|Official Full Name||hypoxanthine phosphoribosyltransferase 1|
|Background||The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate;and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl;1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage;pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.|
|Synonyms||HPRT1; hypoxanthine phosphoribosyltransferase 1; HPRT; hypoxanthine-guanine phosphoribosyltransferase; HGPRT; Lesch Nyhan syndrome; HGPRTase; HPRT 1; HPRT_HUMAN; Hypoxanthine guanine phosphoribosyltransferase; Hypoxanthine phosphoribosyltransferase 1 (Lesch Nyhan syndrome)|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
hprt1 involved in several pathways and played different roles in them. We selected most pathways hprt1 participated on our site, such as Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with hprt1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Purine metabolism||POLR1E; POLA1; POLR2GL; POLE3; NME1-NME2; NME1; ENTPD8; NT5E; NUDT9; RRM2|
|Drug metabolism - other enzymes||UGT1A2; PNAT3; UGT1A1; GMPS; HPRT1; IMPDH2; UCKL1; IMPDH1A; UGT1A7; Ces2c|
|Metabolic pathways||A4GALT; ACSL4; NADKD1; SI; BCKDHB; DGKAA; IDUA; CYP2A12; PON2; AMACR|
hprt1 has several biochemical functions, for example, guanine phosphoribosyltransferase activity, hypoxanthine phosphoribosyltransferase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by hprt1 itself. We selected most functions hprt1 had, and list some proteins which have the same functions with hprt1. You can find most of the proteins on our site.
|guanine phosphoribosyltransferase activity||HPRT1|
|hypoxanthine phosphoribosyltransferase activity||HPRT1L; HPRT1|
|magnesium ion binding||ATP8A1; WEE1; ZAK; ATP4A; FAN1; OPA1; PRPS1; PKM; STK36; TSSK3|
|nucleotide binding||MAP2K4A; TUBB5; FGFR1B; TOR2A; GKUP; ATAD1A; SETD1B; PPARGC1B; DNAJC17; EIF4A1B|
|protein binding||CDIPT; CUL2; ILK; BPTF; ING4; SUGT1; TMEM31; SNX12; TEX14; MIEN1|
|protein homodimerization activity||PLCB1; BLOC1S6; MAOB; UGT1A1; HMGCR; EIF2AK3; SLC30A8; Defa-rs7; CIB2; DNM1L|
hprt1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hprt1 here. Most of them are supplied by our site. Hope this information will be useful for your research of hprt1.
WDYHV1; PRTFDC1; SDCBP; ISCU; EIF1B; HUS1; EPB41; MCC