GNA11
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Official Full Name
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) [ Homo sapiens ] -
Overview
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alternatively spliced transcript variants encoding the same isoform have been described. -
Synonyms
guanine nucleotide binding protein (G protein), alpha 11 (Gq class);4379;Ensembl:ENSG00000088256;guanine nucleotide-binding protein subunit alpha-11;g alpha-11;G-protein subunit alpha-11;guanine nucleotide-binding protein, Gq class, GNA11;guanine nucleotide-binding protein G(y) subunit alpha;GNA-11
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Flag
- Avi
- Fc
- DDK
- Myc
Involved Pathway
GNA11 involved in several pathways and played different roles in them. We selected most pathways GNA11 participated on our site, such as Calcium signaling pathway,cGMP-PKG signaling pathway,Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNA11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Long-term depression | LYN,PRKCB,PLCB4,PLA2G4D,BRAF,PRKCA,PLA2G4C,PRKG2,IGF1R,PLCB3 |
| Gap junction | PRKACA,PRKACAB,TUBB2A,GNAI3,PRKCBB,PDGFA,PRKG1,MAP2K2B,GUCY1A3,TUBA3C |
| Aldosterone synthesis and secretion | ATF2,CREB5,PLCB4,AGTR1B,KCNK9,LIPE,CAMK2B,CREB3L1,PLCB1,CAMK2A |
| cGMP-PKG signaling pathway | ROCK2,INSR,CREB5,SLC25A31,PLN,SLC25A4,MEF2C,Adcy4,NFATC1,CALM4 |
| Chagas disease (American trypanosomiasis) | MAPK8,MAPK9,CCL2,GNAL,PIK3R1,PIK3CG,TLR4,TICAM1,PPP2R1A,GNAS |
| Calcium signaling pathway | HTR2A,ORAI1,AVPR1B,CALM2,ADRA1B,ATP2A3,PRKCB,CHRM2,CYSLTR1,DRD1B |
| Pathways in cancer | RASSF1,BCL2L1,CASP8,ARAF,MECOM,NFKB1,SKP2,CCND1,LAMB3,CCNA1 |
| Cholinergic synapse | Adcy4,PRKACB,BCL2,JAK2,ACHE,KRAS,GNAI3,GNAI1,PLCB2,CAMK2B |
| GnRH signaling pathway | GNAQ,RAF1B,CALM1A,CALM3,MAPK7,MAP3K3,CALML5,MMP2,MAPK14B,CAMK2A |
Protein Function
GNA11 has several biochemical functions, for example, G-protein beta/gamma-subunit complex binding,GTP binding,GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GNA11 itself. We selected most functions GNA11 had, and list some proteins which have the same functions with GNA11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| type 2A serotonin receptor binding | ARRB2,GNAQ |
| GTPase activity | RHOB,GNA13B,RAB35B,GNAIA,RAB41,RAB13,GBP1,RAB18B,RAB5C,TUBG1 |
| signal transducer activity | GPR34A,TAAR13D,VALOPA,GNA12A,GMFB,PLCB2,SHISA5,MAPKAPK2,TAAR13E,GNAI3 |
| metal ion binding | TRP63,ZFP526,FBXO5,PRIM1,PPM1L,ATP1A3B,KLF3,FTR82,ZNF468,ZFP787 |
| G-protein beta/gamma-subunit complex binding | GNAIA,GNAI1,GNA14,GNAO1B,GNAQ,GNAT1,GNAT2,GNAI2B,CETN2,GNAO1A |
| GTP binding | GFM1,RHOF,RIT2,ARFIP2,RAB2A,LGALS6,ARL4CA,SUCLG1,GNAIA,IRGF1 |
Interacting Protein
GNA11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNA11 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNA11.
q5ni24_fratt;pi3p;CFTR;Tpm1;Actb;TMEM63B;Coro1c
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References
- Kusters-Vandevelde, HVN; Kusters, B; et al. Primary Melanocytic Tumors of the Central Nervous System: a Review with Focus on Molecular Aspects. BRAIN PATHOLOGY 25:209-226(2015).
- Koelsche, C; Hovestadt, V; et al. Melanotic Tumors of the Nervous System are Characterized by Distinct Mutational, Chromosomal and Epigenomic Profiles. BRAIN PATHOLOGY 25:202-208(2015).
