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Official Full Name hypoxanthine phosphoribosyltransferase 1
Background The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate;and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl;1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage;pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.
Synonyms HPRT1; hypoxanthine phosphoribosyltransferase 1; HPRT; hypoxanthine-guanine phosphoribosyltransferase; HGPRT; Lesch Nyhan syndrome; HGPRTase; HPRT 1; HPRT_HUMAN; Hypoxanthine guanine phosphoribosyltransferase; Hypoxanthine phosphoribosyltransferase 1 (Lesch Nyhan syndrome)
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Human
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HPRT1-1796H Recombinant Human Hypoxanthine Phosphoribosyltransferase 1, His-tagged Human His
    Human HPRT1-28755TH Recombinant Human HPRT1, His-tagged E.coli His
    Human HPRT1-5011H Recombinant Human HPRT1 Protein, GST-tagged Wheat Germ GST
    Human HPRT1-5398HCL Recombinant Human HPRT1 293 Cell Lysate HEK293 N/A
    Rat HPRT1-2905R Recombinant Rat HPRT1 Protein Mammalian Cell His
    Cynomolgus Monkey HPRT1-595C Recombinant Cynomolgus HPRT1 Protein, His-tagged Mammalian Cell His
    Chicken HPRT1-6411C Recombinant Chicken HPRT1 Mammalian Cell His
    Zebrafish HPRT1-12230Z Recombinant Zebrafish HPRT1 Mammalian Cell His

    hprt1 involved in several pathways and played different roles in them. We selected most pathways hprt1 participated on our site, such as Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with hprt1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Purine metabolism POLR1E; POLA1; POLR2GL; POLE3; NME1-NME2; NME1; ENTPD8; NT5E; NUDT9; RRM2
    Drug metabolism - other enzymes UGT1A2; PNAT3; UGT1A1; GMPS; HPRT1; IMPDH2; UCKL1; IMPDH1A; UGT1A7; Ces2c
    Metabolic pathways A4GALT; ACSL4; NADKD1; SI; BCKDHB; DGKAA; IDUA; CYP2A12; PON2; AMACR

    hprt1 has several biochemical functions, for example, guanine phosphoribosyltransferase activity, hypoxanthine phosphoribosyltransferase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by hprt1 itself. We selected most functions hprt1 had, and list some proteins which have the same functions with hprt1. You can find most of the proteins on our site.

    Function Related Protein
    guanine phosphoribosyltransferase activity HPRT1
    hypoxanthine phosphoribosyltransferase activity HPRT1L; HPRT1
    magnesium ion binding ATP8A1; WEE1; ZAK; ATP4A; FAN1; OPA1; PRPS1; PKM; STK36; TSSK3
    nucleotide binding MAP2K4A; TUBB5; FGFR1B; TOR2A; GKUP; ATAD1A; SETD1B; PPARGC1B; DNAJC17; EIF4A1B
    protein binding CDIPT; CUL2; ILK; BPTF; ING4; SUGT1; TMEM31; SNX12; TEX14; MIEN1
    protein homodimerization activity PLCB1; BLOC1S6; MAOB; UGT1A1; HMGCR; EIF2AK3; SLC30A8; Defa-rs7; CIB2; DNM1L

    hprt1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hprt1 here. Most of them are supplied by our site. Hope this information will be useful for your research of hprt1.


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