GHSR

  • Official Full Name

    growth hormone secretagogue receptor

  • Overview

    This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.
  • Synonyms

    GHSR; growth hormone secretagogue receptor; growth hormone secretagogue receptor type 1; GH releasing peptide receptor; GH-releasing peptide receptor; Ghrelin receptor; GHRP; GHRPR; GHS-R; GHSR_HUMAN; Growth hormone secretagogue receptor 1; growth hormone secretatgogue receptor;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mus musculus (Mouse)
  • Mustela putorius furo (European domestic ferret) (Mustela furo)
  • Oryctolagus cuniculus (Rabbit)
  • Rat
  • Rattus norvegicus (Rat)
  • Sus scrofa (Pig)
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Flag
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GHSR-29024TH Recombinant Human GHSR Wheat Germ N/A 289 amino acids
Human GHSR-1043HFL Recombinant Human GHSR protein, His&Flag-tagged HEK293 His&Flag 1-289 aa
Human GHSR-4895H Recombinant Human GHSR Protein, GST-tagged Wheat Germ GST
Human GHSR-197HF Recombinant Full Length Human GHSR Protein In Vitro Cell Free System 289 amino acids
Human GHSR-1578H Recombinant Human GHSR Protein, His&GST-tagged E.coli N-His&GST Met1-Arg70
Human GHSR-5254HF Recombinant Full Length Human GHSR Protein, GST-tagged In Vitro Cell Free System GST 289 amino acids
Human GHSR-3244H Recombinant Human GHSR Protein (Met1-Arg70), N-GST tagged E.coli N-GST Met1-Arg70
Rat GHSR-2532R Recombinant Rat GHSR Protein Mammalian Cell His
Rat GHSR-2188R-B Recombinant Rat GHSR Protein Pre-coupled Magnetic Beads HEK293
Rat GHSR-2188R Recombinant Rat GHSR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL12638HF Recombinant Full Length Human Growth Hormone Secretagogue Receptor Type 1(Ghsr) Protein, His-Tagged E.coli expression system His Full Length (1-366)
Mus musculus (Mouse) RFL17486MF Recombinant Full Length Mouse Growth Hormone Secretagogue Receptor Type 1(Ghsr) Protein, His-Tagged E.coli expression system His Full Length (1-364)
Mustela putorius furo (European domestic ferret) (Mustela furo) RFL9735MF Recombinant Full Length Mustela Putorius Furo Growth Hormone Secretagogue Receptor Type 1(Ghsr) Protein, His-Tagged E.coli expression system His Full Length (1-366)
Oryctolagus cuniculus (Rabbit) RFL2283OF Recombinant Full Length Rabbit Growth Hormone Secretagogue Receptor Type 1(Ghsr) Protein, His-Tagged E.coli expression system His Full Length (1-366)
Rattus norvegicus (Rat) RFL6718RF Recombinant Full Length Rat Growth Hormone Secretagogue Receptor Type 1(Ghsr) Protein, His-Tagged E.coli expression system His Full Length (1-364)
Sus scrofa (Pig) RFL32854SF Recombinant Full Length Pig Growth Hormone Secretagogue Receptor Type 1(Ghsr) Protein, His-Tagged E.coli expression system His Full Length (1-366)
Chicken GHSR-5964C Recombinant Chicken GHSR Mammalian Cell His
Kit-0904 TR-FRET PXR (SXR) Competitive Binding Assay Kit, goat N/A
Kit-1255 GHSR U2OS β-Arrestin-1 GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

GHSR involved in several pathways and played different roles in them. We selected most pathways GHSR participated on our site, such as cAMP signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GHSR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
cAMP signaling pathwayROCK2;GRIA1;AKT2;CAMK2A;CNGA1;PIK3R5;MAP2K2;ATP2B4;VAV1
Neuroactive ligand-receptor interactionNPFFR2;P2RX2;PRLR;CHRNB3B;P2RX3B;MTNR1AA;GRIK5;THRA;TRHR2

GHSR has several biochemical functions, for example, G-protein coupled receptor activity, growth hormone secretagogue receptor activity, growth hormone-releasing hormone receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GHSR itself. We selected most functions GHSR had, and list some proteins which have the same functions with GHSR. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled receptor activityCD97;TAS2R130;FZD3A;TRHRB;RGRB;TAS2R129;PTGDR2;OR12D3;OLFR5
growth hormone secretagogue receptor activity
growth hormone-releasing hormone receptor activityGHSR;GHRHRA;GHRHR;GHSRA;MLNR
peptide hormone bindingACVR1;GALR2;AVPR1A;MC3R;RXFP2;PTH1RB;GHSR;SLC40A1;GALR1

GHSR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GHSR here. Most of them are supplied by our site. Hope this information will be useful for your research of GHSR.

Gene Family

GPCRs

Research Area

Related articles

Mani, BK; Walker, AK; et al. Neuroanatomical Characterization of a Growth Hormone Secretagogue Receptor-Green Fluorescent Protein Reporter Mouse. JOURNAL OF COMPARATIVE NEUROLOGY 522:3644-3666(2014).
Niarami, MD; Masoudi, AA; et al. ASSOCIATION OF SINGLE NUCLEOTIDE POLYMORPHISM OF GHSR AND TGFB2 GENES WITH GROWTH AND BODY COMPOSITION TRAITS IN SIRE AND DAM LINES OF A BROILER CHICKEN. ANIMAL BIOTECHNOLOGY 25:13-22(2014).
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