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Official Full Name major histocompatibility complex, class I, A
Background HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.
Synonyms HLA-A; major histocompatibility complex, class I, A; HLA class I histocompatibility antigen, A-1 alpha chain; antigen presenting molecule; leukocyte antigen class I-A; MHC class I antigen HLA-A heavy chain; HLAA; FLJ26655
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Wheat Germ
    • Tag :
    • GST
    • His-Avi
    • His-B2M
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-A-4302H Recombinant Human HLA-A protein, His-B2M-tagged E.coli His-B2M
    Human HLA-A-068H Recombinant HLA-A*0201 WT-1 (RMFPNAPYL) complex protein, His-Avi-tagged HEK293 His-Avi
    Human HLA-A-069H Recombinant Human HLA-A0201 WT-1 (RMFPNAPYL) complex Protein (tetramer), His-Avi-tagged HEK293 His-Avi
    Human HLA-A-2390H Recombinant Human HLA-A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human HLA-A-4832H Recombinant Human HLA-A Protein, GST-tagged Wheat Germ GST
    Human HLA-A-5503HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A
    Human HLA-A-573HB Recombinant Human HLA-A*0201 NY-ESO-1 (SLLMWITQC) complex protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Human HLA-A-732H Recombinant Human HLA-A0201 gp100 (YLEPGPVTA) complex protein, His-Avi-tagged HEK293 His-Avi
    Human HLA-A-733H Recombinant Human HLA-A0201 MAGE-A4 (GVYDGREHTV) complex protein, His-Avi-tagged HEK293 His-Avi
    Human HLA-A-938H Recombinant Human HLA-A protein, MYC/DDK-tagged HEK293 Myc/DDK

    hla-a involved in several pathways and played different roles in them. We selected most pathways hla-a participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with hla-a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis VPS37A; RAB11BB; RAB11FIP3; DNM2B; EPS15; HLA-B; TGFB1; CLTCA; CHMP2BA; DNM1B
    Phagosome HLA-DOA; FCGR1A; ATP6V0A1A; ATP6V1G2; H2-Q10; HBL4; ATP6V1E1; TLR4BB; TUBAL3; HLA-G
    Cell adhesion molecules (CAMs) MPZ; CDH15; PTPRC; NLGN2; CLDN17; BF1; CNTN1A; CLDN7A; CLDN6; CLDNJ
    Antigen processing and presentation HSP90AB1; HLA-DQA2; HLA-DQA1; KIR2DL1; PSME1; HLA-E; HLA-B; PDIA3; KLRC2; PSME2
    Natural killer cell mediated cytotoxicity TYROBP; ICAM2; ITGB2L; RAC2; SH2D1B; FCGR3B; LCP2; RAET1D; HLA-E; TNFSF10
    Type I diabetes mellitus HLA-DQA1; HLA-A; LTA; HLA-DMA; PRF1; CD80; HLA-DRB4; INS2; Il2; PTPRN
    HTLV-I infection Adcy4; KAT2A; ATF4; HLA-DPB1; KRAS; KAT2B; FZD7; PDGFA; FDPS; MYBL1
    Herpes simplex infection HLA-A; FB06F03; IFNAR2; HLA-C; IFNA14; C3A.2; IKBKE; MHC2DEB; IRF7; IL12BA
    Epstein-Barr virus infection MAP2K3; CD38; MAPK13; ITGAL; IL10RA; MAPK10; SPN; POLR3K; POLR2A; HLA-DRB5
    Viral carcinogenesis TBPL1; PRKACA; PRKACG; PMAIP1; KAT2A; ATP6V0D1; HIST1H2BB; HIST1H2BI; ACTN3; EP300
    ne thyroid disease HLA-DQB1; IFNA13; HLA-DRB1; IFNA8; IFNA12; HLA-G; HLA-B; FASLG; HLA-DMB; HLA-C
    Allograft rejection HLA-DPA1; HLA-A; HLA-E; IFNG; IL12B; HLA-DMB; H2-AA; IL5; HLA-DRB1; IL10
    Graft-versus-host disease HLA-E; FAS; HLA-DPB1; KIR2DL1; HLA-A; Il2; Fasl; FASLG; KIR2DL3; H2-Q10
    Viral myocarditis SGCB; HLA-DOA; CAV1; EIF4G2; PRF1; CCND1; HLA-G; ABL1; HLA-DMA; CD40

    hla-a has several biochemical functions, for example, T cell receptor binding, TAP binding, beta-2-microglobulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by hla-a itself. We selected most functions hla-a had, and list some proteins which have the same functions with hla-a. You can find most of the proteins on our site.

    Function Related Protein
    T cell receptor binding FYN; EPS8L1; CD3E; DOCK2; CD1d1; HLA-A; CD3G; H2-Q10
    TAP binding HLA-B; H2-Q10; HLA-C; HLA-A
    beta-2-microglobulin binding CD1C; CD1d1; HLA-A; H2-Q10; CD1E; CD1A; CD1D2; CD1D; CD1B; HLA-E
    peptide antigen binding HLA-DRA; HLA-DRB3; MHC1ZDA; MHC1UBA; MHC1UJA; HLA-F; HLA-A; H2-AB1; HLA-DQA1; HLA-DPB1
    poly(A) RNA binding RPL13; NKAP; RPL32; HDLBP; KIAA1967; ASS1; TBCA; GLRX3; KHSRP; HNRNPC
    protein binding SYCE2; BRD2; AXL; SPG21; TBX5A; SLC9A7; RAB37; VDAC2; ZSCAN1; GATAD2B
    receptor binding FGF12B; LGI1; CXCL10; CD72; NCR3; RSPO2; PVRL1B; MIF; CD276; PLAT

    hla-a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hla-a here. Most of them are supplied by our site. Hope this information will be useful for your research of hla-a.

    B2M; ganglioside_gm1; Cep85l; Bmpr1a; ATXN3; Arhgef17; PCDHB15

    Olvera, A; Perez-Alvarez, S; et al. The HLA-C*04:01/KIR2DS4 gene combination and human leukocyte antigen alleles with high population frequency drive rate of HIV disease progression. AIDS 29:507-517(2015).
    Kusnierczyk, P; Mozer-Lisewska, I; et al. Contribution of genes for killer cell immunoglobulin-like receptors (KIR) to the susceptibility to chronic hepatitis C virus infection and to viremia. HUMAN IMMUNOLOGY 76:102-108(2015).

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