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GRM5

Official Full Name

glutamate receptor, metabotropic 5
Overview

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
Synonyms

GRM5; glutamate receptor, metabotropic 5; mGlu5; GPRC1E; MGLUR5; metabotropic glutamate receptor 5; GRM5 variant 9; metabotropic glutamate receptor 5 variant F; metabotropic glutamate receptor 5 variant G; metabotropic glutamate receptor 5 variant H;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rat

Source

E.coli
HEK293
Insect Cell
Mammalian Cell
Wheat Germ

Tag

GST
His
Fc
Avi
Flag
Myc
Non

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GRM5-5733HCL	Recombinant Human GRM5 293 Cell Lysate	HEK293	Non		Inquiry
Human	GRM5-1143HFL	Recombinant Human GRM5 protein, His&Flag-tagged	HEK293	His&Flag	1-1180 aa	Inquiry
Human	GRM5-5368H	Recombinant Human GRM5 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GRM5-0501H	Recombinant Human GRM5 Protein (P569-K678, E579A, N667Y, I669A, G675M, K679-A836, T742A, S753A), Flag, His tagged	Insect Cell	His&Flag	P569-K678, E579A, N667Y, I669A, G675M, K679-A836, T742A, S753A	Inquiry
Human	GRM5-2996H	Recombinant Human GRM5 protein, His&Myc-tagged	E.coli	His&Myc	22-580aa	Inquiry
Rat	GRM5-2717R	Recombinant Rat GRM5 Protein	Mammalian Cell	His		Inquiry
Rat	GRM5-2371R-B	Recombinant Rat GRM5 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	GRM5-2371R	Recombinant Rat GRM5 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Chicken	GRM5-5714C	Recombinant Chicken GRM5	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

GRM5 involved in several pathways and played different roles in them. We selected most pathways GRM5 participated on our site, such as Calcium signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRM5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Calcium signaling pathway	ITPR3;GRM1;ATP2B4;CAMK2D1;PLCB4;PLCD4;EDNRB;CACNA1SB;ATP2A2B
Phospholipase D signaling pathway	RALGDS;RALB;SHC1;RRAS;Adcy4;GRM5;HRAS;AGTR1B;GAB2
Neuroactive ligand-receptor interaction	GLRA3;GH1;ADRB2B;TAAR7B;CHRNB3;MLNR;TAAR11;EDNRAA;HTR1AA
Gap junction	HTR2C;GJA1;TUBA3E;PRKCBB;CSNK1DA;TUBA1C;MAP2K1;TUBA8L3;HTR2CL1
Long-term potentiation	PPP3R2;PRKACB;PPP1CC;CALML3;PRKACA;GRIN1;ATF4;GNAQ;GRIN2C
Retrograde endocannabinoid signaling	GABRA2;GABRR1;GABRA6;GNAI2;GNAO1;GNG10;GRM5;GABRB1;PRKACA
Glutamatergic synapse	PLA2G4A;SHANK2;HOMER1;GRIN2D;GRIK3;SHANK1;PRKACG;GNG7;GNG10
Huntingtons disease	ATP5J;POLR2H;SDHA;COX5B;GNAQ;ATP5E;TAF4B;COX8A;DNAH6

GRM5 has several biochemical functions, for example, A2A adenosine receptor binding, G-protein coupled receptor activity, glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRM5 itself. We selected most functions GRM5 had, and list some proteins which have the same functions with GRM5. You can find most of the proteins on our site.

Function	Related Protein
A2A adenosine receptor binding
G-protein coupled receptor activity	OPN1SW2;GPR27;CXCR4;GPR55A;TAS2R202;GPR62;GPR183;APLNRB;GRIN1A
glutamate receptor activity	GRM8;GRM7;GRID2;GRM5;GRM1;GRIK3;GRM6;GRM3;GRM4

GRM5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRM5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRM5.

PRKCZ; PRKCD