• Official Full Name

    gamma-aminobutyric acid (GABA) B receptor, 1

  • Background

    Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA;exerts its effects through ionotropic (GABA(A/C)) receptors, to produce fast synaptic inhibition, and metabotropic;(GABA(B)) receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of;two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is;mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple;sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene;generates multiple transcript variants.
  • Synonyms

    GABBR1; gamma-aminobutyric acid (GABA) B receptor, 1; gamma-aminobutyric acid type B receptor subunit 1; GABA B receptor; GPRC3A; hGB1a; FLJ92613; GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABAB R1; GABAB subunit 1c; GABABR1; GABR1_HUMAN; Gamma aminobutyric acid (GABA) B receptor 1; Gb1; GABAB, subunit 1c; seven transmembrane helix receptor; GABBR1-3; dJ271M21.1.1; dJ271M21.1.2;
    • Type:
    • Cell & Tissue Lysates
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • Flag
    • His|T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GABBR1-6073HCL Recombinant Human GABBR1 293 Cell Lysate HEK293 N/A
    Human GABBR1-28091TH Recombinant Human GABBR1 Wheat Germ N/A
    Human GABBR1-1116HFL Recombinant Human GABBR1 protein, His&Flag-tagged HEK293 His&Flag
    Human GABBR1-8161H Recombinant Human GABBR1 protein, His & T7-tagged E.coli His/T7
    Human GABBR1-4627H Recombinant Human GABBR1 Protein, GST-tagged Wheat Germ GST
    Mouse GABBR1-3424M Recombinant Mouse GABBR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse GABBR1-3424M-B Recombinant Mouse GABBR1 Protein Pre-coupled Magnetic Beads HEK293
    Mouse GABBR1-6141M Recombinant Mouse GABBR1 Protein Mammalian Cell His
    Rhesus Macaque GABBR1-1789R Recombinant Rhesus monkey GABBR1 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque GABBR1-1610R Recombinant Rhesus Macaque GABBR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque GABBR1-1610R-B Recombinant Rhesus Macaque GABBR1 Protein Pre-coupled Magnetic Beads HEK293
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • GABBR1 Related Articles
    • GABBR1 Related Research Area

    GABBR1 involved in several pathways and played different roles in them. We selected most pathways GABBR1 participated on our site, such as cAMP signaling pathway, Neuroactive ligand-receptor interaction, GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GABBR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cAMP signaling pathwayPIK3R3;TNNI3;PRKACA;VIPR2;PIK3R2;NPY1R;MAPK1;HTR6;MLLT4
    Neuroactive ligand-receptor interactionNPY8BR;LPAR6A;DRD2B;GRM7;GRIA1;S1PR5A;TAAR14D;MLNR;NPY8AR
    Estrogen signaling pathwayESR2;PRKACA;SRC;CREB3L2;SOS1;NOS3;PRKCD;HSPA1A;FKBP5

    GABBR1 has several biochemical functions, for example, G-protein coupled GABA receptor activity, contributes_to G-protein coupled GABA receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GABBR1 itself. We selected most functions GABBR1 had, and list some proteins which have the same functions with GABBR1. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled GABA receptor activityGPR156;GABBR1
    contributes_to G-protein coupled GABA receptor activityGABBR2;GABBR1

    GABBR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GABBR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GABBR1.


    Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
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