FZD6

  • Official Full Name

    frizzled class receptor 6

  • Overview

    This gene represents a member of the frizzled gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]

  • Synonyms

    FZD6;frizzled class receptor 6;FZ6;FZ-6;HFZ6;NDNC10;frizzled-6;frizzled homolog 6;frizzled family receptor 6;seven transmembrane helix receptor;frizzled 6, seven transmembrane spanning receptor

Recombinant Proteins

  • Human
  • Zebrafish
  • Rhesus macaque
  • Chicken
  • Pongo Abelii
  • Dog
  • Mus musculus
  • E.coli
  • HEK293
  • Mammalian Cells
  • Wheat Germ
  • His
  • Avi
  • Fc
  • Non
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
FZD6-13069H Recombinant Human FZD6, His-tagged E.coli Human His 486-706a.a.
FZD6-739H Recombinant Human FZD6 Protein, His-tagged HEK293 Human His 1-153 a.a.
FZD6-3017H Recombinant Human FZD6 protein, His-tagged E.coli Human His 27-182 aa
FZD6-739HB Recombinant Human FZD6 Protein, His-Avi-tagged, biotinylated Avi&His Met1-Val153
FZD6-10841Z Recombinant Zebrafish FZD6 Mammalian Cells Zebrafish His
FZD6-1777R Recombinant Rhesus monkey FZD6 Protein, His-tagged Mammalian Cells Rhesus macaque His
FZD6-4682C Recombinant Chicken FZD6 Mammalian Cells Chicken His
FZD6-738H Recombinant Human FZD6 Protein, Fc-tagged HEK293 Human Fc 1-153 a.a.
FZD6-6089HCL Recombinant Human FZD6 293 Cell Lysate HEK293 Human Non
FZD6-1598R Recombinant Rhesus Macaque FZD6 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
FZD6-1598R-B Recombinant Rhesus Macaque FZD6 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
FZD6-1673H Recombinant Human FZD6 protein, GST-tagged E.coli Human GST 486-706 aa
FZD6-4597H Recombinant Human FZD6 Protein, GST-tagged Wheat Germ Human GST
RFL10293PF Recombinant Full Length Pongo Abelii Frizzled-6(Fzd6) Protein, His-Tagged E.coli Pongo Abelii His Full L. Full Length of Mature Protein (20-707)
RFL21911GF Recombinant Full Length Chicken Frizzled-6(Fzd6) Protein, His-Tagged E.coli Chicken His Full L. Full Length (1-190)
RFL33663CF Recombinant Full Length Dog Frizzled-6(Fzd6) Protein, His-Tagged E.coli Dog His Full L. Full Length of Mature Protein (19-712)
RFL5021HF Recombinant Full Length Human Frizzled-6(Fzd6) Protein, His-Tagged E.coli Human His Full L. Full Length of Mature Protein (19-706)
RFL8952MF Recombinant Full Length Mouse Frizzled-6(Fzd6) Protein, His-Tagged E.coli Mus musculus His Full L. Full Length of Mature Protein (19-709)

    Involved Pathway

    FZD6 involved in several pathways and played different roles in them. We selected most pathways FZD6 participated on our site, such as Wnt signaling pathway,Hippo signaling pathway,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with FZD6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Proteoglycans in cancer NANOG,TGFB1,Ctsl,TRP53,FN1,TLR4,RPS6KB1,CCND1,WNT5B,ITGB1
    Melanogenesis WNT3,TCF7L1A,CREB3L3L,WNT16,FZD8A,CAMK2D,GNAO1B,Adcy4,ADCY1B,GNAI3
    Basal cell carcinoma GSK3B,STK36,WNT7B,GLI1,SMO,APC,AXIN2,FZD8,TRP53,WNT3
    Signaling pathways regulating pluripotency of stem cells MAPK1,KLF4,BMI1,MAP2K1,WNT3,PCGF3,WNT2B,POU5F1,MAP2K2,INHBE
    Wnt signaling pathway WNT11,RAC3A,WIF1,AXIN1,PRKACBA,CUL1B,LRP5,SFRP1,CER1,PRKACA
    Pathways in cancer TGFB1,TCF7,MMP2,BMP4,Adcy4,PGF,TRAF6,TFG,CUL2,FLT3
    HTLV-I infection VCAM1,FZD1,VDAC3,HLA-DRA,HLA-DRB3,HLA-B,POLE4,CD3G,STAT5A,PTTG1
    Hippo signaling pathway PPP2CA,PARD6A,TEAD4,DLG3,BMP5,TEAD1,CCND1,SOX2,DVL3,AJUBA

    Protein Function

    FZD6 has several biochemical functions, for example, G-protein coupled receptor activity,Wnt-activated receptor activity,Wnt-protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FZD6 itself. We selected most functions FZD6 had, and list some proteins which have the same functions with FZD6. You can find most of the proteins on our site.

    Function Related Protein
    ubiquitin protein ligase binding RIPK1,UBXN6,UCHL1,EGFR,RNF20,UQCRC1,TANK,USP13,HSPA1B,ERLIN2
    Wnt-activated receptor activity FZD8B,FZD8,FZD7B,LRP2A,Fzd4,FZD8A,FZD1,LRP5,FZD3B,LRP6
    protein binding EN1,ARL2BP,KRTAP9-4,NDUFAF3,SEPT6,C1QTNF2,NUP85,MAP2K7,MFN2,TSC22D3
    G-protein coupled receptor activity TAAR8A,DRD4-RS,MRGPRA5,FFAR3,TAAR10A,MTNR1C,VMN1R46,TAAR12F,TAAR12E,GPR20
    Wnt-protein binding Fzd4,FZD3A,SFRP2,SFRP1B,FZD9,FZD9B,ROR2,FZD8B,PORCN,WLS

    Interacting Protein

    FZD6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FZD6 here. Most of them are supplied by our site. Hope this information will be useful for your research of FZD6.

    SFRP1

    FZD6 Related Signal Pathway

    Resources

    Gene Families

    GPCRs Class F

    Research Area

    Frizzled Receptors
    Wnt Receptors

    References

    • Akane, H; Saito, F; et al. Gene expression profile of brain regions reflecting aberrations in nervous system development targeting the process of neurite extension of rat offspring exposed developmentally to glycidol. JOURNAL OF APPLIED TOXICOLOGY 34:1389-1399(2014).
    • Li, XF; Xu, L; et al. Otitis Media in Sperm-Associated Antigen 6 (Spag6)-Deficient Mice. PLOS ONE 9:-(2014).

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