ICAM4
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Official Full Name
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -
Overview
This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. -
Synonyms
ICAM4;intercellular adhesion molecule 4 (Landsteiner-Wiener blood group);intercellular adhesion molecule 4 (LW blood group) , intercellular adhesion molecule 4, Landsteiner Wiener blood group , Landsteiner Wiener blood group , LW;intercellular adhesion molecule 4;CD242;CD242 antigen;ICAM-4;ICAM4_HUMAN;Landsteiner Wiener blood group glycoprotein;Landsteiner-Wiener blood group glycoprotein;LW;LW blood group protein;Landsteiner-Wiener blood group antigen a;intercellular adhesion molecule 4 (LW blood group)
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Rat
- E.coli
- HEK293
- Human Cell
- Mammalian cells
- HEK293T
- His
- Non
- Fc
- hIgG4
- His&GST
- His&Fc
- His&T7
- His&Fc&Avi
- Flag
- Myc&DDK
- His&SUMO
Involved Pathway
ICAM4 involved in several pathways and played different roles in them. We selected most pathways ICAM4 participated on our site, such as Adaptive Immune System,Extracellular matrix organization,Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with ICAM4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Integrin cell surface interactions | LOC100514666,FBN1,BSG,COL13A1,COL16A1,COL9A1B,COMP,F11R.2,FN1B,JAM2B |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | SIGLEC6,SIGLEC12,CD300A,SIGLEC9,CD300LG,LILRB3,KLRF1,CLEC2B,LILRA3,KLRB1F |
| Immune System | DEFA5,GBP4,MYO1C,GBP6,EGR1,KIF2B,PAG1,ASB18,DTX3L,TRIM9 |
| Extracellular matrix organization | COL5A1,CTS7,TIMP2,PCOLCE,MMP13,BMP1B,MFAP2,LOX,COL11A1B,FBN2 |
| Adaptive Immune System | PDPK1A,MAP3K8,UBR1,KIF3A,SIGLEC9,ASB2,CREB1,TRIM41,RAPGEF3,FGFR1B |
Protein Function
ICAM4 has several biochemical functions, for example, integrin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ICAM4 itself. We selected most functions ICAM4 had, and list some proteins which have the same functions with ICAM4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CD46,INCENP,GATA4,STX10,ADARB1,PPM1B,FAM101A,KPNA1,ZNF180,CHD4 |
| integrin binding | CTGFB,ESM1,WISP3,SYK,LAMB2,ADAM22,CIB2,JAM3,THY1,GFAP |
Interacting Protein
ICAM4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ICAM4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ICAM4.
CREB3;IGHG1
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References
- Wang, KP; Zhao, LQ; et al. Differential co-expression analysis of rheumatoid arthritis with microarray data. MOLECULAR MEDICINE REPORTS 10:2421-2426(2014).
- Rosette, C; Roth, RB; et al. Role of ICAM1 in invasion of human breast cancer cells. CARCINOGENESIS 26:943-950(2005).
