GLI1

  • Official Full Name

    GLI family zinc finger 1
  • Overview

    GLI was first identified as a gene amplified in a malignant glioma capable of transforming primary cells in cooperation with adenovirus E1A. GLI belongs to the Kruppel family of zinc finger proteins that includes three mammalian GLI proteins: GLI1, GLI2
  • Synonyms

    GLI1;GLI family zinc finger 1;GLI, glioma associated oncogene family zinc finger 1 , glioma associated oncogene homolog 1 (zinc finger protein);zinc finger protein GLI1;oncogene GLI;glioma-associated oncogene 1;glioma-associated oncogene homolog 1

Recombinant Proteins

  • Human
  • Rat
  • Mouse
  • Zebrafish
  • HEK293
  • E.coli
  • Insect Cells
  • Mammalian Cells
  • Wheat Germ
  • DDK
  • Myc
  • His
  • T7
  • GST
  • Non
  • Avi
  • Fc
  • Flag
  • pstS1
Cat.# Product name Source (Host) Species Tag Protein Length Price
GLI1-312H Recombinant Human GLI1 protein, MYC/DDK-tagged HEK293 Human DDK&Myc
Gli1-139R Recombinant Rat Gli1 protein, His-tagged E.coli Rat His&T7 810-1109 a.a.
GLI1-158H Recombinant Human GLI1 protein, GST-tagged E.coli Human GST 800-849 a.a.
GLI1-3146H Recombinant Human GLI1 protein, His-tagged E.coli Human His 470-659 aa
GLI1-313H Recombinant Human GLI1 protein E.coli Human Non
GLI1-6401M Recombinant Full Length Mouse GLI1 Protein, His tagged Insect Cells Mouse His Full L.
GLI1-9592Z Recombinant Zebrafish GLI1 Mammalian Cells Zebrafish His
GLI1-5905HCL Recombinant Human GLI1 293 Cell Lysate HEK293 Human Non
GLI1-1254H Recombinant Human GLI1 Protein (921-1106 aa), His-tagged E.coli Human His 921-1106 aa
GLI1-2807H Recombinant Human GLI1 Protein (Phe2-Glu234), N-His tagged E.coli Human His Phe2-Glu234
Gli1-3224M Recombinant Mouse Gli1 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
GLI1-3594M Recombinant Mouse GLI1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
GLI1-3594M-B Recombinant Mouse GLI1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
GLI1-4131HFL Recombinant Full Length Human GLI1 protein, Flag-tagged Mammalian Cells Human Flag Full L.
GLI1-4954H Recombinant Human GLI1 Protein, GST-tagged Wheat Germ Human GST
GLI1-4955H Recombinant Human GLI1 Protein, GST/pstS1-tagged Wheat Germ Human GST&pstS1 401-500 a.a.
GLI1-598H Recombinant Human GLI1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc

    Involved Pathway

    GLI1 involved in several pathways and played different roles in them. We selected most pathways GLI1 participated on our site, such as cAMP signaling pathway,Hedgehog signaling pathway,Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Basal cell carcinoma PTCH1,Fzd4,BMP4,FZD1,TCF7,WNT1,AXIN1,FZD2,DVL2,HHIP
    Hedgehog signaling pathway WNT3,SKI,WNT11B,WNT5A,DHH,WNT2BB,SHHB,WNT11,WNT2,WNT9B
    cAMP signaling pathway PDE4A,NPY,ATP1B2,HTR1B,OXTR,GRIN2C,NFATC1,PDE4C,MAPK3,FSHR
    Pathways in cancer NKX3,FZD5,KIT,LPAR6,WNT5A,FGF14,ERBB2,STAT5B,TCF7,FGF2

    Protein Function

    GLI1 has several biochemical functions, for example, DNA binding,chromatin binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLI1 itself. We selected most functions GLI1 had, and list some proteins which have the same functions with GLI1. You can find most of the proteins on our site.

    Function Related Protein
    microtubule binding MAPRE3A,MAPRE1B,MAPRE1A,NDE1,KLC3,KIF3A,CAMSAP1,MAP6,KIF21A,KIF23
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding OLIG2,SNAI2,TLE4,RELA,ATF1,USF1,POU3F1,USF2,SOX17,PURA
    sequence-specific DNA binding NR2F6A,HOXB8A,FOXJ1A,SIX4B,NKX1-2,HLFB,SALL2,SPIC,ZIC3,FOXQ1
    transcription regulatory region DNA binding SOX17,MZF1,BRD7,FOXA2,ATMIN,MTERFD3,ETV5,NFE2L2,NFKB1,TAF7L
    metal ion binding DDHD2,STAMBPA,Itgam&Itgb2,RNF34A,OAS1,KCNMA1,ZNF319,BMPR2,ZNF7,ZNF521
    chromatin binding TAL1,RNF168,YBX1,HMG20A,CUX1,ELK4,CITED1,FOXC1A,SP140L,HDAC7
    DNA binding ZFP11,ZNF423,EME2,FOXP1B,ZNF572,NUSAP1,HOXB1B,DNASE1L2,GTF2F2A,PURG
    protein binding ING2,CPEB3,TYR,NUFIP1,ATXN7L1,TRIM74,RIPK2,HIST2H3C2,BEX2,KITLG

    Interacting Protein

    GLI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GLI1.

    SUFU

    Resources

    References

    • De Luca, A; Parmigiani, E; et al. Exogenous Sonic Hedgehog Modulates the Pool of GABAergic Interneurons During Cerebellar Development. CEREBELLUM 14:72-85(2015).
    • Nakamura, T; Naruse, M; et al. Novel Hedgehog Agonists Promote Osteoblast Differentiation in Mesenchymal Stem Cells. JOURNAL OF CELLULAR PHYSIOLOGY 230:922-929(2015).

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