FOLH1
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Official Full Name
folate hydrolase (prostate-specific membrane antigen) 1
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Overview
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010] -
Synonyms
FOLH1; folate hydrolase (prostate-specific membrane antigen) 1; PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; NAALAdase; glutamate carboxypeptidase 2; NAALADase I; glutamate carboxylase II; glutamate carboxypeptidase II; membrane glutamate carboxypeptidase; cell growth-inhibiting gene 27 protein; folylpoly-gamma-glutamate carboxypeptidase; prostate specific membrane antigen variant F; pteroylpoly-gamma-glutamate carboxypeptidase; N-acetylated alpha-linked acidic dipeptidase 1; N-acetylated-alpha-linked acidic dipeptidase I;
- Recombinant Proteins
- Chromatography Reagents
- Protein Pre-coupled Magnetic Beads
- Cell & Tissue Lysates
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Sus scrofa (Pig)
- Baculovirus-Insect cells
- CHO
- CHO cells
- E. coli
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human Cell
- Human cells
- In Vitro Cell Free System
- Insect Cells
- Insects cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- human IgG1 Fc
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Strep
- TwinStrep
- Involved Pathway
- Protein Function
- Interacting Protein
- FOLH1 Related Articles
- FOLH1 Related Research Area
FOLH1 involved in several pathways and played different roles in them. We selected most pathways FOLH1 participated on our site, such as Alanine, aspartate and glutamate metabolism, Metabolic pathways, Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOLH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alanine, aspartate and glutamate metabolism | GLULB;GAD1;RIMKLB;GPT2;RIMKLA;GLULC;GLULA;PPAT;ASL2 |
| Metabolic pathways | CYP2J6;CYP21A2;MTHFD1;DHDPSL;ADKB;ATP6V1E1;LALBA;LASS1;PGM3 |
| Vitamin digestion and absorption | PNLIP;TCN2;CUBN;GIF;MMACHC;LRAT;SLC23A1;SLC5A6;APOB |
FOLH1 has several biochemical functions, for example, Ac-Asp-Glu binding, dipeptidase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOLH1 itself. We selected most functions FOLH1 had, and list some proteins which have the same functions with FOLH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Ac-Asp-Glu binding | |
| dipeptidase activity | FOLH1;SCRN3;NAALADL1;CNDP1;DPEP2;CNDP2;NAALAD2;PEPD;SCRN1 |
| metal ion binding | ZNF649;PNLIP;ENTPD7;RHO;NOB1;BMI1A;AKAP8L;ZFP259;ZNF433 |
| metallocarboxypeptidase activity | CPA6;CPZ;CPB1;CPD;CPB2;AGBL5;CPM;CPO;AEBP1 |
| peptidase activity | ADAMTS4;TMPRSS5;PSMB9B;ELA2L;NAPSA;C6AST1;SOLH;CAPN3B;IHHA |
| tetrahydrofolyl-poly(glutamate) polymer binding |
FOLH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOLH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOLH1.
Dlg4; RPS3; MTAP; MME
- Q&As
- Reviews
Q&As (5)
Ask a questionNew radioligands and imaging agents with enhanced specificity and reduced off-target effects are being developed for more effective treatment.
Targeting FOLH1 helps deliver treatments directly to cancer cells, minimizing damage to healthy tissues, thus improving treatment precision.
Yes, research suggests potential roles in imaging and therapy for other cancers expressing FOLH1, such as renal cell carcinoma and certain types of gliomas.
Yes, FOLH1-based imaging techniques show promise in detecting cancer at early stages, aiding in timely intervention and improved outcomes.
Yes, numerous trials investigate FOLH1-targeted imaging and therapies in various cancers, aiming to expand its clinical utility.
Customer Reviews (3)
Write a reviewIt has been shown to play a crucial role in multiple cellular processes, making it highly valuable for investigations into cell signaling, inflammation, and immune responses.
Incorporating the FOLH1 protein into your research will not only meet but exceed your expectations, enabling you to advance your scientific discoveries with confidence.
Researchers can leverage the unique properties of the FOLH1 protein to gain insights into its biological functions and its impact on disease mechanisms.
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