IL17B
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Official Full Name
interleukin 17B
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Background
The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. -
Synonyms
IL17B; interleukin 17B; interleukin-17B; IL 17B; IL 20; MGC138900; MGC138901; neuronal interleukin 17 related factor; NIRF; ZCYTO7; interleukin 20; interleukin-20; cytokine Zcyto7; interleukin-17 beta; cytokine-like protein ZCYTO7; neuronal interleukin-17;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL17B Related Gene Family
- IL17B Related Research Area
IL17B involved in several pathways and played different roles in them. We selected most pathways IL17B participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL17B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | CXCL12;PRL2;BMP7A;IL22RA1;TNFRSF9A;CXCR7;TNFRSF1B;CXCL3;Ccl21c |
IL17B has several biochemical functions, for example, cytokine activity, cytokine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL17B itself. We selected most functions IL17B had, and list some proteins which have the same functions with IL17B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | LIF;BMP6;GDF10B;NDP;TGFB2;GDF15;CCL38.1;Ccl12;IL36RN |
| cytokine receptor binding | IL17A/F2;IL15;IL17A/F3;IFNA5;MIF;IFNPHI1;IFNA3;IL17C;IL17A/F1 |
IL17B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL17B here. Most of them are supplied by our site. Hope this information will be useful for your research of IL17B.
ENO2
- Q&As
- Reviews
Q&As (10)
Ask a questionCo-culture experiments and signaling pathway analysis reveal IL17B's interaction with other cytokines.
Techniques like surface plasmon resonance elucidate IL17B's binding to its receptor.
In vivo models combine IL17B overexpression or neutralization with tumor models to study its role.
Human tissue samples are analyzed using immunohistochemistry and cytokine profiling to understand IL17B's effects.
Flow cytometry and functional assays explore how IL17B affects immune cell activation and cytokine production.
Research uses animal models and biomarker analysis to study IL17B in neuroinflammatory diseases.
Genetic techniques like CRISPR/Cas9 knockout or siRNA knockdown validate IL17B's functional impact.
Transwell assays and impedance-based methods evaluate IL17B's impact on endothelial barrier integrity.
Western blotting and phosphorylation assays uncover IL17B's downstream signaling pathways.
Gene expression analysis involves qPCR or RNA sequencing to distinguish IL17B expression patterns.
Customer Reviews (3)
Write a reviewSuitable for signaling studies. -
High solubility -
Potent in B-cell assays. -
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