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HMGB3

Official Full Name

high mobility group box 3
Overview

HMGB3 belongs to the high mobility group (HMG) protein superfamily. Like HMG1 (MIM 163905) and HMG2 (MIM 163906), HMGB3;contains DNA-binding HMG box domains and is classified into the HMG box subfamily. Members of the HMG box subfamily;are thought to play a fundamental role in DNA replication, nucleosome assembly and transcription (Wilke et al., 1997;(PubMed 9370291); Nemeth et al., 2006 (PubMed 16945912)).
Synonyms

HMGB3; high mobility group box 3; high mobility group (nonhistone chromosomal) protein 4 , high mobility group box 3 , HMG4; high mobility group protein B3; HMG2A; MGC90319; non histone chromosomal protein; High mobility group protein 2a; High mobility group protein HMG4; HMG 4; HMGB 3; Nonhistone chromosomal protein HMG4; high-mobility group box 3; high mobility group protein 4; non-histone chromosomal protein; high-mobility group (nonhistone chromosomal) protein 4; HMG4; HMG-4; HMG-2a;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Mammalian cells
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	HMGB3-15882H	Recombinant Human HMGB3, His-tagged	E.coli	His	1-180aa	Inquiry
Human	HMGB3-105H	Recombinant Human HMGB3, His-tagged	HEK293	His	Ala2-Glu200	Inquiry
Human	HMGB3-4872H	Recombinant Human HMGB3 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	HMGB3-801HCL	Recombinant Human HMGB3 cell lysate		Non		Inquiry
Human	HMGB3-3010H	Recombinant Human HMGB3 protein, His-tagged	E.coli	His	1-103 aa	$319 / 25μg
Human	HMGB3-301335H	Recombinant Human HMGB3 protein, GST-tagged	E.coli	GST	Met1-Phe103	Inquiry
Human	HMGB3-3356H	Recombinant Human HMGB3 Protein (Ser14-Ala176), N-His tagged	E.coli	His	Ser14-Ala176	Inquiry
Human	HMGB3-3645HF	Recombinant Full Length Human HMGB3 Protein, GST-tagged	In Vitro Cell Free System	GST	200 amino acids	Inquiry
Human	HMGB3-3355H	Recombinant Human HMGB3 Protein (Met1-Glu200), C-His tagged	Mammalian cells	His	Met1-Glu200	Inquiry
Mouse	HMGB3-7730M	Recombinant Mouse HMGB3 Protein	Mammalian Cell	His		Inquiry
Mouse	HMGB3-4238M	Recombinant Mouse HMGB3 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	HMGB3-4238M-B	Recombinant Mouse HMGB3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	Hmgb3-1627R	Recombinant Rat Hmgb3 Protein, His-tagged	E.coli	His	Ser14-Ala176	Inquiry
Chicken	HMGB3-6847C	Recombinant Chicken HMGB3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

HMGB3 involved in several pathways and played different roles in them. We selected most pathways HMGB3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

HMGB3 has several biochemical functions, for example, DNA binding, bending, chromatin binding, double-stranded DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGB3 itself. We selected most functions HMGB3 had, and list some proteins which have the same functions with HMGB3. You can find most of the proteins on our site.

Function	Related Protein
DNA binding, bending	TOP2B;TFAM;FOXL1;HMGA2;HMGB3;GATA1;FOXC1;CRIP1;TOP2A
chromatin binding	NSD1;MBD5;PLAC8;TOX;HDGF2;NEUROD1;RCC1;PRKAA2;NKX2
double-stranded DNA binding	MTERFD3;SAFB;MRE11A;YBX1;AFF3;NTHL1;LSM14A;SATB1;TP73
four-way junction DNA binding	MEN1;RAD51;YY1;HMGB1;DMC1;HMGB3;RAD51L1;HMGB2;RAD51L3
poly(A) RNA binding	TRAP1;RBM12B1;UNK;EWSR1;CPEB4;SRP54B;SAFB2;SRP19;FAM98B
protein binding	SSB;JUND;ZFP64;RTN4RL1;CTAG2;CSNK2A1;SPHK1;KIFC3;RNF175

HMGB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGB3.

SDCBP; TERF2IP; mdm2_human_probe

Research Area

Hematopoietic Progenitor Cell Markers

Hematopoietic Stem Cell Transcription Factors and Regulators

de Souza, AWS; Abdulahad, WH; et al. Are urinary levels of high mobility group box 1 markers of active nephritis in anti-neutrophil cytoplasmic antibody-associated vasculitis?. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 178:270-278(2014).

Kim, HY; Park, SY; et al. Inhibition of HMGB1-Induced Angiogenesis by Cilostazol via SIRT1 Activation in Synovial Fibroblasts from Rheumatoid Arthritis. PLOS ONE 9:-(2014).