity. MODERN PATHOLOGY 25:1079-1085(2012).
Haffner, MC; Kronberger, IE; et al. Prostate-specific membrane antigen expression in the neovasculature of gastric and colorectal cancers. HUMAN PATHOLOGY 40:1754-1761(2009).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
What advancements have been made in FOLH1-targeted therapies recently? 03/16/2021

New radioligands and imaging agents with enhanced specificity and reduced off-target effects are being developed for more effective treatment.

How does targeting FOLH1 impact treatment precision? 01/27/2021

Targeting FOLH1 helps deliver treatments directly to cancer cells, minimizing damage to healthy tissues, thus improving treatment precision.

Are there other potential applications of FOLH1 beyond prostate cancer? 03/16/2018

Yes, research suggests potential roles in imaging and therapy for other cancers expressing FOLH1, such as renal cell carcinoma and certain types of gliomas.

Can FOLH1 be used for early cancer detection? 11/19/2017

Yes, FOLH1-based imaging techniques show promise in detecting cancer at early stages, aiding in timely intervention and improved outcomes.

Are there ongoing clinical trials exploring FOLH1's applications? 03/25/2016

Yes, numerous trials investigate FOLH1-targeted imaging and therapies in various cancers, aiming to expand its clinical utility.

Customer Reviews (3)

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Reviews
09/05/2019

    It has been shown to play a crucial role in multiple cellular processes, making it highly valuable for investigations into cell signaling, inflammation, and immune responses.

    01/28/2018

      Incorporating the FOLH1 protein into your research will not only meet but exceed your expectations, enabling you to advance your scientific discoveries with confidence.

      06/06/2016

        Researchers can leverage the unique properties of the FOLH1 protein to gain insights into its biological functions and its impact on disease mechanisms.

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