ICAM3
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Official Full Name
intercellular adhesion molecule 3 -
Overview
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. [provided by RefSeq, Jul 2008] -
Synonyms
ICAM3;intercellular adhesion molecule 3;CD50;CDW50;ICAM-R;ICAM-3;intercellular adhesion molecule-3
Recombinant Proteins
- Human
- Rhesus macaque
- E.coli
- HEK293
- Mammalian cells
- Mammalian Cell
- Wheat Germ
- HEK293T
- In Vitro Cell Free System
- E.coli expression system
- His
- Fc
- Non
- His&T7
- His&Fc
- C-His-hFc
- GST
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ICAM3 involved in several pathways and played different roles in them. We selected most pathways ICAM3 participated on our site, such as Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with ICAM3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell adhesion molecules (CAMs) | ITGB1B.2,CTLA4,CD34,CNTNAP1,NLGN3,PVRL2,CADM3,PECAM1,NRCAMA,CLDN9 |
Protein Function
ICAM3 has several biochemical functions, for example, integrin binding,protein binding,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ICAM3 itself. We selected most functions ICAM3 had, and list some proteins which have the same functions with ICAM3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | KLRC4-KLRK1,RPL27A,ZMYND19,TFPT,SF3A3,RHOXF2,TPM1,S100A14,DUT,EIF4A2 |
| integrin binding | DST,EMP2,SRC,PTPN2,ICAM4,CYR61,PXN,ADAMTS5,ADAM17,WISP1 |
| receptor binding | PSPN,INHA,FGF1A,TNFSF8,AKAP9,FGF8B,CX3CL1,HAO1,NPFF,Ifnl2 |
Interacting Protein
ICAM3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ICAM3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ICAM3.
ITGAL;ZBTB16;mhpD1
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References
- Park, KT; Burnett, S; et al. Development and characterization of a monoclonal antibody specific for bovine CD209. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 163:216-220(2015).
- Liu, P; Wang, X; et al. Low Copy Numbers of DC-SIGN in Cell Membrane Microdomains: Implications for Structure and Function. TRAFFIC 15:179-196(2014).
