Native Human Hemoglobin S, Ferrous Stabilized

• Cat.No.: HBB-001H
• Product Overview: Solubility
  H2O: soluble 20 mg/mL
  Suitability
  Suitable for electrophoresis and chromatography standard (has not been tested for functional equivalence against native preparations (unlyophilized ferrous hemoglobins).)

Specification

• Description: The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.
• Species: Human
• Form: Lyophilized powder
• Applications: Hemoglobin S was used in the determination of fetal hemoglobin by time-resolved immunofluorometric assay.
• Storage: At -20 centigrade.
• Reconstitution: When reconstituted with buffer, gives >90% ferrous hemoglobin.

Gene Information

• Gene Name: HBB
• Official Symbol: HBB hemoglobin subunit beta [ Homo sapiens (human) ]
• Synonyms: Sickle cell hemoglobin; HBB; hemoglobin subunit beta; CD113t-C; beta-globin; hemoglobin subunit beta; beta globin chain; hemoglobin, beta
• Gene ID: 3043
• mRNA Refseq: NM_000518
• Protein Refseq: NP_000509
• MIM: 141900
• UniProt ID: P68871