GRM5
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Official Full Name
glutamate receptor, metabotropic 5
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Overview
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009] -
Synonyms
GRM5; glutamate receptor, metabotropic 5; mGlu5; GPRC1E; MGLUR5; metabotropic glutamate receptor 5; GRM5 variant 9; metabotropic glutamate receptor 5 variant F; metabotropic glutamate receptor 5 variant G; metabotropic glutamate receptor 5 variant H;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rat
- E.coli
- HEK293
- Insect Cell
- Mammalian Cell
- Wheat Germ
- Flag,His
- GST
- His
- His (Fc)
- Avi
- Flag
- Myc
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | GRM5-5733HCL | Recombinant Human GRM5 293 Cell Lysate | HEK293 | N/A |
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| Human | GRM5-1143HFL | Recombinant Human GRM5 protein, His&Flag-tagged | HEK293 | His&Flag | 1-1180 aa |
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| Human | GRM5-5368H | Recombinant Human GRM5 Protein, GST-tagged | Wheat Germ | GST |
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| Human | GRM5-0501H | Recombinant Human GRM5 Protein (P569-K678, E579A, N667Y, I669A, G675M, K679-A836, T742A, S753A), Flag, His tagged | Insect Cell | Flag,His | P569-K678, E579A, N667Y, I669A, G675M, K679-A836, T742A, S753A |
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| Human | GRM5-2996H | Recombinant Human GRM5 protein, His&Myc-tagged | E.coli | His&Myc | 22-580aa |
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| Rat | GRM5-2717R | Recombinant Rat GRM5 Protein | Mammalian Cell | His |
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| Rat | GRM5-2371R-B | Recombinant Rat GRM5 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | GRM5-2371R | Recombinant Rat GRM5 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Chicken | GRM5-5714C | Recombinant Chicken GRM5 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- GRM5 Related Articles
- GRM5 Related Research Area
GRM5 involved in several pathways and played different roles in them. We selected most pathways GRM5 participated on our site, such as Calcium signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRM5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium signaling pathway | ADCY2B;GNA11B;ATP2A3;PRKACG;PLCD3A;ERBB2;CAMK2B1;CALML5;CCKAR |
| Phospholipase D signaling pathway | PLA2G4F;PLA2G4A;FCER1A;FCER1G;MRAS;PLA2G4D;PLD1;PIK3R1;LPAR3 |
| Neuroactive ligand-receptor interaction | TACR1;MTNR1B;P2RY13;TACR3A;P2RX3;TAAR14B;TAAR12G;GRIN1B;MC5RA |
| Gap junction | TUBA8L4;ITPR3;PLCB3;GRB2A;HRASB;PLCB2;CDK1;PRKG1;HRASA |
| Long-term potentiation | PRKCB;GRIN2D;BRAF;MAPK1;KRAS;ATF4;CALM4;GRIA1;RAP1A |
| Retrograde endocannabinoid signaling | GABRG1;GNAQ;ABHD6;GABRA4;GNG7;PLCB2;GNB1;GABRA5;PLCB4 |
| Glutamatergic synapse | GRM8;PRKACA;PLCB2;SLC1A3;MAPK1;GLS2;GRIK2;GRM4;PLA2G4F |
| Huntingtons disease | NDUFS5;UCP1;NDUFB11;UQCRH;DNALC1;NDUFS3;COX7A1;DCTN2;COX7B2 |
GRM5 has several biochemical functions, for example, A2A adenosine receptor binding, G-protein coupled receptor activity, glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRM5 itself. We selected most functions GRM5 had, and list some proteins which have the same functions with GRM5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| A2A adenosine receptor binding | |
| G-protein coupled receptor activity | PTGER1C;FZD7A;TAAR13B;TAAR12C;GPRC6A;DRD4B;OR6K3;TAAR7F;OR13A1 |
| glutamate receptor activity | GRIA1;GRM2;GRM6;GRID2;GRM1;GRM8;GRIK5;GRM3;GRM5 |
GRM5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRM5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRM5.
PRKCZ; PRKCD
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