GABBR1
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Official Full Name
gamma-aminobutyric acid (GABA) B receptor, 1
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Background
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA;exerts its effects through ionotropic (GABA(A/C)) receptors, to produce fast synaptic inhibition, and metabotropic;(GABA(B)) receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of;two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is;mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple;sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene;generates multiple transcript variants. -
Synonyms
GABBR1; gamma-aminobutyric acid (GABA) B receptor, 1; gamma-aminobutyric acid type B receptor subunit 1; GABA B receptor; GPRC3A; hGB1a; FLJ92613; GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABAB R1; GABAB subunit 1c; GABABR1; GABR1_HUMAN; Gamma aminobutyric acid (GABA) B receptor 1; Gb1; GABAB, subunit 1c; seven transmembrane helix receptor; GABBR1-3; dJ271M21.1.1; dJ271M21.1.2;
- Involved Pathway
- Protein Function
- Interacting Protein
- GABBR1 Related Articles
- GABBR1 Related Research Area
GABBR1 involved in several pathways and played different roles in them. We selected most pathways GABBR1 participated on our site, such as cAMP signaling pathway, Neuroactive ligand-receptor interaction, GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GABBR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cAMP signaling pathway | PIK3R3;TNNI3;PRKACA;VIPR2;PIK3R2;NPY1R;MAPK1;HTR6;MLLT4 |
| Neuroactive ligand-receptor interaction | NPY8BR;LPAR6A;DRD2B;GRM7;GRIA1;S1PR5A;TAAR14D;MLNR;NPY8AR |
| GABAergic synapse | GNB4;GNAI1;GNGT2;SLC38A3;GABRB3;PRKACB;GABRG3;GABRA6;PRKCG |
| Estrogen signaling pathway | ESR2;PRKACA;SRC;CREB3L2;SOS1;NOS3;PRKCD;HSPA1A;FKBP5 |
GABBR1 has several biochemical functions, for example, G-protein coupled GABA receptor activity, contributes_to G-protein coupled GABA receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GABBR1 itself. We selected most functions GABBR1 had, and list some proteins which have the same functions with GABBR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled GABA receptor activity | GPR156;GABBR1 |
| contributes_to G-protein coupled GABA receptor activity | GABBR2;GABBR1 |
| protein binding | STXBP3;PEX5;ORC3L;SCYL1;FCHSD2;APOO;JPH2;FGFR1;BANF1 |
GABBR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GABBR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GABBR1.
GABBR2; NSF; MAX; ABL1; FYN; NCK1; PIK3R1; CRK; GRB2; CHFR; ALB
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