Recombinant Human GNA11 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: GNA11-3785H
• Product Overview: GNA11 MS Standard C13 and N15-labeled recombinant protein (NP_002058) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 42.1 kDa
• AA Sequence: MTLESMMACCLSDEVKESKRINAEI EKQLRRDKRDARRELKLLLLGTGES GKSTFIKQMRIIHGAGYSEEDKRGF TKLVYQNIFTAMQAMIRAMETLKIL YKYEQNKANALLIREVDVEKVTTFE HQYVSAIKTLWEDPGIQECYDRRRE YQLSDSAKYYLTDVDRIATLGYLPT QQDVLRVRVPTTGIIEYPFDLENII FRMVDVGGQRSERRKWIHCFENVTS IMFLVALSEYDQVLVESDNENRMEE SKALFRTIITYPWFQNSSVILFLNK KDLLEDKILYSHLVDYFPEFDGPQR DAQAAREFILKMFVDLNPDSDKIIY SHFTCATDTENIRFVFAAVKDTILQ LNLKEYNLVTRTRPLEQKLISEEDL AANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: GNA11 G protein subunit alpha 11 [ Homo sapiens (human) ]
• Official Symbol: GNA11
• Synonyms: guanine nucleotide binding protein (G protein), alpha 11 (Gq class); 4379; Ensembl:ENSG00000088256; guanine nucleotide-binding protein subunit alpha-11;g alpha-11;G-protein subunit alpha-11;guanine nucleotide-binding protein, Gq class, GNA11;guanine nucleotide-binding protein G(y) subunit alpha; GNA-11
• Gene ID: 2767
• mRNA Refseq: NM_002067
• Protein Refseq: NP_002058
• MIM: 139313
• UniProt ID: P29992