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Recombinant Rat Il17b protein, His-tagged

Cat.No. : Il17b-1821R
Product Overview : Recombinant Rat Il17b aa. (Arg23~Phe180 (Accession # G3V8K9)) fused with N-terminal His tag was produced in E. coli cells.
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  • Gene Information
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Description : Human homolog is a T cell-derived cytokine that may be involved in the proinflammatory response.
Source : E. coli
Species : Rat
Tag : His
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 19.4kDa
Protein length : Arg23~Phe180 (Accession # G3V8K9)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 9.5.
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : Il17b interleukin 17B [ Rattus norvegicus (Norway rat) ]
Official Symbol : Il17b
Synonyms : Il17b; interleukin 17B; interleukin-17B
Gene ID : 116472
mRNA Refseq : NM_053789.1
Protein Refseq : NP_446241.1
UniProt ID : G3V8K9

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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What strategies are employed to investigate the cross-talk between IL17B and other cytokines in inflammatory responses? 09/01/2022

Co-culture experiments and signaling pathway analysis reveal IL17B's interaction with other cytokines.

How does IL17B's structure affect its receptor binding affinity, and what experimental techniques reveal this? 07/16/2022

Techniques like surface plasmon resonance elucidate IL17B's binding to its receptor.

How is the impact of IL17B on cancer progression studied using in vivo models? 05/01/2022

In vivo models combine IL17B overexpression or neutralization with tumor models to study its role.

What experimental designs are used to understand the role of IL17B in tissue-specific inflammation in human samples? 08/16/2021

Human tissue samples are analyzed using immunohistochemistry and cytokine profiling to understand IL17B's effects.

Can you elaborate on the techniques used to determine IL17B's role in modulating immune cell behavior? 12/16/2020

Flow cytometry and functional assays explore how IL17B affects immune cell activation and cytokine production.

What are the approaches to analyzing IL17B's involvement in neuroinflammation and central nervous system disorders? 07/05/2019

Research uses animal models and biomarker analysis to study IL17B in neuroinflammatory diseases.

Can you explain the use of genetic knockout or knockdown techniques to validate IL17B's functional effects? 05/24/2019

Genetic techniques like CRISPR/Cas9 knockout or siRNA knockdown validate IL17B's functional impact.

Could you detail the experimental protocols to assess the effect of IL17B on endothelial barrier function? 07/06/2018

Transwell assays and impedance-based methods evaluate IL17B's impact on endothelial barrier integrity.

How do researchers identify the downstream signaling pathways activated by IL17B and its receptor? 11/01/2017

Western blotting and phosphorylation assays uncover IL17B's downstream signaling pathways.

What experimental methods differentiate IL17B from other IL17 family members during gene expression analysis? 04/12/2017

Gene expression analysis involves qPCR or RNA sequencing to distinguish IL17B expression patterns.

Customer Reviews (3)

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Reviews
05/14/2022

    Suitable for signaling studies.

    10/30/2020

      High solubility

      10/10/2017

        Potent in B-cell assays.

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