GNG3
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Official Full Name
guanine nucleotide binding protein (G protein), gamma 3 -
Overview
G proteins are heterotrimers of alpha, beta, and gamma subunits. Gamma subunits, such as GNG3, contribute to the specificity of the hundreds of receptor signaling pathways involving G proteins (Schwindinger et al., 2004 -
Synonyms
GNG3;guanine nucleotide binding protein (G protein), gamma 3;guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3;guanine nucleotide binding protein gamma 3 subunit;NBP gamma 3;GBG3_HUMAN;Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-3 subunit;NBP gamma-3;OTTHUMP00000236158;guanine nucleotide-binding protein gamma-3 subunit
Recombinant Proteins
- Rhesus macaque
- Human
- Mouse
- Zebrafish
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli
- His
- Non
- Avi
- Fc
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GNG3-1905R | Recombinant Rhesus monkey GNG3 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| GNG3-28960TH | Recombinant Human GNG3 | Wheat Germ | Human | Non | 75 amino acids |
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| GNG3-7037M | Recombinant Mouse GNG3 Protein | Mammalian Cells | Mouse | His |
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| GNG3-9348Z | Recombinant Zebrafish GNG3 | Mammalian Cells | Zebrafish | His |
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| GNG3-5852HCL | Recombinant Human GNG3 293 Cell Lysate | HEK293 | Human | Non |
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| GNG3-1725R | Recombinant Rhesus Macaque GNG3 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
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| GNG3-1725R-B | Recombinant Rhesus Macaque GNG3 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| GNG3-216HF | Recombinant Full Length Human GNG3 Protein | In Vitro Cell Free System | Human | Full L. 75 amino acids |
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| GNG3-301307H | Recombinant Human GNG3 protein, GST-tagged | E.coli | Human | GST | Met1-Thr60 |
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| GNG3-3774M | Recombinant Mouse GNG3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| GNG3-3774M-B | Recombinant Mouse GNG3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| GNG3-5069H | Recombinant Human GNG3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GNG3-5388HF | Recombinant Full Length Human GNG3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 75 amino acids |
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Involved Pathway
GNG3 involved in several pathways and played different roles in them. We selected most pathways GNG3 participated on our site, such as Ras signaling pathway,Chemokine signaling pathway,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Retrograde endocannabinoid signaling | GNB2,PRKACA,ABHD6,MAPK12,GABRG3,GNB1,GABRA2,PLCB1,MAPK9,GRM5 |
| Circadian entrainment | CALM3,GRIN2D,RYR1,PLCB4,RPS6KA5,GNG10,KCNJ9,GNB4,MTNR1A,GRIA3 |
| Glutamatergic synapse | PPP3CC,GRIN2B,SLC38A3,PLD2,PRKCB,GRIK5,SHANK2,SLC17A8,PPP3R1,GNG13 |
| Ras signaling pathway | TEK,GRIN2A,FLT1,VEGFC,PRKCG,RALBP1,RALGDS,AKT1,RHOA,GNB2 |
| Serotonergic synapse | GABRB1,PLCB2,MAP2K1,ALOX15B,PRKACB,HTR1E,HTR3A,HTR5A,HRAS,HTR2A |
| Chemokine signaling pathway | CCL8,STAT3,SHC1,PREX1,PRKCD,JAK3,PPBP,XCL1,ROCK2,ADRBK2 |
| Dopaminergic synapse | DRD1,DRD4,ATF4,MAPK9,CREB3L4,GNGT2,CAMK2B,PRKCA,CREB5,PPP2R5C |
| Taste transduction | TAS2R144,TAS2R106,PRKACB,TAS2R116,Adcy4,TAS2R118,GNB3,TAS1R1,TAS2R137,TAS2R108 |
| Cholinergic synapse | PRKACG,CHRM4,CREB3L2,PRKCA,CHRNA6,KCNJ6,PIK3CD,KCNQ3,PIK3R1,GNAI1 |
Protein Function
GNG3 has several biochemical functions, for example, GTPase activity,signal transducer activity,type 1 angiotensin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNG3 itself. We selected most functions GNG3 had, and list some proteins which have the same functions with GNG3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| type 1 angiotensin receptor binding | GNB1,ARAP1,BDKRB2,ARRB2,GNA13,JAK2,AGT,TYK2,GNA13A,GNA13B |
| signal transducer activity | VALOPB,TAS2R118,TRHRB,DRD1A,GPR158,EDNRAB,TAAR8A,TAS2R201.1,AXIN1,TAAR14A |
| GTPase activity | TUBA3D,GNG10,MXB,RAB3C,GNL3L,TUBA8L4,RAB11BA,MTG1,IFT22,RHOD |
Interacting Protein
GNG3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNG3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNG3.
GNAI3;SNAP23
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References
- Gonzalez-Yanes, C; Santos-Alvarez, J; et al. Pancreastatin, a chromogranin A-derived peptide, activates G alpha(16) and phospholipase C-beta(2) by interacting with specific receptors in rat heart membranes. CELLULAR SIGNALLING 13:43-49(2001).
- Panchalingam, S; Undie, AS; et al. Optimized binding of [S-35]GTP gamma S to Gq-like proteins stimulated with dopamine D-1-like receptor agonists. NEUROCHEMICAL RESEARCH 25:759-767(2000).
