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Official Full Name glutamic-pyruvate transaminase (alanine aminotransferase)
Background This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.
Synonyms GPT; glutamic-pyruvate transaminase (alanine aminotransferase); alanine aminotransferase 1; ALT1; GPT1; AAT1; Alanine aminotransferase; ALAT1_HUMAN; Glutamate pyruvate transaminase 1; Glutamic alanine transaminase 1; Glutamic pyruvic transaminase 1; Glutamic--alanine transaminase 1; Glutamic--pyruvic transaminase 1; GPT 1; OTTHUMP00000228783; glutamic-alanine transaminase 1
    • Species :
    • Human
    • Mouse
    • Pig
    • Porcine
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Human
    • Human Heart
    • Human Liver
    • Insect Cell
    • Mammalian Cell
    • Porcine Heart
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GPT-1283H Recombinant Human Glutamic-Pyruvate Transaminase (Alanine Aminotransferase), His-tagged Human His
    Human GPT-1840H Native Human GPT Human Liver N/A
    Human GPT-187H Native Human Glutamate Pyruvate Transaminase Human Heart N/A
    Human GPT-2236H Recombinant Human GPT Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human GPT-26390TH Recombinant Human GPT, His-tagged E.coli His
    Human GPT-26879TH Native Human GPT N/A
    Human GPT-26882TH Native Human GPT N/A
    Human GPT-33H Recombinant Human GPT E.coli N/A
    Human GPT-5304H Recombinant Human GPT Protein, GST-tagged Wheat Germ GST
    Human GPT-5344H Native Human Glutamic-Pyruvate Transaminase (alanine aminotransferase) Human Liver N/A
    Human GPT-59H Recombinant Human GPT protein, His-tagged E.coli His
    Human GPT-65H Native Human Glutamate Pyruvate Transaminase (GPT) Human Heart N/A
    Mouse Gpt-131M Recombinant Mouse Gpt protein, His-tagged E.coli His
    Mouse Gpt-203M Recombinant Mouse Gpt Protein, His-tagged E.coli His
    Rat ALT-3248R Recombinant Rat ALT, His-tagged E.coli His
    Rat Gpt-206R Recombinant Rat Gpt Protein, His-tagged E.coli His
    Rat GPT-2676R Recombinant Rat GPT Protein Mammalian Cell His
    Rat Gpt-294R Recombinant Rat Gpt, His tagged Insect Cell His
    Rat Gpt-44R Recombinant Rat Gpt protein, His-tagged E.coli His
    Rat GPT-721RCL Recombinant Rat GPT cell lysate Insect Cell N/A
    Rhesus Macaque GPT-1964R Recombinant Rhesus monkey GPT Protein, His-tagged Mammalian Cell His
    Pig GPT-188S Native Swine Glutamate Pyruvate Transaminase Porcine Heart N/A
    Porcine GPT-189P Native Porcine GPT protein Porcine Heart N/A
    Pig GPT-204P Recombinant Pig GPT Protein, His/GST-tagged E.coli His/GST

    gpt involved in several pathways and played different roles in them. We selected most pathways gpt participated on our site, such as Arginine biosynthesis, Alanine, aspartate and glutamate metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with gpt were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arginine biosynthesis GLUL; NOS3; GLUD1; ASL; GLULB; NAGS; GOT2; GOT2A; GLSA; ARG2
    Alanine, aspartate and glutamate metabolism GPT2L; ALDH4A1; NIT2; FOLH1; GLS2; GOT2; GAD1; GLULB; GAD1B; GLSA
    Metabolic pathways CMPK1; MGAT3; HSD17B8; FUT8A; SAT1A.2; FECH; EXTL1; HMGCL; FOLH1; Amy1
    Carbon metabolism HAO1; ENO3; GPI; IDH3G; GOT2A; ENO1B; ACO1; DLST; MDH1AA; PSPH
    -Oxocarboxylic acid metabolism ACO2; GPT2; GOT2A; BCAT1; GPT; IDH1; GOT1; AADAT; IDH3G; IDH3B
    Biosynthesis of amino acids ARG2; ASL2; PKMA; ALDOB; GOT2A; PKLR; PFKM; PGAM1A; PGAM1B; PFKP

    gpt has several biochemical functions, for example, L-alanine:2-oxoglutarate aminotransferase activity, pyridoxal phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by gpt itself. We selected most functions gpt had, and list some proteins which have the same functions with gpt. You can find most of the proteins on our site.

    Function Related Protein
    L-alanine:2-oxoglutarate aminotransferase activity GPT2; GPT2L; GPT
    pyridoxal phosphate binding SRR; Alb; ACCSL; GAD1B; KYNU; SHMT2; ALAS1; AGXT; ETNPPL; LOC650128

    gpt has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with gpt here. Most of them are supplied by our site. Hope this information will be useful for your research of gpt.


    Selleng, S; Selleng, K; et al. Prevalence and clinical implications of anti-PF4/heparin antibodies in intensive care patients: a prospective observational study. JOURNAL OF THROMBOSIS AND THROMBOLYSIS 39:60-67(2015).
    Zhang, FS; Chen, WQ; et al. Transcriptional activity comparison of different sites in recombinant Marek's disease virus for the expression of the H9N2 avian influenza virus hemagglutinin gene. JOURNAL OF VIROLOGICAL METHODS 207:138-145(2014).

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