GNAQ

  • Official Full Name

    guanine nucleotide binding protein (G protein), q polypeptide
  • Overview

    This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.[provided by RefSeq, Nov 2010]
  • Synonyms

    GNAQ;guanine nucleotide binding protein (G protein), q polypeptide;GAQ;SWS;CMC1;G-ALPHA-q;guanine nucleotide-binding protein G(q) subunit alpha;guanine nucleotide-binding protein alpha-q

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Rat
  • Chicken
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cells
  • In Vitro Cell Free System
  • Baculovirus
  • GST
  • His
  • DDK
  • Myc
  • Non
  • Flag
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
GNAQ-13350H Recombinant Human GNAQ protein, GST-tagged E.coli Human GST 84-205 aa
GNAQ-8728H Recombinant Human GNAQ, His-tagged E.coli Human His 1-359aa
GNAQ-02H Recombinant Human GNAQ Protein, Myc/DDK-tagged HEK293 Human DDK&Myc
GNAQ-1894R Recombinant Rhesus monkey GNAQ Protein, His-tagged Mammalian Cells Rhesus macaque His
GNAQ-2597R Recombinant Rat GNAQ Protein Mammalian Cells Rat His
GNAQ-3076C Recombinant Chicken GNAQ Mammalian Cells Chicken His
GNAQ-7019M Recombinant Mouse GNAQ Protein Mammalian Cells Mouse His
GNAQ-7289Z Recombinant Zebrafish GNAQ Mammalian Cells Zebrafish His
GNAQ-5867HCL Recombinant Human GNAQ 293 Cell Lysate HEK293 Human Non
GNAQ-1109HFL Recombinant Full Length Human GNAQ Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
GNAQ-1714R Recombinant Rhesus Macaque GNAQ Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
GNAQ-1714R-B Recombinant Rhesus Macaque GNAQ Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
GNAQ-2252R Recombinant Rat GNAQ Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
GNAQ-2252R-B Recombinant Rat GNAQ Protein Pre-coupled Magnetic Beads HEK293 Rat
GNAQ-2585M Recombinant Mouse GNAQ Protein (1-359 aa), His-Myc-tagged E.coli Mouse His&Myc 1-359 aa
Gnaq-3258M Recombinant Mouse Gnaq Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
GNAQ-3761M Recombinant Mouse GNAQ Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
GNAQ-3761M-B Recombinant Mouse GNAQ Protein Pre-coupled Magnetic Beads HEK293 Mouse
GNAQ-5328HF Recombinant Full Length Human GNAQ Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 359 amino acids
GNAQ-5831H Recombinant Human GNAQ Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
GNAQ-88H Recombinant Human GNAQ Full Length protein, His&Flag-tagged Baculovirus Human Flag&His Full L.
GNAQ-89H Recombinant Human GNAQ Full Length protein, His-tagged Baculovirus Human His Full L.
GNAQ-998H Recombinant Human GNAQ Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
GNAQ-998H-B Recombinant Human GNAQ Protein Pre-coupled Magnetic Beads HEK293 Human

    Involved Pathway

    GNAQ involved in several pathways and played different roles in them. We selected most pathways GNAQ participated on our site, such as Rap signaling pathway,Calcium signaling pathway,cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNAQ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Circadian entrainment PLCB4,CALM1,NOS1AP,RYR1,GUCY1A3,GRIA4,GNG3,GNB3,GNG13,GNB1
    Insulin secretion SLC2A1,RAB3A,CCKAR,RAPGEF4,KCNN2,CAMK2G,KCNMB2,KCNMB3,KCNMB1,PLCB3
    Rap signaling pathway AKT1,FGF5,CALM3,LCP2,CALML3,Fgf15,ANGPT4,ANGPT1,PGF,GNAI3
    Oxytocin signaling pathway CACNG7,CAMK2G,CACNA2D2,PRKCA,TRPM2,CACNG4,PRKAG3,PLA2G4D,PPP1R12A,PIK3R5
    GnRH signaling pathway ADCY1B,CACNA1DA,GRB2A,PLA2G4D,PRKACB,MMP14,MAPK14A,MAP2K6,GNA15.4,MAPK7
    Long-term potentiation GRIN2A,GRIN1,CALML5,CALM4,CAMK4,PRKACB,RAP1B,CALM1,MAP2K1,GRIA2
    Gap junction TUBA3C,Pdgfa&Pdgfb,ADCY1A,MAPK1,PLCB1,TUBA3A,GNAI1,MAPK3,PRKCG,PRKCA
    Salivary secretion PLCB3,PRH2,LYZ1,PLCB1,PRKACB,DMBT1,LPO,MUC5B,ATP2B4,CST1
    Sphingolipid signaling pathway PPP2R5C,BDKRB2,PPP2R2D,ACER1,PPP2R2A,SGPL1,PIK3R1,DEGS1,SGMS2,PRKCB

    Protein Function

    GNAQ has several biochemical functions, for example, G-protein beta/gamma-subunit complex binding,GTP binding,GTPase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GNAQ itself. We selected most functions GNAQ had, and list some proteins which have the same functions with GNAQ. You can find most of the proteins on our site.

    Function Related Protein
    G-protein beta/gamma-subunit complex binding GNA15.4,CETN2,GNA13A,Adcy4,GNA12A,GNAI2,GNA14,GNAI2B,GNA11B,GNAV1
    protein binding HAT1,DKK1,NUB1,CLPP,CDKN1B,TINAGL1,SERPINB9,CUTA,CCDC87,UBL4B
    signal transducer activity OLFR508,EDNRBA,GNAI1,GPR98,TAAR13C,OLFR477,CHRM2A,GPR158,TAAR12J,NDFIP2
    GTPase activator activity ARHGEF12,JUN,AXIN2,ARHGDIB,RGS17,TBC1D10A,ARHGDIG,RGS6,RGS4,NF1
    GTPase activity TUBB2B,RAB18B,REM2,LRRK2,GNAT2,DNM3,TUBA4A,RAB3B,GNG11,TUBG1
    GTP binding RAB4A,RAB3DA,SEPT11,MXC,SEPT8A,EHD3,GCH1,RAB37,RHOGC,MMAA
    metal ion binding RNF144AA,PGGT1B,KLF18,NT5C,CNBPA,TRIM55B,KLF6,ECEL1,PRICKLE2B,RNF44
    type 2A serotonin receptor binding ARRB2,GNA11

    Interacting Protein

    GNAQ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNAQ here. Most of them are supplied by our site. Hope this information will be useful for your research of GNAQ.

    RARA;ARRB1;PARP2;PECAM1;AGTR1;CXCR5;PPT1;LUM;ADHFE1;NT5C3A;pi3p;FLOT2;Myh10

    Resources

    References

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