GABBR1

  • Official Full Name

    gamma-aminobutyric acid (GABA) B receptor, 1

  • Overview

    Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA;exerts its effects through ionotropic (GABA(A/C)) receptors, to produce fast synaptic inhibition, and metabotropic;(GABA(B)) receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of;two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is;mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple;sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene;generates multiple transcript variants.

  • Synonyms

    GABBR1;gamma-aminobutyric acid (GABA) B receptor, 1;gamma-aminobutyric acid type B receptor subunit 1;GABA B receptor;GPRC3A;hGB1a;FLJ92613;GABA-B receptor 1;GABA-B-R1;GABA-BR1;GABAB R1;GABAB subunit 1c;GABABR1;GABR1_HUMAN;Gamma aminobutyric acid (GABA) B receptor 1;Gb1;GABAB, subunit 1c;seven transmembrane helix receptor;GABBR1-3;dJ271M21.1.1;dJ271M21.1.2

Recombinant Proteins

  • Rhesus macaque
  • Human
  • Mouse
  • Mammalian Cells
  • Wheat Germ
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • His
  • Non
  • T7
  • Flag
  • Avi
  • Fc
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
GABBR1-1789R Recombinant Rhesus monkey GABBR1 Protein, His-tagged Mammalian Cells Rhesus macaque His
GABBR1-28091TH Recombinant Human GABBR1 Wheat Germ Human Non 100 amino acids
GABBR1-6141M Recombinant Mouse GABBR1 Protein Mammalian Cells Mouse His
GABBR1-8161H Recombinant Human GABBR1 protein, His & T7-tagged E.coli Human His&T7 Val199~Gly570
GABBR1-6073HCL Recombinant Human GABBR1 293 Cell Lysate HEK293 Human Non
GABBR1-1116HFL Recombinant Human GABBR1 protein, His&Flag-tagged HEK293 Human Flag&His 1-961 aa
GABBR1-1610R Recombinant Rhesus Macaque GABBR1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
GABBR1-1610R-B Recombinant Rhesus Macaque GABBR1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
GABBR1-3424M Recombinant Mouse GABBR1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
GABBR1-3424M-B Recombinant Mouse GABBR1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
GABBR1-4627H Recombinant Human GABBR1 Protein, GST-tagged Wheat Germ Human GST
GABBR1-5162HF Recombinant Full Length Human GABBR1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 844 amino acids

    Involved Pathway

    GABBR1 involved in several pathways and played different roles in them. We selected most pathways GABBR1 participated on our site, such as cAMP signaling pathway,Neuroactive ligand-receptor interaction,GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GABBR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cAMP signaling pathway RAF1,MAP2K2,HTR6,CREB3L3,HCAR3,CREB5,GRIN2C,PIK3R1,PAK1,CAMK2B
    Neuroactive ligand-receptor interaction GRIA2B,ADRA1BB,GABRR3,GLRA2,TAAR14A,CHRNA2A,RXFP3,PTH2R,CHRNA9,TAAR10C
    GABAergic synapse GNAI3,GABRA3,HAP1,GNAI2,SLC12A5,GABRP,GLS2,GABRR1,GABRG2,PRKCA
    Estrogen signaling pathway PIK3R3,AKT1,GNAO1,SHC2,PLCB1,GABBR2,CALM1,ESR2,PIK3CG,GNAQ

    Protein Function

    GABBR1 has several biochemical functions, for example, G-protein coupled GABA receptor activity,contributes_to G-protein coupled GABA receptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GABBR1 itself. We selected most functions GABBR1 had, and list some proteins which have the same functions with GABBR1. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled GABA receptor activity GPR156
    contributes_to G-protein coupled GABA receptor activity GABBR2
    protein binding ADCYAP1,RHOB,GOLGA2,LANCL2,RPL23,EMD,RNF41,PHAX,DSCC1,ZNF136

    Interacting Protein

    GABBR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GABBR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GABBR1.

    GABBR2;NSF;MAX;ABL1;FYN;NCK1;PIK3R1;CRK;GRB2;CHFR;ALB

    Resources

    Gene Families

    What is GPCR

    Research Area

    Osteoclast Markers
    GABA Receptors
    Osteoblast and Osteoclast Markers

    References

    • Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).

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