GABBR1

  • Official Full Name

    gamma-aminobutyric acid (GABA) B receptor, 1

  • Overview

    Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA;exerts its effects through ionotropic (GABA(A/C)) receptors, to produce fast synaptic inhibition, and metabotropic;(GABA(B)) receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of;two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is;mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple;sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene;generates multiple transcript variants.
  • Synonyms

    GABBR1; gamma-aminobutyric acid (GABA) B receptor, 1; gamma-aminobutyric acid type B receptor subunit 1; GABA B receptor; GPRC3A; hGB1a; FLJ92613; GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABAB R1; GABAB subunit 1c; GABABR1; GABR1_HUMAN; Gamma aminobutyric acid (GABA) B receptor 1; Gb1; GABAB, subunit 1c; seven transmembrane helix receptor; GABBR1-3; dJ271M21.1.1; dJ271M21.1.2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Flag
  • His|T7
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GABBR1-28091TH Recombinant Human GABBR1 Wheat Germ N/A 100 amino acids
Human GABBR1-8161H Recombinant Human GABBR1 protein, His & T7-tagged E.coli His/T7 Val199~Gly570 (Accession# Q9UBS5)
Human GABBR1-6073HCL Recombinant Human GABBR1 293 Cell Lysate HEK293 N/A
Human GABBR1-4627H Recombinant Human GABBR1 Protein, GST-tagged Wheat Germ GST
Human GABBR1-1116HFL Recombinant Human GABBR1 protein, His&Flag-tagged HEK293 His&Flag 1-961 aa
Human GABBR1-5162HF Recombinant Full Length Human GABBR1 Protein, GST-tagged In Vitro Cell Free System GST 844 amino acids
Mouse GABBR1-6141M Recombinant Mouse GABBR1 Protein Mammalian Cell His
Mouse GABBR1-3424M-B Recombinant Mouse GABBR1 Protein Pre-coupled Magnetic Beads HEK293
Mouse GABBR1-3424M Recombinant Mouse GABBR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque GABBR1-1789R Recombinant Rhesus monkey GABBR1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque GABBR1-1610R Recombinant Rhesus Macaque GABBR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque GABBR1-1610R-B Recombinant Rhesus Macaque GABBR1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

GABBR1 involved in several pathways and played different roles in them. We selected most pathways GABBR1 participated on our site, such as cAMP signaling pathway, Neuroactive ligand-receptor interaction, GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GABBR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
cAMP signaling pathwayCALM1;GABBR1;GPR119;PLD2;PRKACB;ATP1A3;CREB3L3;HTR1B;TSHR
Neuroactive ligand-receptor interactionGRIN1B;TRHRB;CHRNB2;GABRA2;GRID2;LHCGR;RXFP4;TAAR12C;GLRB
GABAergic synapseGNG10;GNB4;SLC6A1;GABBR2;GABRR3;GNAI3;PRKCA;GABRB1;GLUL
Estrogen signaling pathwayKCNJ6;ATF4;CREB5;FKBP4;ESR1;PIK3CG;NOS3;HSPA1B;SP1

GABBR1 has several biochemical functions, for example, G-protein coupled GABA receptor activity, contributes_to G-protein coupled GABA receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GABBR1 itself. We selected most functions GABBR1 had, and list some proteins which have the same functions with GABBR1. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled GABA receptor activityGABBR1;GPR156
contributes_to G-protein coupled GABA receptor activityGABBR2;GABBR1
protein bindingGRIN1;PSRC1;HCFC1;UPRT;ERCC3;ZC3H8;XPO1;TTLL6;RBM14

GABBR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GABBR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GABBR1.

GABBR2; NSF; MAX; ABL1; FYN; NCK1; PIK3R1; CRK; GRB2; CHFR; ALB

Research Area

Related articles

Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
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