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HLA-A

Official Full Name

major histocompatibility complex, class I, A
Overview

HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.
Synonyms

HLA-A; major histocompatibility complex, class I, A; HLA class I histocompatibility antigen, A-1 alpha chain; antigen presenting molecule; leukocyte antigen class I-A; MHC class I antigen HLA-A heavy chain; HLAA; FLJ26655;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human

Source

E.coli
HEK
HEK293
HEK293T
In Vitro Cell Free System
Insect Cell
Mamanlian cells
Mammalian cells
Wheat Germ

Tag

Avi
Flag
GST
His
B2M
Myc
DDK
Non

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	HLA-A-938H	Recombinant Human HLA-A protein, MYC/DDK-tagged	HEK293	Myc&DDK		Inquiry
Human	HLA-A-4832H	Recombinant Human HLA-A Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	HLA-A-5503HCL	Recombinant Human HLA 293 Cell Lysate	HEK293	Non		Inquiry
Human	HLA-A-573HB	Recombinant Human HLA-A*0201 NY-ESO-1 (SLLMWITQC) complex protein, His-Avi-tagged, Biotinylated	HEK293	His&Avi	It contains Gly 25 - Thr 305 (HLA-A*0201),Ile21-Met119 (B2M) and SLLMWITQC peptide.	Inquiry
Human	HLA-A-732H	Recombinant Human HLA-A0201 gp100 (YLEPGPVTA) complex protein, His-Avi-tagged	HEK293	His&Avi	It contains Gly 25 - Thr 305 (HLA-A*0201),Ile21-Met119 (B2M) and YLEPGPVTA peptide design.	Inquiry
Human	HLA-A-3396H	Recombinant Human HLA-A protein, His-tagged	E.coli	His	28-303 aa	$319 / 25μg
Human	HLA-A-068H	Recombinant HLA-A*0201 WT-1 (RMFPNAPYL) complex protein, His-Avi-tagged	HEK293	His&Avi	It contains Gly 25 - Thr 305 (HLA-A*0201),Ile21-Met119 (B2M) and RMFPNAPYL peptide design	Inquiry
Human	HLA-A-2390H	Recombinant Human HLA-A Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc&DDK		Inquiry
Human	HLA-A-733H	Recombinant Human HLA-A0201 MAGE-A4 (GVYDGREHTV) complex protein, His-Avi-tagged	HEK293	His&Avi	It contains Gly 25 - Thr 305 (HLA-A*0201),Ile21-Met119 (B2M) and GVYDGREHTV peptide design	Inquiry
Human	HLA-A-3958H	Recombinant Human HLA-A protein, His-tagged	E.coli	His	25-308aa	Inquiry
Human	HLA-A-069H	Recombinant Human HLA-A0201 WT-1 (RMFPNAPYL) complex Protein (tetramer), His-Avi-tagged	HEK293	His&Avi	It contains Gly 25 - Thr 305 (HLA-A*0201),Ile21-Met119 (B2M) and RMFPNAPYL peptide design.	Inquiry
Human	HLA-A-3557HF	Recombinant Full Length Human HLA-A Protein, GST-tagged	In Vitro Cell Free System	GST	24-365 amino acids	Inquiry
Human	HLA-A-4302H	Recombinant Human HLA-A protein, His-B2M-tagged	E.coli	His&B2M	25-299aa	Inquiry
Human	HLA-A-1448H	Recombinant Human HLA-A protein, His-tagged	Insect Cell	His	25-308aa	Inquiry
Human	HLA-A-2242H	Recombinant Human HLA-A Protein, His-tagged	E.coli	His	Tyr83-Ser352	Inquiry
Human	HLA-A-01H	Recombinant Human HLA-A Protein, C-His tagged	HEK	His		Inquiry
Human	HLA-A-2623HFL	Recombinant Full Length Human HLA-A protein, Flag-tagged	Mamanlian cells	Flag		Inquiry
Human	HLA-A-730HP	Recombinant Human HLA-A complex Protein (tetramer), His-Avi-tagged, PE-Labeled	HEK293	His&Avi	Gly25-Thr305(HLA-A*02:01),Ile21-Met119(B2M) and SLLMWITQC peptide	Inquiry
Human	HLA-A-1500H	Recombinant Human HLA-A protein, His&Myc-tagged	E.coli	His&Myc	25-308aa	Inquiry
Human	HLA-A-2935H	Recombinant Human HLA-A Protein (Gly25-Trp298), N-His tagged	E.coli	His	Gly25-Trp298	Inquiry
Human	HLA-A-2936H	Recombinant Human HLA-A Protein (Gly25-Leu300), N-His tagged	E.coli	His	Gly25-Leu300	Inquiry
Human	HLA-A-2937H	Recombinant Human HLA-A Protein (Full Length), Avi tagged	E.coli	Avi	Full Length	Inquiry
Human	HLA-A-2938H	Recombinant Human HLA-A Protein (Met1-Pro304), C-His and Avi tagged	Mammalian cells	His&Avi	Met1-Pro304	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

HLA-A involved in several pathways and played different roles in them. We selected most pathways HLA-A participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Endocytosis	FGFR2;PIP5K1C;GRK1;HSP70L;ARAP1;CAPZA2;CBL;CAPZA1B;SNF8
Phagosome	TUBA3E;RAC1;DYNC1I2A;FCGR3;FCAR;HLA-DRB1;TUBB1;SEC61G;BF1
Cell adhesion molecules (CAMs)	CLDN11B;CD86;CLDN15LB;PVRL3B;ITGB2;CLDN8;CLDNJ;HLA-DRB4;NRCAMA
Antigen processing and presentation	HSPA1B;PSME2;CD8B1;HSP90AA1;PDIA3;HLA-DRB1;HLA-DPA1;TAP1;IFI30
Natural killer cell mediated cytotoxicity	RAET1E;PTK2B;ULBP3;TNFRSF10C;IFNGR1;NFATC2;PRF1;IFNA14;HLA-G
Type I diabetes mellitus	GAD1;Fasl;PRF1;FAS;HLA-DQB1;IL12B;HLA-DPA1;FASLG;CD28
HTLV-I infection	PIK3R1;BUB3;CDC27;WNT2B;MAPK8;TLN1;ETS1;RRAS;PDGFA
Herpes simplex infection	Ccl12;SRSF7;PPP1CAA;STAT1A;IFNA4;PTPN11A;CFP;IL12BA;NFKBIAA
Epstein-Barr virus infection	POLR2J;HLA-C;POLR2A;YWHAE;HDAC2;PIK3CB;YWHAZ;SPI1;PSMD8
Viral carcinogenesis	HIST1H4H;GTF2H3;SYK;SKP2;HIST1H2BD;HDAC7A;HDAC2;RBL2;GTF2A1
Autoi	HLA-DRA;IFNA10;HLA-DRB1;HLA-G;HLA-F;HLA-A;GZMB;TG;IFNA8
ne thyroid disease	HLA-B;IFNA7;GZMB;IFNA4;CD28;HLA-DRB4;HLA-DPA1;FASLG;IFNA5
Allograft rejection	HLA-B;HLA-DPA1;HLA-DOA;FASLG;HLA-DMA;HLA-DQB1;IL10;MICA;HLA-F
Graft-versus-host disease	H2-AA;HLA-DOA;TNF;KIR3DL1;HLA-DRB5;CD86;HLA-DMA;IFNG;FAS
Viral myocarditis	HLA-B;HLA-F;SGCB;ACTG1;SGCA;HLA-DMB;FYN;EIF4G3;CASP8

HLA-A has several biochemical functions, for example, T cell receptor binding, TAP binding, beta-2-microglobulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-A itself. We selected most functions HLA-A had, and list some proteins which have the same functions with HLA-A. You can find most of the proteins on our site.

Function	Related Protein
T cell receptor binding	FYN;CD1d1;CD3E;H2-Q10;HLA-A;CD3G;EPS8L1;DOCK2
TAP binding	HLA-A;HLA-B;HLA-C;H2-Q10
beta-2-microglobulin binding	CD1B;CD1D;CD1C;CD1A;CD1d1;CD1D2;H2-Q10;CD1E;HFE
peptide antigen binding	TRGV3;MHC1UHA;MHC1ZDA;MHC1UBA;MHC1UEA;HLA-C;MHC1ZE;HLA-DRB3;MHC1UIA
poly(A) RNA binding	SUGP1;TRIM28;ZNFX1;MACF1;ZFP326;CORO1A;GRN;ZYX;TIAL1
protein binding	FCHSD2;VASP;CDH1;TNFRSF11A;TBC1D16;GBP2;SERPINI2;CLIC5;CBFA2T2
receptor binding	FKBP1B;IDUA;A2M;IAPP;PDGFRB;CXCL10;CAPRIN2;ADIPOQ;ANGPTL1

HLA-A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-A here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-A.

B2M; ganglioside_gm1; Cep85l; Bmpr1a; ATXN3; Arhgef17; PCDHB15

Gene Family

Research Area

MHC Class I

MHC Class II

T Cell Antigen Recognition

Olvera, A; Perez-Alvarez, S; et al. The HLA-C*04:01/KIR2DS4 gene combination and human leukocyte antigen alleles with high population frequency drive rate of HIV disease progression. AIDS 29:507-517(2015).

Kusnierczyk, P; Mozer-Lisewska, I; et al. Contribution of genes for killer cell immunoglobulin-like receptors (KIR) to the susceptibility to chronic hepatitis C virus infection and to viremia. HUMAN IMMUNOLOGY 76:102-108(2015).