|Official Full Name||glutamic-pyruvate transaminase (alanine aminotransferase)|
|Background||This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.|
|Synonyms||GPT; glutamic-pyruvate transaminase (alanine aminotransferase); alanine aminotransferase 1; ALT1; GPT1; AAT1; Alanine aminotransferase; ALAT1_HUMAN; Glutamate pyruvate transaminase 1; Glutamic alanine transaminase 1; Glutamic pyruvic transaminase 1; Glutamic--alanine transaminase 1; Glutamic--pyruvic transaminase 1; GPT 1; OTTHUMP00000228783; glutamic-alanine transaminase 1|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
gpt involved in several pathways and played different roles in them. We selected most pathways gpt participated on our site, such as Arginine biosynthesis, Alanine, aspartate and glutamate metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with gpt were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Arginine biosynthesis||GLUL; NOS3; GLUD1; ASL; GLULB; NAGS; GOT2; GOT2A; GLSA; ARG2|
|Alanine, aspartate and glutamate metabolism||GPT2L; ALDH4A1; NIT2; FOLH1; GLS2; GOT2; GAD1; GLULB; GAD1B; GLSA|
|Metabolic pathways||CMPK1; MGAT3; HSD17B8; FUT8A; SAT1A.2; FECH; EXTL1; HMGCL; FOLH1; Amy1|
|Carbon metabolism||HAO1; ENO3; GPI; IDH3G; GOT2A; ENO1B; ACO1; DLST; MDH1AA; PSPH|
|-Oxocarboxylic acid metabolism||ACO2; GPT2; GOT2A; BCAT1; GPT; IDH1; GOT1; AADAT; IDH3G; IDH3B|
|Biosynthesis of amino acids||ARG2; ASL2; PKMA; ALDOB; GOT2A; PKLR; PFKM; PGAM1A; PGAM1B; PFKP|
gpt has several biochemical functions, for example, L-alanine:2-oxoglutarate aminotransferase activity, pyridoxal phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by gpt itself. We selected most functions gpt had, and list some proteins which have the same functions with gpt. You can find most of the proteins on our site.
|L-alanine:2-oxoglutarate aminotransferase activity||GPT2; GPT2L; GPT|
|pyridoxal phosphate binding||SRR; Alb; ACCSL; GAD1B; KYNU; SHMT2; ALAS1; AGXT; ETNPPL; LOC650128|
gpt has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with gpt here. Most of them are supplied by our site. Hope this information will be useful for your research of gpt.
CDC7; RALA; SASS6