FZD6
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Official Full Name
frizzled class receptor 6
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Overview
This gene represents a member of the frizzled gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011] -
Synonyms
FZD6; frizzled class receptor 6; FZ6; FZ-6; HFZ6; NDNC10; frizzled-6; frizzled homolog 6; frizzled family receptor 6; seven transmembrane helix receptor; frizzled 6, seven transmembrane spanning receptor;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Canis lupus familiaris (Dog) (Canis familiaris)
- Chicken
- Gallus gallus (Chicken)
- Homo sapiens (Human)
- Human
- Mus musculus (Mouse)
- Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
- Rhesus Macaque
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- Mammalian Cell
- Wheat Germ
- Fc
- GST
- His
- Avi
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | FZD6-739H | Recombinant Human FZD6 Protein, His-tagged | HEK293 | His | Met1-Val153 |
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| Human | FZD6-738H | Recombinant Human FZD6 Protein, Fc-tagged | HEK293 | Fc | Met1-Val153 |
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| Human | FZD6-13069H | Recombinant Human FZD6, His-tagged | E.coli | His | 486-706a.a. | |
| Human | FZD6-6089HCL | Recombinant Human FZD6 293 Cell Lysate | HEK293 | Non |
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| Human | FZD6-4597H | Recombinant Human FZD6 Protein, GST-tagged | Wheat Germ | GST |
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| Human | FZD6-3017H | Recombinant Human FZD6 protein, His-tagged | E.coli | His | 27-182 aa | |
| Canis lupus familiaris (Dog) (Canis familiaris) | RFL33663CF | Recombinant Full Length Dog Frizzled-6(Fzd6) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (19-712) |
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| Gallus gallus (Chicken) | RFL21911GF | Recombinant Full Length Chicken Frizzled-6(Fzd6) Protein, His-Tagged | E.coli expression system | His | Full Length (1-190) |
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| Homo sapiens (Human) | RFL5021HF | Recombinant Full Length Human Frizzled-6(Fzd6) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (19-706) |
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| Mus musculus (Mouse) | RFL8952MF | Recombinant Full Length Mouse Frizzled-6(Fzd6) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (19-709) |
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| Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) | RFL10293PF | Recombinant Full Length Pongo Abelii Frizzled-6(Fzd6) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (20-707) |
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| Rhesus Macaque | FZD6-1777R | Recombinant Rhesus monkey FZD6 Protein, His-tagged | Mammalian Cell | His |
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| Rhesus Macaque | FZD6-1598R-B | Recombinant Rhesus Macaque FZD6 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rhesus Macaque | FZD6-1598R | Recombinant Rhesus Macaque FZD6 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Zebrafish | FZD6-10841Z | Recombinant Zebrafish FZD6 | Mammalian Cell | His |
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| Chicken | FZD6-4682C | Recombinant Chicken FZD6 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- FZD6 Related Signal Pathway
FZD6 involved in several pathways and played different roles in them. We selected most pathways FZD6 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with FZD6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | CAMK2D2;RAC3;PPP3CB;WNT2BB;PPARDB;WNT5A;DKK4;TBL1XR1;RAC3A |
| Hippo signaling pathway | FZD2;SNAI2;LATS1;YWHAB;BMP2;FZD5;FZD8;ITGB2;WNT9A |
| Signaling pathways regulating pluripotency of stem cells | ID1;SMAD3;HAND1;IGF1R;WNT1;INHBA;SMAD5;WNT2;SETDB1 |
| Melanogenesis | EDNRB2;Kitl;POMC;PRKACBA;MITFA;FZD9;PRKACA;PLCB3;FZD8B |
| HTLV-I infection | MAP3K14;NFATC4;PPP3CB;PPP3CC;TBP;ATM;WNT9A;ICAM1;ITGAL |
| Pathways in cancer | RHOA;PTCH2;WNT7A;SMAD2;PRKCB;LPAR6;BIRC2;CXCL12;AKT2 |
| Proteoglycans in cancer | MDM2;THBS1;MTOR;PIK3CB;FAS;TFAP4;GRB2;WNT1;RDX |
| Basal cell carcinoma | WNT8A;WNT3A;WNT8B;FZD8;FZD1;WNT3;TCF7;LEF1;WNT11 |
FZD6 has several biochemical functions, for example, G-protein coupled receptor activity, Wnt-activated receptor activity, Wnt-protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FZD6 itself. We selected most functions FZD6 had, and list some proteins which have the same functions with FZD6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | DRD2B;GPR146;P2RY6;TMTOPS3A;APLNR;RGRB;GPR39;RXFP2B;PPYR1 |
| Wnt-activated receptor activity | FZD7A;FZD9;Fzd4;LRP5L;FZD7;FZD8A;FZD3;FZD5;LRP6 |
| Wnt-protein binding | FZD3B;SFRP4;FZD5;GPR177;SFRP1B;SETD6;SFRP1;FZD8A;LRP6 |
| protein binding | CD97;CCL11;MYLIPA;SLC6A3;ELANE;ORC3L;BANF1;RAB39A;SCAND1 |
| ubiquitin protein ligase binding | PRR5L;BECN1;ZFP746;CUL3A;FOXO1;TRIM37;HSPA8;LYN;PRKACB |
FZD6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FZD6 here. Most of them are supplied by our site. Hope this information will be useful for your research of FZD6.
SFRP1
Research Area
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