|Official Full Name||hemoglobin, beta|
|Background||The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5-epsilon -- gamma-G -- gamma-A -- delta -- beta--3.|
|Synonyms||HBB; hemoglobin, beta; hemoglobin subunit beta; beta globin; CD113t C; HBD; beta globin chain; hemoglobin beta chain; CD113t-C; beta-globin|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
hbb involved in several pathways and played different roles in them. We selected most pathways hbb participated on our site, such as African trypanosomiasis, Malaria, which may be useful for your reference. Also, other proteins which involved in the same pathway with hbb were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|African trypanosomiasis||IFNG; F2RL1; MYD88; VCAM1; HPR; APOL1; IDO1; HBB-B1; IL18; IL6|
|Malaria||GYPA; THBS1; HBA2; SDC1; Ccl12; CSF3; CD40LG; SDC2; TLR4; SELP|
hbb has several biochemical functions, for example, contributes_to haptoglobin binding, heme binding, hemoglobin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by hbb itself. We selected most functions hbb had, and list some proteins which have the same functions with hbb. You can find most of the proteins on our site.
|contributes_to haptoglobin binding||HBB; HBA-A2; HBA1; HBA2|
|heme binding||CYP2X9; CYP3C1; HBE; CYP2R1; CYP2D6; BACH1; CYP21A1; HRG; CYP46A1.1; SRC|
|hemoglobin binding||CUBN; HPR; HP; HBB; AHSP; LRP2|
|iron ion binding||EGLN1; CYP4A14; CYP2K16; AOX4; CYP4V8; Agmo; FBXL5; CYP11B1; CYP3A25; HBAD|
|oxygen binding||CYP2R1; CYP2AA7; CYP17A1; CYP2N13; CYP2X10.2; FAM84B; CYP2B6; CYP2B19; CYP2AA3; CYP2C19|
|oxygen transporter activity||HBB-Y; HBM; HBE1; HBE; HBBE3; HBAE1; HBB-BH1; BA1; HBAA; HBBE2|
|contributes_to peroxidase activity||HBA2; HBB; HBA-A2; HBA1|
|protein binding||PHLDA1; TRIP12; FAM162A; EP400; TRIAP1; HHEX; SYT1; MCPH1; MTMR2; IMMT|
hbb has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hbb here. Most of them are supplied by our site. Hope this information will be useful for your research of hbb.