| Description : |
Cell adhesion molecules (CAMs) are a family of closely related cell surface glycoproteins involved in cell-cell interactions during growth. These proteins are thought to play an important role in embryogenesis and development. ICAM-3, also designated CD50 and ICAM-R, is a type I membrane protein that is thought to regulate morphological changes during cell locomotion. ICAM-3 acts as a counter-receptor for the leukocyte Integrin αL/β2, and is known to activate T cells and polymorphonuclear leukocytes. ICAM-3 also binds to Moesin, via the cytoplasmic domain of ICAM-3. The expression of ICAM-3 is induced by RANTES, a chemoattractant known to activate T lymphocytes. ICAM-3 is also a major ligand for the leukocyte Integrin LFA-1 (CD11a/CD18). |
| Source : |
E. coli |
| Species : |
Human |
| Tag : |
C-His |
| Molecular Mass : |
~50 kDa |
| AA Sequence : |
QEFLLRVEPQNPVLSAGGSLFVNCS TDCPSSEKIALETSLSKELVASGMG WAAFNLSNVTGNSRILCSVYCNGSQ ITGSSNITVYRLPERVELAPLPPWQ PVGQNFTLRCQVEDGSPRTSLTVVL LRWEEELSRQPAVEEPAEVTATVLA SRDDHGAPFSCRTELDMQPQGLGLF VNTSAPRQLRTFVLPVTPPRLVAPR FLEVETSWPVDCTLDGLFPASEAQV YLALGDQMLNATVMNHGDTLTATAT ATARADQEGAREIVCNVTLGGERRE ARENLTVFSFLGPIVNLSEPTAHEG STVTVSCMAGARVQVTLDGVPAAAP GQPAQLQLNATESDDGRSFFCSATL EVDGEFLHRNSSVQLRVLYGPKIDR ATCPQHLKWKDKTRHVLQCQARGNP YPELRCLKEGSSREVPVGIPFFVNV THNGTYQCQASSSRGKYTLVVVMDI EAGSSH |
| Purity : |
Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
| Notes : |
For research use only, not for use in diagnostic procedure. |
| Storage : |
Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. |
| Concentration : |
≥0.5 mg/mL |
| Storage Buffer : |
PBS, 4M Urea, pH7.4 |
