Recombinant Human GNA11 protein, GST-tagged

• Cat.No.: GNA11-186H
• Product Overview: Recombinant Human GNA11 fused with GST tag at N-terminal was expressed in E. coli.

Specification

• Description: Guanine nucleotide-binding proteins (G proteins) are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits, and function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. Guanine nucleotide-binding protein subunit alpha-11 (GNA11) acts as an activator of phospholipase C. Involved in signaling of gonadotropin-releasing hormone receptor, negatively regulating cell growth. Down-regulation may be involved in human breast cancers.
• Source: E. coli
• Species: Human
• Tag: GST
• Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: 66 kDa
• Purity: >70%
• Applications: Enzyme Assay, Western Blot
• Stability: 1 year at -70 centigrade date of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.05μg/μl

Gene Information

• Gene Name: GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) [ Homo sapiens ]
• Official Symbol: GNA11
• Synonyms: guanine nucleotide binding protein (G protein), alpha 11 (Gq class); 4379; Ensembl:ENSG00000088256; guanine nucleotide-binding protein subunit alpha-11;g alpha-11;G-protein subunit alpha-11;guanine nucleotide-binding protein, Gq class, GNA11;guanine nucleotide-binding protein G(y) subunit alpha; GNA-11
• Gene ID: 2767
• mRNA Refseq: NM_002067.2
• Protein Refseq: NP_002058.2
• MIM: 139313
• UniProt ID: P29992