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  • Official Full Name

    frizzled class receptor 6

  • Overview

    This gene represents a member of the frizzled gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]
  • Synonyms

    FZD6; frizzled class receptor 6; FZ6; FZ-6; HFZ6; NDNC10; frizzled-6; frizzled homolog 6; frizzled family receptor 6; seven transmembrane helix receptor; frizzled 6, seven transmembrane spanning receptor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Gallus gallus (Chicken)
  • Homo sapiens (Human)
  • Human
  • Mus musculus (Mouse)
  • Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • Fc
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FZD6-739H Recombinant Human FZD6 Protein, His-tagged HEK293 His
Human FZD6-738H Recombinant Human FZD6 Protein, Fc-tagged HEK293 Fc
Human FZD6-13069H Recombinant Human FZD6, His-tagged E.coli His 486-706a.a.
Human FZD6-6089HCL Recombinant Human FZD6 293 Cell Lysate HEK293 N/A
Human FZD6-4597H Recombinant Human FZD6 Protein, GST-tagged Wheat Germ GST
Human FZD6-3017H Recombinant Human FZD6 protein, His-tagged E.coli His 27-182 aa
Canis lupus familiaris (Dog) (Canis familiaris) RFL33663CF Recombinant Full Length Dog Frizzled-6(Fzd6) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-712)
Gallus gallus (Chicken) RFL21911GF Recombinant Full Length Chicken Frizzled-6(Fzd6) Protein, His-Tagged E.coli expression system His Full Length (1-190)
Homo sapiens (Human) RFL5021HF Recombinant Full Length Human Frizzled-6(Fzd6) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-706)
Mus musculus (Mouse) RFL8952MF Recombinant Full Length Mouse Frizzled-6(Fzd6) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-709)
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) RFL10293PF Recombinant Full Length Pongo Abelii Frizzled-6(Fzd6) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (20-707)
Rhesus Macaque FZD6-1777R Recombinant Rhesus monkey FZD6 Protein, His-tagged Mammalian Cell His
Rhesus Macaque FZD6-1598R-B Recombinant Rhesus Macaque FZD6 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque FZD6-1598R Recombinant Rhesus Macaque FZD6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish FZD6-10841Z Recombinant Zebrafish FZD6 Mammalian Cell His
Chicken FZD6-4682C Recombinant Chicken FZD6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FZD6 Related Articles
  • FZD6 Related Research Area
  • FZD6 Related Signal Pathway

FZD6 involved in several pathways and played different roles in them. We selected most pathways FZD6 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with FZD6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hippo signaling pathwayCRB2;AREG;NKD1;CRB1;TEAD3;SAV1;NF2;GDF7;FZD7
Signaling pathways regulating pluripotency of stem cellsID3;WNT8A;REST;WNT9A;LHX5;ID2;ACVR2A;FGF2;ESX1
Pathways in cancerRB1;TGFB3;MMP2;BIRC5;GNB4;TRAF3;MAP2K2;TCF7L2;PDGFRB
Proteoglycans in cancerERBB2;VEGFA;RAF1;FZD10;WNT8A;NUDT16L1;BRAF;HPSE;GAB1
Basal cell carcinomaWNT3;WNT6;WNT7B;PTCH1;FZD9;WNT9A;Shh;SUFU;TCF7

FZD6 has several biochemical functions, for example, G-protein coupled receptor activity, Wnt-activated receptor activity, Wnt-protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FZD6 itself. We selected most functions FZD6 had, and list some proteins which have the same functions with FZD6. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled receptor activityGPR45;NPFFR1L1;NPY8BR;V2RX1;TAAR14J;TAS2R107;ADCYAP1R1A;S1PR2;TAAR12G
Wnt-activated receptor activityFZD8B;FZD5;FZD9;FZD3;FZD9B;LRP2A;FZD2;LRP5L;FZD7
ubiquitin protein ligase bindingSCN5A;CASP10;RANGAP1;FANCL;GPI1;MAGEA2B;CUL2;IKBKG;HSPA8

FZD6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FZD6 here. Most of them are supplied by our site. Hope this information will be useful for your research of FZD6.


Akane, H; Saito, F; et al. Gene expression profile of brain regions reflecting aberrations in nervous system development targeting the process of neurite extension of rat offspring exposed developmentally to glycidol. JOURNAL OF APPLIED TOXICOLOGY 34:1389-1399(2014).
Li, XF; Xu, L; et al. Otitis Media in Sperm-Associated Antigen 6 (Spag6)-Deficient Mice. PLOS ONE 9:-(2014).
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