GLI1
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Official Full Name
GLI family zinc finger 1 -
Overview
GLI was first identified as a gene amplified in a malignant glioma capable of transforming primary cells in cooperation with adenovirus E1A. GLI belongs to the Kruppel family of zinc finger proteins that includes three mammalian GLI proteins: GLI1, GLI2 -
Synonyms
GLI1;GLI family zinc finger 1;GLI, glioma associated oncogene family zinc finger 1 , glioma associated oncogene homolog 1 (zinc finger protein);zinc finger protein GLI1;oncogene GLI;glioma-associated oncogene 1;glioma-associated oncogene homolog 1
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- HEK293
- E.coli
- Insect Cells
- Mammalian Cells
- Wheat Germ
- DDK
- Myc
- His
- T7
- GST
- Non
- Avi
- Fc
- Flag
- pstS1
Involved Pathway
GLI1 involved in several pathways and played different roles in them. We selected most pathways GLI1 participated on our site, such as cAMP signaling pathway,Hedgehog signaling pathway,Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Basal cell carcinoma | SUFU,WNT9B,SETD6,TCF7,GSK3B,AXIN1,SMO,WNT7A,FZD10,DVL2 |
| cAMP signaling pathway | CNGA2,CAMK4,SUCNR1,VAV2,CREB5,RAC1,CALM2,TNNI3,CALM3,FSHB |
| Hedgehog signaling pathway | DYRK1A,WNT8A,IHHA,GLI2A,GSK3B,GAS1A,WNT2,GLI3,PRKACBA,PRKACAB |
| Pathways in cancer | KITLG,CASP9,BDKRB2,RALGDS,Casp3,ARAF,WNT11,TGFBR2,RASSF5,WNT3 |
Protein Function
GLI1 has several biochemical functions, for example, DNA binding,chromatin binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLI1 itself. We selected most functions GLI1 had, and list some proteins which have the same functions with GLI1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | MAFBB,TBX3,NR1D2B,PPARAA,NR0B1,MNX1,NFE2L1B,IKZF1,HOXB13,ENG1A |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | TLE4,POU4F1,SOX7,MITF,USF2,SFPI1,NFIX,NR5A1,FOXF2A,CIR1 |
| metal ion binding | ZNF726,MUS81,COL27A1,ELMSAN1A,ANKIB1A,KDM5BB,ZNF227,NPTX2,ZHX1,ZC3H11A |
| DNA binding | SMG6,PBX1B,NUP153,TFDP1,FBXL19,MTERFD1,SMAD5,ZFP687,PURG,RORAB |
| transcription regulatory region DNA binding | ZFHX3,FOXM1,EGR2,MTERFD3,CITED1,H2AFY,PAX2,ETV5,PRDM5,CDK5RAP2 |
| protein binding | CST3,TNFRSF11A,MYOCD,C9orf100,TEX19.1,MAP2K7,CTSB,EPM2A,PROC,UBXN2B |
| microtubule binding | PAFAH1B1A,KIFC1,CENPE,CAMSAP1A,KIF22,EML2,MAPRE3B,MAPRE2,CHD4,NDEL1A |
| chromatin binding | PYGO2,SOX10,NKX6-1,POU2F1,NUP62,SMARCA2,NSD1,CREB3,PRKAA2,TTC5 |
Interacting Protein
GLI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GLI1.
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References
- De Luca, A; Parmigiani, E; et al. Exogenous Sonic Hedgehog Modulates the Pool of GABAergic Interneurons During Cerebellar Development. CEREBELLUM 14:72-85(2015).
- Nakamura, T; Naruse, M; et al. Novel Hedgehog Agonists Promote Osteoblast Differentiation in Mesenchymal Stem Cells. JOURNAL OF CELLULAR PHYSIOLOGY 230:922-929(2015).
